Understanding the negative correlation between cancer and neurodegeneration by understanding what is the core property of cancer cell. 'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell' preprints.org/manuscript/2... @nature.com

🤔🤫🫣

What does the 'high-plasticity cell state' actually mean? www.nature.com/articles/s41...

‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ www.preprints.org/manuscript/2...

Recent studies showed GOF mutation in MSI2 @science.org &increased SOX4 activity @cellpress.bsky.social are cancer drivers If notice MSI2&SOX4 are embryonic neural factors instead of two lifeless symbols, cancer might be better understood www.science.org/doi/10.1126/... www.cell.com/cell/fulltex...

What does 'a high-plasticity cell state' mean? @nature.com

The rule: ∵Tumorigenesis is a process of loss of original cell identity&gain of neural stemness, the general stemness determining tumorigenity&pluripotency. ∴tissue stem/progenitor cells are easier to become cancer cells because they are closer to neural stemness www.science.org/doi/10.1126/...

'Increased developmental activity (Sox4), decreased identity (HNF4A)' This is a latest confirmation for 'tumorigenesis represents the process of loss of original cell identity&gain of neural stemness' because Sox4 is embryonic neural and Hnf4a is hepatic.

'Increased developmental activity (Sox4), decreased identity (HNF4A)' This is a latest confirmation for 'tumorigenesis represents the process of loss of original cell identity&gain of neural stemness' because Sox4 is embryonic neural and Hnf4a is hepatic. @cp-cell.bsky.social

Neural stuff is the most fundamental stuff in animal world. It determines nearly everything in animals/humans, including embryogenesis and cancer. @science.org

Growth factors secreted by sensory nerves promote fracture healing. www.science.org/doi/10.1126/...

Most cancer promoting genes are embryonic neural genes, incl. KRAS&SMARCA5. They confer cancer cell with neural stemness, which determines pluripotency&tumorigenicity. Loss of SMARCA5 inhibits tumorigenicity&pluripotency, leading to differentiation (&regeneration)

Those who believe that EMT can help understand cancer&other things should first figure out what the hell is the basis on which EMT is established as a concept/rule @natcancer.nature.com @mskcancercenter.bsky.social nature.com/articles/s43... nature.com/articles/s43... @cedric-blanpain.bsky.social

But how much has cancer cell been actually understood? @cellpress.bsky.social

'..focused on the cancer cell itself ..enabled new generations of ..drugs that have benefited some patients with certain forms of cancer. Frustratingly, few of these new therapeutic strategies are broadly beneficial across..cancers' @cellpress.bsky.social www.cell.com/cell/fulltex...

Pro-tumorigenic regulatory networks are part of reg. networks of neural stemness (or embryonic neural reg. nets). ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2...

ASCL1, NEUROD1...appear as different symbols. If considering these genes are all embryonic neural genes, do they still indicate cancer subtypes? Making appropriate association between gene symbols and cellular property is critical for understanding cancer. onlinelibrary.wiley.com/doi/10.1111/...

Most cancer promoting genes are embryonic neural genes, incl. MSI2. They confer cancer cell with neural stemness that unifies cancer cell phenotypic traits. ‘.Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2... @mskcancercenter.bsky.social

The rule: GOF mutations in neural stemness genes or/and LOF mutations in differentiation/tissue specific genes increase cancer risk, LOF mutations in neural stemness genes or/and GOF mutations in differentiation/tissue specific genes decrease cancer risk. @mskcancercenter.bsky.social

Cross-pollination without Developmental biology🫣 Dev. biol. explains how the most complex systems are generated but very funny it is not considered in the book, but the undefinable epithelial-mesenchymal transition stuff was seriously discussed in 4 chapters of the book to explain cancer. WOW.🤔

WOW. A NEW CANCER BOOK Cancer Systems Biology is..to encourage cross-pollination of ..multiple disciplines..systems/mathematical biologists, biophysicists, clinicians..in decoding a systems-level emergent view of cancer...EMT. but NO DEVELOPMENTAL BIOLOGY academic.oup.com/book/61412

tSCs mean tissue stemness, ESC stemness, other stemness, or nothing comparable? Any ideas? 'SOX2High tSCs...' is a clear indication that cancer stemness is neural stemness. SOX2 is an obvious marker connecting cancer stemness, ESC&neural stemness, &pluripotency. @cp-cancercell.bsky.social

'inhibition of MSI2..for blood cancer prevention' Cancer promoting pathways belong to the same regulatory network, ie, the reg net of neural stemness. Any big difference between targeting MSI2 or other factors in the same net? Cancer is a problem of cell property change, not merely mol. symbols.

As I generalized before, most cancer promoting genes are embryonic neural genes, incl. MSI2, which confer cancer cell with neural stemness that unifies cancer cell phenotypic traits. ‘.by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2...

Cancer is the manifestation of the power of the rules dictated by evolution. ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2...

'New theory needed' Reminds of research about pluripotent feature of cancer cells during 1960-90. Pluripotency suggests a key feature in understanding cancer complexity and developing cancer therapy. Sometimes, theory is perhaps already there. But it won't wave at you and say, "Hi, I'm here"😂

Commonality between different cancers: Cancer (tumorigenic) cells≈Neural (stem/progenitor) cells. Cancer cell regulatory networks ≈ Reg. networks of neural stemness. Cancer cells are capable of multilineage differentiation incl. neuronal differentiation.

‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2...

Therefore, how much have cancer cell and cancer...been properly understood? @science.org www.science.org/content/arti...

Neural genes are the oldest genes in the animal world. They are truly qualified to dominate essentially almost everything that happens in the animal kingdom, including cancer. @nature.com

Understanding cancer cell and cancer and cancer complexity by understanding the basic relationship between the basic cellular properties and the basic rules in the animal world. ‘..Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2... @nature.com

Cancer (tumorigenic) cell ≈ Neural (stem/progenitor) cell. It is not just tumor-nerve interaction. 'A growing body of research suggests tumours rely on proteins and genes that are unique to the nervous system to persist in the body' @nature.com www.nature.com/articles/d41...

Understanding the basic property of cancer cell is essential for developing cancer therapeutic strategies. ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ www.preprints.org/manuscript/2...

The core property of cancer cell is neural stemness, which unifies phenotypic traits of cancer cell, including metabolism, metastasis,.. Like most cancer promoting genes, MALAT1 is also an embryonic neural gene, a component of reg. networks of neural stemness. www.preprints.org/manuscript/2...

Understanding cancer cell&cancer&cancer complexity by understanding the basic relationship between the basic cellular properties and the basic rules in the animal world. Neural is fundamental👇 ‘..Understanding Neural Stemness as the Core Property of Cancer Cell’ www.preprints.org/manuscript/2...

If you think this is helpful for understanding cancer, first of all, please make clear what the hell it is and how it can be helpful. No kidding👇 "mesenchymal-like transcriptional identity"😘🤥

Embryonic neural regulatory networks = pluripotency reg. networks.

'A ligand/receptor trafficking clock governs self-renewal and abscission dynamics in pluripotent stem cells' www.biorxiv.org/content/10.6...

The rule:

As I generalized before, most cancer promoting genes are embryonic neural, and most suppressor genes are non-neural. 👉Therefore, the core property of cancer cell being neural stemness implies that most embryonic non-neural genes suppress cancer, e.g., RIPK3. www.science.org/doi/10.1126/...

Stressing out and trying to be the best as a kid usually makes you worse as an adult.

Major oncogenes, incl. KRAS, are embryonic neural, conferring cancer cell with neural stemness, which determines pluripotency/plasticity&tumorigenicity of cancer cell; pluripotency&tumorigenicity can be suppressed by inhibition of neural stemness via differentiation @aacrjournals.bsky.social

'a central role for oncogenic KRAS in governing cellular plasticity in mCRC. ...underscore cell plasticity as a therapeutic opportunity' @aacrjournals.bsky.social aacrjournals.org/cancerdiscov...

TP53: the most widely investigated gene in cancer the 'most important single tumor suppressor' 'the most important' does not work in treating cancer but some 'less important factors' work. 🙄🤠👇 TP53 ⊣ DNAmuts ≠ cancer ∴TP53 does not inhibit cancer www.nature.com/articles/s43...

Initiation and progression of different cancers follow a similar rule: Tumorigenesis as a process of gradual loss of original cell identity and gain of properties of neural precursor/progenitor cells link.springer.com/article/10.1...

Different types of cancer cells share similar cellular property, neural stemness. Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells www.jbc.org/article/S002...

It is not just proliferation, not just metabolism, not just immunoevasion, ...but a basic cellular property, neural stemness, that is critical for understanding the core of cancer cell. Neural stemness contributes to cell tumorigenicity link.springer.com/article/10.1...

The basic relationship between the basic cellular properties: critical for understadning cancer.... Neural stemness unifies cell tumorigenicity and pluripotent differentiation potential sciencedirect.com/science/arti...

The basic relationship between the basic cellular proeprties: critical for understanding cancer,... Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential link.springer.com/article/10.1...