A bit short notice but all in the vicinity of Edinburgh are most welcome (its open to non-Uni visitors) but I will post slides later (n.b. Honorary rather than the real thing but hey... :)

Anyone know (or has) a working webserver for the prediction of Cys palmitoylation? Ones I tried did not work or were Ser specific. By all means run this UrBACE sequence from Mylnosiga fluctuans (ORF within GGOI01019559) where you can see putative Cys in the oily tail #bioinformatics

Anyone tried this out? #savemetime

Does anyone have an (ideally testable) explanation for what is going on here? #bioinformatics #BACE1 #BACEevolution lnkd.in/d4dZT6wc

Indications of relative real-world utility of these would bgr8

Good to see this despite these being "difficult times" Will these be adopted by @ebi.embl.org EPMC?

From #NCBI Insight | #PMC Continues to Improve New Search | #OpenScience #Publications #OpenAccess #Education | 🧪 🔓 ⬇️ ncbiinsights.ncbi.nlm.nih.gov/2026/04/22/p...

Just when you were wating for Division of Medicinal Chemistry first disclosure annotation blogs two come along (even if separated by some months :) lnkd.in/YCMJGW

2026 greetings from Sweden 42166 :)

Good stuff but when can the results feed through to UniProt annotations?

Yes, I have noticed some of these contaminating my GS citations :(

Woo :)

Gosh, remember those "Mitchell and Moyle" experimental papers well back in day at Dundee

Last #greatcompoundrace of the year. 1) Elsevier | Life Sciences Reaxys stays out in front 2) Suggest CAS harmonise their web instances of different totals 3) Also suggest Royal Society of Chemistry ChemSpider puts total on front page (like it used to be) not just nested under "Promotion

Great to attend the ELIXIR-UK All-Hands recently in Exeter and present our UK resource The IUPHAR/BPS Guide to PHARMACOLOGY update lnkd.in/dMUfbbci which was also recently published in the latest NAR Nucleic Acids Research Database Issue (see lnkd.in/dmHapSie)

I know some people have had problems accessing the discord servers we use for the UGMs, so I'm trying an experiment with setting up a Zulip server for the #RDKit. If this works well, we can leave it up as an informal chat/discussion point for the community. rdkit.zulipchat.com/join/ay4ccup...

Looks like that top one is not in PubChem yet

So what was his final score? less than 99 I'm sure....

Amen, a PubChem pop takes seconds

Gosh, will this get me rich?

Disaster :((

Looking forward to presenting this on Wed 17 Sept uchealth.zoom.us/webinar/regi...

Fine, but that seaweed might whiff a bit....

Wow!

But gruniad website still free for now

ACS Washington presentation lnkd.in/dxvaQn9V A well attended joint CHAL & CINF session and thanks to Emilia Hietala and Collaborative Drug Discovery - CDD Vault

Nice to see a steady engagement increase for my blog lnkd.in/ebDNdfG :)

Pleased to attend American Chemical Society Washington next week with ACS CINF slots for "Update of InChIKey searching in Google" Aug 18 from 3:20 PM and "Mining the outputs of AI drug discovery from patents" August 21 9:05 (a CDD Vault collaboration)

Good idea mate...

Enjoyable break visiting my friend and leading Mosel Winemaker Franz-Peter Schmitz from Römerhof in Riol. Great to catch up on the wine technology, commerce and biochemistry as well as socially. New post pending as a follow on from a past blog cdsouthan.blogspot.com/2013/06/wine...

Couple of recent posts at cdsouthan.blogspot.com

Real shame 2c @acs.org capitulate to the MJB (mumbo jumbo brigade)

Good 2c a steady < over the last year but more engagement always welcome :) cdsouthan.blogspot.com

Refreshing Midsummer's day swim at Naset. Finally warm enough to get to second jetty when it was so cold last month I could only just make the first. We'll see how many weeks it takes to extend my efforts to the third jetty (red on right) and eventually ~550 m to get across the inlet (lower left)

Last day so please do the same (see LinkedIN posts from me and others for the link)

Broken DOI :(

Brocken/very slow link?

A targeted effort to find and isolate some of the most harmful papers from the medical literature:

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using @flybase.bsky.social please donate using the link in post below. This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

This was impressive :)

Will PDB be impacted? :(

Important survey very relevant to my own and @cindycrowninshield.bsky.social followers so please fill in and ping out

Webinar: My Federal Grant was Terminated: What to Do Now? 📅 May 8, 2025 | 🕒 3 PM ET Registration required: us06web.zoom.us/webinar/regi...

I could say the same about drawing out 100s of glass pippete tips during my Masters in Virology - but I wont :)

Mayday holiday stroll yesterday appreciating the emphatic arrival of spring here in Naset

Bit of self-doubt by DECIMER and no exact match in PubChem but looks like it whacks the right BMS patent "Pyridinyl substituted oxoisoindoline compounds" pubchem.ncbi.nlm.nih.gov/patent/WO-20...

Good 2C and now in @gtopdb.bsky.social curation que but odd that AVI-4773 C#CCN1C(=C(C(=O)N(C2=CN=CC3=C2C=CC=C3)C1=O)N4C5=C(C=CC=C5)N=N4)N is an orphan in PubChem sans patent hits

But spanner in the works?

Thoughts on Demis Hassabis of Google DeepMind saying that AI could cure disease in general in ten years. Bonus index to my longer posts on AI/computational drug discovery over nearly 20 years!