Courtney Ellison
@ckellison.bsky.social
📤 153
📥 173
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Assistant Professor at the University of Georgia studying bacterial cell biology 🔬🧫🏳️🌈
reposted by
Courtney Ellison
Lori L. Burrows
about 2 months ago
New paper alert! We used our fav technique, genetic suppression, to understand how FimX controls function of the T4P PilB motor ATPase in Pseudomonas aeruginosa. Great collab with the Ellison lab at U Georgia who helped with some fancy microscopy to capture pilus dynamics!
doi.org/10.1371/jour...
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Twitching motility suppressors reveal a role for FimX in type IV pilus extension dynamics
Author summary Type IV pili enable Pseudomonas aeruginosa to attach to surfaces, move (twitch), and form biofilms. Pilus extension is powered by the motor protein PilB, which is regulated by other fac...
https://doi.org/10.1371/journal.pgen.1011802
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Excited to share the newest preprint from the lab for my first post! Driven by
@tayellisonwrites.bsky.social
and
@ianyyen.bsky.social
with Lynne Howell we show the protein FimX has diverged in function away from regulating pilus extension to instead regulate pilus localization in A. baylyi
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FimX regulates type IV pilus localization via the Pil-Chp chemosensory system in Acinetobacter baylyi
Type IV pili (T4P) are widespread dynamic appendages required for diverse prokaryotic behaviors including twitching motility, biofilm formation, and DNA uptake leading to natural transformation. Altho...
https://www.biorxiv.org/content/10.1101/2025.05.21.655318v1.article-metrics
7 months ago
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