MICLAB - Medicinal Inorganic Chemistry Lab (@miclabatunipi.bsky.social)

New paper for MICLAB about oxaliplatin(IV) complexes functionalised with monohaloacetes ligands as multimodal prodrugs. Now published in @daltontrans.rsc.org doi.org/10.1039/D6DT... #platinumcomplexes #medicinalchemistry #prodrugs #chemistry #bioinorganic

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Engineering oxaliplatin(IV) prodrugs with monohaloacetates for redox-responsive and multimodal anticancer activity A series of novel oxaliplatin(iv) complexes bearing monohaloacetic acids (MAAs) were synthesised to address the limitations of platinum-based chemotherapy related to severe side effects and resistance phenomena. Both symmetrical [Pt(DACH)(ox)(MAA)2] and asymmetrical [Pt(DACH)(ox)(MAA)(OAc)] derivatives featuring mo https://doi.org/10.1039/D6DT00471G