Those who believe that EMT is helpful for understanding cancer and other things should first figure out what the hell is the so-called EMT&how it can be helpful 'Lack of basic rationale in epithelial-mesenchymal transition&related concepts' link.springer.com/article/10.1... @bmc.springernature.com

The EMT community still cannot face EMT's essential flaws directly They simply remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the so-called EMT factors, eg, ZEB1 link.springer.com/article/10.1...

'Blood-brain barrier' in cancer? Because the core property of cancer cell is neural stemness, and cancer also has a 'brain' @cp-cell.bsky.social

How possible to understand cancer cell plasticity with the so-called EMT, a 'concept' that nobody know what it is?

Those who believe that EMT is helpful for understanding cancer and other things should first figure out what the hell is the so-called EMT&how it can be helpful. 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' link.springer.com/article/10.1...

Recently EMT study resurges. The EMT community still cannot face EMT's fatal flaws directly They remain a stance of ignoring&silent about the related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about a few EMT factors www.nature.com/articles/s43...

Neurodevelopmental genes control essentially everything in animal kingdom If no neurodevelopmental genes, then no animals, then no cancer, no cancer research, no journals, no papers, no...... @nature.com But what the hell is the so-called epithelial mesenchymal transition?

'Netrin1, ..regulator of tumour epithelial-to-mesenchymal transition' Relating primarily a neurodevelopmental factor to the so-called EMT, something that no one knows what it is yet, is indeed absurd enough. @nature.com

Cancer is not a sum of mol. symbols, nor incoherent conjectures/hypotheses. Cancer has always hinted at the existence of basic rules through its complexity and the suffering it causes.

Do you know this basic relationship? From this it can be deduced immediately that inhibition of typical oncogenes suppresses tumorigenesis and also disrupts embryogenesis, leading to a phenotype of (even very early, depends) embryonic lethality😆 In fact, it is the case😆

Reminds of another case of cancer research:

Cancer is a systemic disease. Understanding a systemic disease needs the understanding of systemic rules. Or cancer is the manifestation of the power of the general rules dictating the animal kingdom, which are predetermined by evolution.

Evolutionary mechanism of tumorigenesis👇

Evolutionary mechanism of tumorigenesis👇 evolutionary and developmental basis for neural stemness as the general stemness, which determines pluripotency and tumorigenicity

A real pity This review in @nature.com emphasizes tumorigenesis reflects an effect of evolution and made conjectures/hypothesis about role of evolution in cancer Unfortunately, the evolutionary mechanism of tumorigenesis revealed previously wasn't mentioned at all www.nature.com/articles/s41...

Cancer is a systemic disease. Understanding a systemic disease needs the understanding of systemic rules. Or cancer is the manifestation of the power of the general rules dictating the animal kingdom, which is predetermined by evolution @nature.com preprints.org/manuscript/2...

Evolutionary mechanism of tumorigenesis👇 evolutionary and developmental basis for neural stemness as the general stemness, which determines pluripotency and tumorigenicity @nature.com

The evolutionary mechanism of tumorigenesis👇 Unicellular origin of neural cell state

The evolutionary mechanism of tumorigenesis👇 Evolutionary advantage of neural genes and neural cell state (unicellular origin) determine tumorigenicity and pluripotency. @nature.com

To be simple: Cancer hallmarks: 1. Cancer (tumorigenic) cells ≈ Neural stem/progenitor cells (neural stemness as the core property of cancer cells) 2. Tumors ≈ Conjoined twin-like structures (formed during postnatal stage) (cancer complexity)

Since the 1st set of "cancer hallmarks" in 2000, there have been hallmarks next generation, new dimensions, then, now&future, of cancer stemness, of cancer metabolism, of cancer stem cells,... Explain cancer complexity with cancer hallmark complexity? But there is another way👇

Basic logic: Metabolism is not an independent feature. Metabolic modes of different cells are different. If you wish to emphasize the critical importance of metabolism in cancer cell, you should make a clear definition and clarification. Otherwise, what does it help? @scinews.bsky.social

Funny that metabolism regarded as the prime factor defining cancer cell plasticity&... When talking about cancer cell metabolism, it's about the metabolism of muscle cells, of skin cells, of.... You can never understand cancer with unclarified stuffs. Cancer cell 'plasticity'👇 @scinews.bsky.social

This figure shows the big progress in myeloma treatment based on cancer biology research. But if the many problematic issues in cancer biology research were addressed frankly, this trend might have come sooner and might not be limited to myeloma.

Neural property of cancer cell is the key. Cancer is a systemic disease. Understanding a systemic disease needs the understanding of systemic rules. Or cancer is the manifestation of the power of the general rules dictating the animal kingdom.

Understanding cancer cell property incl. metastasis &cancer complexity &even the inverse correlation between cancer andAlzheimer's... as a whole by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. preprints.org/manuscript/2...

'..ETV1/4/5 as master regulators of the MTM program' I generalized that cancer promoting genes incl. metastasis are embryonic neural genes&the core property of cancer cell is neural stemnesss. Is the so-called MTM something different? No. because ETV1/4/5 are embryonic neural.

BREAKING: new concept explaining cancer metastasis emerges, 'metastatic trabecular morphogenesis (MTM)' Cancer cannot be explained by devising new but unclarified'concept'. Confusion caused by the so-called 'EMT concept' is still there. @cellpress.bsky.social www.cell.com/cell/fulltex...

'..two distinct progenitor-like cell states—neuroepithelial-like and embryonic-like—that are reminiscent of early human brain development..' '..subset of neuroepithelial-like cells that are both proliferative and highly migratory..' nature.com/articles/s41... @nature.com

"...but their link remains obscure" Link obscure or obscured? @bigearthdata.ai 👇

"...but their link remains obscure" Link obscure or obscured? @cryoempapers.bsky.social 👇

"...but their link remains obscure" Link obscure or obscured? @nature.com

Interesting or not?

🤣😂

No matter whatever the niche is, cancer initiation and progression needs activation/upreg of genes enriched in embryonic neural cells, eg EGFR/SOX9, such that cancer cells acquire neural stemness &phenotypic traits. @nature.com

'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts’ link.springer.com/article/10.1... @natrevcancer.nature.com

'We, the editors, highlight the most exciting topics in cancer research' Those who believe EMT can help understand cancer or other things should first figure out what the hell is the so-called EMT&how it can be helpful &so exciting.😅 www.nature.com/articles/s41... @natrevcancer.nature.com

Understanding cancer cell &cancer complexity/therapy &even the inverse correlation between cancer and Alzheimer's as a whole by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. preprints.org/manuscript/2... @cp-trendscancer.bsky.social

What does cancer cell look like and why it has the power to 'hijack neural metabolism' @cp-trendscancer.bsky.social

Cancer cell 'hijacks' neural metabolism or cancer cell is intrinsically neural?🤔 Targeting neuro–tumor metabolic circuits to treat cancer or direct inhibition of neural feature of cancer cell? Big difference. cell.com/trends/cance... @cp-trendscancer.bsky.social

Intersection of cancer hallmarks and neuroscience in tumor environment: NEURAL PROPERTY OF CANCER CELL IS THE KEY. ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2...

NEURAL PROPERTY OF CANCER CELL IS THE KEY. Understanding cancer cell/complexity/therapy &even intersection of cancer hallmarks and neuroscience... as a whole by understanding neural stemness as the core property of cancer cell &rules behind. @cp-cancercell.bsky.social www.cell.com/cancer-cell/...

Host nervous systems promote cancer. For cancer therapy, it is better to block the host nervous system on cancer or it is better to block the neural property of cancer cell itself? So, blocking host nervous systems or neural property of cancer cells? That's the question. @cellpress.bsky.social

Neural property of cancer cell👇

Influence of host nervous system on cancer and cancer-host nerve connection are of course important to investigate. But how about the neural property of cancer cells? @cellpress.bsky.social www.cell.com/cell/fulltex...

Host nervous systems promote cancer. For cancer therapy, it is better to block the influence of the host nervous system on cancer or it is better to block the neural property of cancer cell itself?