Ioannis (Yanni) Kipouros (@yannikipouros.bsky.social)

New paper led by postdoc @yannikipouros.bsky.social is out today in Nature! We show how metal coordination mining of AlphaFold reveals dozens of new radical halogenase families, including the promiscuous biocatalyst BtnX. #enzymes #bioinformatics #biocatalysis #secmet www.nature.com/articles/s41...

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Targeted enzyme discovery using metal-coordination mining - Nature A methodology for mining protein structure databases on the basis of the distinct intrinsic structures of metal-binding active sites in enzymes enables the discovery of new families of radical halogen... https://www.nature.com/articles/s41586-026-10716-z