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reposted by
Trevor Graham
5 months ago
Using barcodes 📊 to track cancer 💊 resistance evolution: is it clonal selection or plasticity?
@fwhiting.bsky.social
knows! His new "Evolutionary Informed Resistance Assays" (EIRAs) framework infers resistance evolution dynamics from barcode diversity data.
www.nature.com/articles/s41...
@icr.ac.uk
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Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding - Nature Communications
Understanding the dynamics of how drug resistance originates in cancer remains crucial, but it is not possible to observe them directly. Here, the authors construct a mathematical framework to infer d...
https://www.nature.com/articles/s41467-025-59479-7
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