rdcu.be/e3me8 Virus and autoimmunity-another nail in the coffin...

New work on the mechanism by which certain deleterious (senescent-like) stromal cells evade immune clearance. www.biorxiv.org/content/10.6...

You don’t need AI. Why? Because you have the greatest natural learning system on the planet that evolved over billions of years, which is the immune system. www.statnews.com/2026/01/15/r...

Arena BioWorks, an ambitious biomedical institute backed by billionaires, abruptly shuts down www.statnews.com/2025/11/04/a... via @statnews.com

In @elife.bsky.social: Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment doi.org/10.7554/eLif...

The “valley of death” is getting increasingly treacherous with NIH in shambles and VCs increasingly training their money at clinical stage companies.

Another one bites the dust. www.fiercebiotech.com/biotech/novo...

It’s another blow to a cell therapy industry that has fallen out of favor as companies struggled to develop next-generation cell therapies that were both effective and could make the complex and expensive treatments more widely accessible. endpoints.news/takeda-stops...

Doesnt bode well for muscle preservation combo approach. www.reuters.com/business/hea...

What a phenomenal retrospective at SFMOMA

iPSCs are generated by reprogramming adult cells into a pluripotent state, similar to embryonic stem cells, but with the advantage of being derived from the patient's own cells, reducing the risk of immune rejection. What is the evidence this is true?

Congrats to Anil Bhushan @bhushanlab.bsky.social and Gregory Ku for receiving a 2025 Beatson Foundation Award for their projects "Targeting Pancreatic Stromal Cells to Halt T1D," and "Using Massively Parallel Monitoring of Insulin Secretion to Make a Better Stem cell-Derived β Cell," respectively.

It is increasingly recognized that immunosuppressive barriers within the tumor microenvironment present a major obstacle to the efficacy of checkpoint inhibitors and adoptive T cell therapies in patients with solid tumors.

Biomea joins the GLP1 bandwagon-what happened to the Menin inhibitor-a pivot or just changing subject? investors.biomeafusion.com/news-release...

Cells in a bag don’t work. The focus is now on immune suppression ftp.fiercehealthpayersummit.com/biotech/vert...

California state film tax credit doubled while money for scientific research SB 829, an investment that creates new jobs is rejected by senate appropriations. Where is the California that invents the future.

Taurine, a darling of longevity seekers, is found to be unreliable biomarker for aging www.statnews.com/2025/06/05/t... via @statnews.com

Sebastião Salgado, Acclaimed Brazilian Photographer, Is Dead at 81 www.nytimes.com/2025/05/23/a...

The reprogramming arms race-is it good for biotech?

While this is an interesting study in the morphology and heterogeneity of so called senescent cells by various inducers In vitro-what would be nice is to identify these cells in vivo in a disease tissue www.science.org/doi/10.1126/...

Xenopus leads the way-5-Formylcytosine is an epigenetic mark for RNA Pol III during zygotic reprogramming: Cell www.cell.com/cell/fulltex...

Stromal lymphoid organizing cells

On the way to the EMBO meeting

The new bistro car

Athol Fugard, South African political dissident playwright, dies aged 92

In venture capital(VC), the power law describes a distribution where a few investments generate the major of returns. VCs often invest in a broad array of startups, anticipating that while many yield modest returns, few will become “home runs,” providing large profits that define the fund’s success.

The VCs made their herding bets but “CRISPR’d medicines are a lousy business”Adam Feuerstein At least the current herding towards obesity has proven good business

As outcry builds over Trump cuts to NIH payments, drugmakers are MIA www.statnews.com/2025/02/11/n... via @statnews

We wanted science twitter and now we have it.

Chutzpah techcrunch.com/2025/01/24/r...

It’s easier to publish dubious science that aligns with conventional wisdom. www.nytimes.com/2025/01/24/o...

So what the general response to this one patient data? Does KO of B2M really make cells invisible? www.fiercebiotech.com/biotech/sana...

Google’s secretive anti-aging company Calico finally released data. Its drug failed www.statnews.com/2025/01/06/c... via @statnews.com

Creative Diplomacy In Brussels-North, announcements list which train is arriving in Dutch, followed by French. In Brussels-South, it is the other way round. And in Brussels-Central-even year, the announcements start in Dutch, during odd years they start in French.

Breakfast anyone?

It smells heavenly

It’s always sushi time.

Birds on a wire.

BioAge Labs Announces Discontinuation of STRIDES Phase 2 Clinical Trial Evaluating Azelaprag in Combination with Tirzepatide for the Treatment of Obesity www.globenewswire.com/news-release...

www.nature.com/articles/s41... Senescent cells are more susceptible to ferroptosis yet aging leads to resistance to ferroptosis Couple this with the inability to find senescent cells in aged mice.