Paweł Pasikowski
@vitrioff.bsky.social
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Pro: Mass Spec / Proteomics / TPD Priv: S-F / Food-Wine-Beer / Boardgames / Absurd
I am not very good at advertising my work, but this one feels worth it:
link.springer.com/article/10.1...
So, there is this notorious neuroblastoma that gives really low chances of patients survival. And it turns out, that you can kill it with MGs (Molecular Glues NOT Machine Guns). TPD FTW! 1/2
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GSPT1-specific protein degradation is effective in preclinical models of chemoresistant MYCN-amplified neuroblastoma - Journal of Experimental & Clinical Cancer Research
Journal of Experimental & Clinical Cancer Research - High-risk neuroblastoma (HR-NB) is associated with therapy-resistant relapse, and novel therapeutic strategies are needed. GSPT1 is a GTPase...
https://link.springer.com/article/10.1186/s13046-026-03647-0
about 1 month ago
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Iva Tolić
2 months ago
PhD position in my lab!
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This is how one should use "AI". Not to give universal answers, just to facilitate specific tasks, like image analysis. And yes, it works better (still) when supervised.
add a skeleton here at some point
2 months ago
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Great read, 100% recommend
add a skeleton here at some point
5 months ago
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There are moments when I am ashamed to be a human... and me, for not doing enough to prevent what seems inevitable...
doi.org/10.1093/bios...
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The 2025 state of the climate report: a planet on the brink
We are hurtling toward climate chaos. The planet's vital signs are flashing red. The consequences of human-driven alterations of the climate are no longer
https://doi.org/10.1093/biosci/biaf149
5 months ago
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Cory Booker
6 months ago
This is a beautiful truth.
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Mariana Schuster
6 months ago
Looking for a friend 🙃 Does anyone have a reliable protocol for plasma membrane isolation/enrichment from N. benthamiana leaves, ideally for downstream proteomics. Got one that works? Please share or repost! 🌱🧬
#PlantProteomics
#Protocols
#NicotianaBenthamiana
#MembranePrep
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Björn Meyer
7 months ago
Twitter is dead.....scientifically speaking.
www.southernfriedscience.com/twitter-suck...
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“Twitter sucks now and all the cool kids are moving to Bluesky:” Our new survey shows that scientists no longer find Twitter professionally useful or pleasant
My colleague Dr. Julia Wester and I have a new paper out in the journal Integrative and Comparative Biology reporting on the results of a survey distributed to over 800 scientists, science educator…
https://www.southernfriedscience.com/twitter-sucks-now-and-all-the-cool-kids-are-moving-to-bluesky-our-new-survey-shows-that-scientists-no-longer-find-twitter-professionally-useful-or-pleasant/
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Nikolai Slavov
8 months ago
Science needs more public discussions focussed on constructive criticism. Such discussions are hard. Much harder than superficial praise that is popular on social media. Yet, scrutiny & rigor are more important for science than superficial praise.
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Zach Weinersmith
8 months ago
Max Born, writing in 1945
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Jack Schultz
8 months ago
🧪🌾 Fascinating and discouraging report on the growth of false science reports:
www.pnas.org/doi/abs/10.1...
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The entities enabling scientific fraud at scale are large, resilient, and growing rapidly | PNAS
Science is characterized by collaboration and cooperation, but also by uncertainty, competition, and inequality. While there has always been some c...
https://www.pnas.org/doi/abs/10.1073/pnas.2420092122
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Jess O'Thomson
9 months ago
This also wastes humanity's resources, btw. The fact that there is no publication of stuff that doesn't work means that a bunch of people can independently try the same failing approach without ever knowing what was done before them, or having any way to know. Over and over again.
add a skeleton here at some point
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Prof Sam Illingworth
9 months ago
🧪 Science Poem 🖋️ New research has found that climate change and cheese quality are closely linked – with drought reducing grass, altering milk, & muting flavour. Here's my poetic interpretation:
scienceblog.com/thepoetryofs...
#SciComm
🍎 🐄
#Poetry
#ClimateChange
#Cheese
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Cheese Weather
How does climate change affect cheese quality? This poem and explainer explore drought, feed, and flavour in traditional dairy farming.
https://scienceblog.com/thepoetryofscience/4379/climate-change-and-cheese-quality/
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Randall Munroe
9 months ago
Tukey
xkcd.com/3104/
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Saganism
10 months ago
Carl Sagan in 1986 on the problems with media and science literacy.
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Richard Sever
about 1 year ago
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers]
openrxiv.org
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Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
https://openrxiv.org/
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Joanna Thompson
about 1 year ago
So uhh…sorry for the nightmare fuel, but I wrote about how microplastics seem to be messing with photosynthesis. 🌏🧪
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https://www.scientificamerican.com/article/microplastic-pollution-is-messing-with-photosynthesis-in-plants/
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Zach Weinersmith
about 1 year ago
Me and Kelly in video form:
www.youtube.com/watch?v=oN_C...
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Why Elon Musk's plans to colonise Mars are bound to fail
YouTube video by Times Radio
https://www.youtube.com/watch?v=oN_CbqooDJs
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Dear
#ProtemicSky
community, I seek help! Anyone here working (preferably for a long time or extensively) on Exploris 480? I experience a peculiar problem on my machine and would appreciate any help (BTW, yeah, Thermo guys do not know what it is... at least yet)
about 1 year ago
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