It would be not a surprise if basic rules in cancer are understood.😆😋🧐 1. Most oncoproteins are embryonic neural/neural stemness proteins, including CK2. 2. Inhibition of oncoproteins suppresses tumorigenicity&boost immunogenicity. blog.google/technology/a...

LEADING EDGE study of Epithelial-mesenchymal transition in latest @cp-cell.bsky.social @nature.com @natureportfolio.nature.com @scinews.bsky.social cell.com/cell/fulltex... 'Lack of basic rationale in epithelial-mesenchymal transition ..' cellandbioscience.biomedcentral.com/articles/10....

In the latest issue of CELL! Researchers reported the LEADING EDGE study of Epithelial-mesenchymal transition. @cp-cell.bsky.social @nature.com @natureportfolio.nature.com @scinews.bsky.social www.cell.com/cell/fulltex...

Neuroendocrine tumors surprisingly do not originate from neuroendocrine cells, and there exists muscle cancer with non-muscle origin, and osteosarcomas with extraskeletal origin. Hard to understand? '..Neural Stemness as the Core Property of Cancer Cell' preprints.org/manuscript/2...

Cancer is confusing: Neuroendocrine tumors surprisingly do not originate from neuroendocrine cells, and (some) muscle cancer originate from non-muscle cells. Hard to understand? '..Understanding Neural Stemness as the Core Property of Cancer Cell' preprints.org/manuscript/2...

Cancer (tumorigenic) cells are characteristic of neural stem/embryonic neural cells, are capable of neuronal-like differentiation&making connections with host neural cells. @cp-cancercell.bsky.social '..Understanding Neural Stemness as the Core Property of Cancer Cell' preprints.org/manuscript/2...

Cancer (tumorigenic) cells are characteristic of neural stem/embryonic neural cells, are capable of neuronal-like differentiation&making connections with host neural cells. @cp-cancercell.bsky.social '..Understanding Neural Stemness as the Core Property of Cancer Cell' preprints.org/manuscript/2...

Simply put, cancer cell can be induced to neuronal (&non-neural) differentiation, thereby suppressing cancer cell tumorigenicity. @nature.com ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2...

@natureportfolio.nature.com What the hell the poorly defined EMT stuff can help to understand cancer? ''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts" cellandbioscience.biomedcentral.com/articles/10.... www.nature.com/articles/s41...

'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts" cellandbioscience.biomedcentral.com/articles/10.... "Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell" www.preprints.org/manuscript/2...

What the hell the extremely poorly defined EMT stuff can help to understand cancer? @cp-devcell.bsky.social ''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts" cellandbioscience.biomedcentral.com/articles/10.... www.cell.com/developmenta...

What the hell the poorly defined EMT stuff can help to understand cancer? ''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts" cellandbioscience.biomedcentral.com/articles/10....

What the hell the extremely poorly defined EMT stuff can help to understand cancer? @drweb2.bsky.social ''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts" cellandbioscience.biomedcentral.com/articles/10....

What the hell the extremely poorly defined EMT stuff can help to understand cancer? @bigearthdata.bsky.social ''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts" cellandbioscience.biomedcentral.com/articles/10....

What the hell can the poorly defined EMT stuff be a little bit helpful for understanding cancer? @nature.com ''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts" cellandbioscience.biomedcentral.com/articles/10....

Cancer (tumorigenic) cells are characteristic of neural stem/embryonic neural cells, and are capable of neuronal-like differentiation, making connections with host neuronal cells. ‘.. Understanding Neural Stemness as the Core Property of Cancer Cell’ @nature.com preprints.org/manuscript/2...

What the hell the extremely poorly defined EMT stuff can be a little bit helpful for understanding fibrosis/cancer? ''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts" cellandbioscience.biomedcentral.com/articles/10.... @jci-insight.bsky.social

@nature.com It seems that the relationship: Cancer cell≈neural cell⇒phenotypic plasticity revealed in the original paper, didn't draw any attention.🧐😟 Plus, as generalized before, most cancer promoting genes are enriched embryonic neural cells, including hmgb2. www.preprints.org/manuscript/2...

'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts’ cellandbioscience.biomedcentral.com/articles/10.... ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2...

What the hell the poorly defined epithelial-mesenchymal transition can be a little bit helpful for understanding cancer, and how the poorly defined stuff can be a target of cancer therapy? www.embopress.org/doi/full/10....

'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell' preprints.org/manuscript/2... @nature.com

It becomes clearer and clearer: Cancer cell≈neural cell⇒phenotypic plasticity www.nature.com/articles/s41... @nature.com

'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell' preprints.org/manuscript/2... @nature.com @oncodaily.bsky.social

It becomes clearer and clearer. Cancer cell≈neural cell⇒phenotypic plasticity nature.com/articles/s41... @nature.com @oncodaily.bsky.social

5K yrs since the 1st recording of cancer in history. How much has cancer cell & cancer been understood? Still need to wait for another 5K yrs? 'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell' www.preprints.org/manuscript/2...

Activation of embryonic neural/neural stemness genes and decrease of genes confering immunogenicity is the general rule of tumorigenesis. The general relationship between tumorigenicity and immunogenicity of cancer cells👇 biorxiv.org/content/10.1... @natcomms.nature.com

If neural stemness is known as the core property of cancer cell, perhaps cancer is much easier to understand. 'Patient and zebrafish mucosal melanomas show increased migratory neural crest and decreased antigen presentation gene expression' www.nature.com/articles/s41... @natcomms.nature.com

Cancer has been known for ~5k yrs since the earliest recording in history, & countless efforts invested for understanding it, from the scale of evo-ecosystem to the scale of single nucleotides. But how much has been understood about cancer cell&cancer? preprints.org/manuscript/2...

Neural stemness unifies embryogenesis and tumorigenesis: acquirement of neural stemness in non-neural cells is required for both embryonic body axis formation and tumorigenesis. Characteristics of a tumor as a conjoined twin-like structure.

Neural stemness as the core property of cancer cell, and its contribution to 'cancer ecosystem'

Unicellular origin of neural stemness/pluripotency, and the 'neural default state'

Outline

Cancer been known for ~5000y &modern biomedical research has become refined to the scale of atoms. Now is the time to understand cancer. PREPRINT alert: 'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell' www.preprints.org/manuscript/2...

5y ago, The EMT International Association (TEMTIA) made a consensus statement on EMT. Now is time to make update to clarify critical issues regarding the rationality of EMT, either to avoid unnecessary waste of huge efforts or to enable healthy progress of research if 'EMT' truly exists.

Maybe clinicians should be told: What are the so-called E/M states? EMT specific markers/factors? direct evidence of 'EMT'? basic rationale in 'EMT'? and how can a poorly defined 'EMT' be helpful for understanding cancer? cellandbioscience.biomedcentral.com/articles/10....

Why is cancer so hard to understand? Maybe something already wrong in the root.

Cancer is a disease of cellular property change, not just change in gene/protein symbols. Making correct association between the symbols with cellular state/property is critical for understanding cancer. Wrong associations, eg, the so-called EMT factors, generate only confusion.

What the hell is the physiological relevance between the poorly defined 'EMT/EMP' and cancer? The relevance👇

EMT is widely used to explain cancer cell migration..., but nobody knows what are E/M states and what is 'EMT'. Neural stem/progenitor cells are well known for their single cell migration&cancer cells are characteristic of neural stemness, but people try to avoid mentioning it.

Why the epithelial-mesenchymal transition/plasticity stuff, which has been studied for >50 years w/ >50K papers published, yet nothing is known about its basics, is so stubbornly considered to be helpful for understanding cancer? Understanding cancer is a life-saving business.

This paper 👉https://nature.com/articles/s41586-025-09111-x & previous others showed NO EPITHELIAL-MESENCHYMAL TRANSITION AT ALL. ''Lack of basic rationale in epithelial-mesenchymal transition and its related concepts" cellandbioscience.biomedcentral.com/articles/10....

Maybe the clinicians should know: What are the so-called epithelial/mesenchymal states? EMT specific markers/factors? direct evidence of 'EMT'? basic rationale in 'EMT'? and how can a poorly defined 'EMT' be helpful for understanding cancer?

But Ecad loss leads to upregulation of GRPR/YAP1, both are embryonic neural, supporting 'tumorigenesis represents progressive loss of original cell identity and gain of neural stemness'. It's well known that neural stem/prog. cells undergo single-cell migration. @nature.com

@nature.com No epithelial-mesenchymal transition! In the context of 'epithelial-mesenchymal trasnition', loss of epithelial state, eg, by loss of Ecad, will inevitably cause transition to mesenchymal state, thereby promoting metastasis. This paper (&also others) shows no EMT at all.

Can any physiological relevance be found between the poorly defined 'EMT' and cancer? The physiological relevance👇 @nature.com

'EMT' and cancer: It is not the indefinable mesenchymal but the neural stuff that really matters. @nature.com

Why is cancer so hard to understand? Sth. wrong already in the root. After>50y EMT study w/ >50K papers published, what is clear about EMT? E/M cellular states? EMT-specific markers? Rationale of EMT? Clear evidence? Nothing at all. @nature.com cellandbioscience.biomedcentral.com/articles/10....

Why is the extremely poorly defined epithelial-mesenchymal transition so seriously considered helpful for understanding cancer? '...increasing TGFβ activity and promoting epithelial-to-mesenchymal transition (EMT)' nature.com/articles/s41... @Nature.com

Normal animal/human contains heterogeneous cell types, but not disordered; A conjoined twin contains heterog. cells, but not disordered; A conjoined twin is driven by ectopic neural induction in an embryo; Cancer is driven by neural induction-like process in postnatal animal/human.

Of course not disordered. Understanding cancer as a systemic disease by understanding the biggest thing in embryogenesis: embryonic (neural) induction. www.nature.com/articles/s41...