No matter whatever the niche is, cancer initiation and progression needs activation/upreg of genes enriched in embryonic neural cells, eg EGFR/SOX9, such that cancer cells acquire neural stemness &phenotypic traits. @nature.com

'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts’ link.springer.com/article/10.1... @natrevcancer.nature.com

'We, the editors, highlight the most exciting topics in cancer research' Those who believe EMT can help understand cancer or other things should first figure out what the hell is the so-called EMT&how it can be helpful &so exciting.😅 www.nature.com/articles/s41... @natrevcancer.nature.com

Understanding cancer cell &cancer complexity/therapy &even the inverse correlation between cancer and Alzheimer's as a whole by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. preprints.org/manuscript/2... @cp-trendscancer.bsky.social

What does cancer cell look like and why it has the power to 'hijack neural metabolism' @cp-trendscancer.bsky.social

Cancer cell 'hijacks' neural metabolism or cancer cell is intrinsically neural?🤔 Targeting neuro–tumor metabolic circuits to treat cancer or direct inhibition of neural feature of cancer cell? Big difference. cell.com/trends/cance... @cp-trendscancer.bsky.social

Intersection of cancer hallmarks and neuroscience in tumor environment: NEURAL PROPERTY OF CANCER CELL IS THE KEY. ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2...

NEURAL PROPERTY OF CANCER CELL IS THE KEY. Understanding cancer cell/complexity/therapy &even intersection of cancer hallmarks and neuroscience... as a whole by understanding neural stemness as the core property of cancer cell &rules behind. @cp-cancercell.bsky.social www.cell.com/cancer-cell/...

Host nervous systems promote cancer. For cancer therapy, it is better to block the host nervous system on cancer or it is better to block the neural property of cancer cell itself? So, blocking host nervous systems or neural property of cancer cells? That's the question. @cellpress.bsky.social

Neural property of cancer cell👇

Influence of host nervous system on cancer and cancer-host nerve connection are of course important to investigate. But how about the neural property of cancer cells? @cellpress.bsky.social www.cell.com/cell/fulltex...

Host nervous systems promote cancer. For cancer therapy, it is better to block the influence of the host nervous system on cancer or it is better to block the neural property of cancer cell itself?

Understanding cancer cell &cancer-neuron connection &even the inverse correlation between cancer and Alzheimer's &... as a whole by understanding neural property of cancer cell &the rules dictated by neural stemness preprints.org/manuscript/2... @cellpress.bsky.social www.cell.com/cell/fulltex...

Understanding cancer cell &cancer complexity/therapy &even the inverse correlation between cancer and Alzheimer's &... as a whole by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. preprints.org/manuscript/2... @cp-trendscancer.bsky.social

"Neural hijacking in cancer metabolism" sciencedirect.com/science/arti... @cp-trendscancer.bsky.social

Evolutionary and developmental basis for neural stemness as the general stemness, the cellular property/state that determines pluripotency and tumorigenicity. preprints.org/manuscript/2...

Q: True or not? A: Prefer not to say.

😅

Understanding cancer cell &cancer complexity &cancer therapy &even the inverse correlation between cancer and Alzheimer's disease &even chemobrain.... as a whole by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. preprints.org/manuscript/2...

Authors of the review are neural crest (NC) researchers. They are very clear that snai1/2,..are NEURAL CREST but not 'mesenchymal specifiers'. They still think NC migration is the consequence of EMT because of Snai1/2..are 'EMT markers' Awesome. @natrevmcb.nature.com www.nature.com/articles/s41...

cancers result from loss of original cell identity&acquirement of neural stemness. start points of cancers are different, but the destination is the same: neural stemness. the routes from different start points to a same destination must be different @nature.com www.nature.com/articles/s41...

Understanding cancer cell &cancer complexity &cancer therapy &even the inverse correlation between cancer and Alzheimer's disease............ by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. preprints.org/manuscript/2...

😅

Those who believe epithelial-mesenchymal transition (EMT) can help understand cancer or other things should first figure out what the hell is the so-called EMT&how it can be a little bit helpful. 'Lack of basic rationale in EMT and its related concepts' link.springer.com/article/10.1...

Cancer research is life-saving🫡 "epithelial-mesenchymal transition" saves lives.🫡 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts’ link.springer.com/article/10.1... @nature.com

"...epithelial-mesenchymal transition." Those who believe EMT can help understand cancer or other things should first figure out what the hell is the so-called EMT&how it can be helpful. 'Lack of basic rationale in EMT...’ link.springer.com/article/10.1... www.nature.com/articles/s41...

As generalized before, most cancer promoting genes are embryonic neural/neural stemness genes, incl EED. They confer cancer cell with neural stemness, which determines pluripotency and tumorigenicity.

Humans understand the universe by understanding gravity, not by observing a crack on the surface of a moon of Saturn.

Understanding cancer as a developmental effect &even inverse correlation between cancer and Alzheimer's disease ...... by Understanding Neural Stemness as the Core Property of Cancer Cell &the rules in developmental biology dictated by neural stemness👇 preprints.org/manuscript/2...

But how cancer can be interpreted as a developmental effect? The answer👇

Do you know?👇 Cancer is a problem of developmental biology (1978)

To be simple, the basic relationship:

But if the smart artificial intelligence knew the 'neural default state' of embryonic pluripotent cells, it would have given the perfect answer.😜

5K years since the earliest documentation of cancer in human, and ~6 million cancer papers published so far. But how much the basic feature of cancer cell has been understood so far? Artificial intelligence is smart, it gives a good answer.😂🤔🤠🙄

I found the following, but they are considered as RUBBISH, and rubbish of course deserves nothing, particularly research funding. So, lab to be closed, research must be stopped.

I found the following, but they are considered as RUBBISH, and rubbish of course deserves nothing, particularly research funding. So, lab to be closed, research must be stopped.

Exactly. Fundamental biology unveils the top secret of cancer. Understanding cancer &even the inverse correlation between cancer and Alzheimer's disease...... by understanding neural stemness as the core property of cancer cell&rules behind preprints.org/manuscript/2... @crukcamcentre.bsky.social

Understanding cancer cell &cancer complexity &cancer therapy &even inverse correlation between cancer and Alzheimer's disease... as a whole by Understanding Neural Stemness as the Core Property of Cancer Cell &the rules dictated by neural stemness www.preprints.org/manuscript/2...

Interpreting cancer cell&cancer complexity&cancer therapy&even inverse correlation between cancer and Alzheimer's disease as a whole ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2... @cp-cell.bsky.social

Interesting to learn that tumors are outlaw organs. If so, what outlaw organ is liver cancer? It's outlaw liver or outlaw breast or both? What outlaw organ are teratocarcinomas? or what outlaw organ are extraskeletal osteocarcinomas? @cp-cell.bsky.social

Those who believe EMT/P can help understand cancer or other things should first figure out what the hell is the so-called EMT/P&how it can help. 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' @cp-cell.bsky.social link.springer.com/article/10.1...

‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2... @cellpress.bsky.social