BalKrishna, PhD. (@krishb21.bsky.social)

Excited to share our latest co-first author review on the role of EC metabolism in vascular function, published in TEM! Explore the intricate metabolic pathways that drive EC biology and their implications for health and disease. www.cell.com/trends/endoc...

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Intracellular endothelial cell metabolism in vascular function and dysfunction Endothelial cells (ECs) form the inner lining of blood vessels that is crucial for vascular function and homeostasis. They regulate vascular tone, oxidative stress, and permeability. Dysfunction leads to increased permeability, leukocyte adhesion, and thrombosis. ECs undergo metabolic changes in conditions such as wound healing, cancer, atherosclerosis, and diabetes, and can influence disease progression. We discuss recent research that has revealed diverse intracellular metabolic pathways in ECs that are tailored to their functional needs, including lipid handling, glycolysis, and fatty acid oxidation (FAO). Understanding EC metabolic signatures in health and disease will be crucial not only for basic biology but can also be exploited when designing new therapies to target EC-related functions in different vascular diseases. https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760%2824%2900296-0