Oliver
@oliverch77.bsky.social
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reposted by
Oliver
Dr. Jeroen den Dunnen
3 months ago
We already knew that severe acute
#COVID19
is induced by pathogenic IgG. But now Lynn Mes &
@oliverch77.bsky.social
show in
@eurjimmunol.bsky.social
that IgA2 adds even more fuel to the fire 🔥:
onlinelibrary.wiley.com/doi/10.1002/...
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Anti‐SARS‐CoV‐2 Spike IgA2 Induces Inflammation by Human Macrophages
Anti-SARS-CoV-2 spike IgA drives inflammation in human macrophages through FcαRI-Syk signaling. IgA2 immune complexes amplify cytokine production and alter glycolysis and mitochondrial function more ....
https://onlinelibrary.wiley.com/doi/10.1002/eji.70068
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