@yuhminchook.bsky.social
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Selinexor is an allosteric degrader. It stabilizes XPO1/CRM1 to expose a cryptic ASB8 E3 ligase site, triggering ubiquitination. Led by Casey Wing, Joyce Fung & Bert Kwanten.
#TargetedDegradation
#Allostery
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SINE compounds activate exportin 1 degradation through an allosteric mechanism - Nature Chemical Biology
Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). Wing, Fung and Kwanten et al. found that selinexor mediates XPO1 degradation through an allosteric molecule glue mec...
https://www.nature.com/articles/s41589-025-02058-0
29 days ago
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reposted by
Trends in Biochemical Sciences
3 months ago
📝 Available online - the Review "The nuclear export receptor CRM1/XPO1 and its diverse cargoes" from Ralph Kehlenbach and
@yuhminchook.bsky.social
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#CRM1
#Exportin1
#NuclearTransport
#NuclearPoreComplex
#RNAExport
Read it here:
authors.elsevier.com/sd/article/S...
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The review article on CRM1/XPO1 that Ralph Kehlenbach and I wrote (we made the figures too) is online at TIBS
@cp-trendsbiochem.bsky.social
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authors.elsevier.com/sd/article/S...
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ScienceDirect.com | Science, health and medical journals, full text articles and books.
https://authors.elsevier.com/sd/article/S0968-0004(25)00221-X
3 months ago
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