At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9 #MethodologyMonday #120

Interested in adaptive platform trials? INCEPT (www.incept.dk) recently got approved along with the first domain, and we expect to start inclusion soon. A protocol/design paper is available at doi.org/10.1111/aas.... along with the full protocol docs at incept.dk/documents @andersperner.bsky.social

This past month has seen the publication of a couple of new helpful papers providing further insights into the thorny issue of #MultipleTesting in trials 1/7 #MethodologyMonday #112

Good news for ICUs and patients The Intensive Care Platform Trial - INCEPT - was approved by the regulators INCEPT is a very broad domain based, adaptive platform trial assessing everyday interventions in ICUs 1. enrolled in first domain (albumin use vs no use in shock) in april 2025 incept.dk

An issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8 #MethodologyMonday #109

Interested in design and evaluation of advanced adaptive trial designs? See our new preprint: doi.org/10.48550/arX... Here we summarise key methodological considerations and how to specify and evaluate them using simulations via our 'adaptr' #Rstats package (inceptdk.github.io/adaptr/) 1/..

Interested in design and evaluation of advanced adaptive trial designs? See our new preprint: doi.org/10.48550/arX... Here we summarise key methodological considerations and how to specify and evaluate them using simulations via our 'adaptr' #Rstats package (inceptdk.github.io/adaptr/) 1/..

A Core Outcome Set for Adult General ICU Patients should include survival, free of life support, free of delirium, out of hospital, health-related quality of life, and cognitive function. Excellent international Delphi study from Denmark journals.lww.com/ccmjournal/f...

A core outcome set for general ICU patients aimed for clinical trials - developed with many stakeholder and internationally validated Amazing work by #INCEPT trial team led by @maj-brit.bsky.social with contribution from a large group of international colleagues journals.lww.com/ccmjournal/a...

In clinical research, you will often receive feedback on study design, stats, and/or data analysis from an editor or reviewer that is simply wrong. Here is a list of common "statistical myths" and references you can use to push back. discourse.datamethods.org/t/reference-...

This is a list of statistical myths and misconceptions that I keep coming back to. So many common avoidable mistakes. Should be read by all clinician researchers and all who want to critically read studies! #cardiosky #emimcc #stats