Brooke O'Donnell
@brookeodonnell.bsky.social
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PhD👩🏼🔬🇨🇦 | Post-doctoral Fellow | Isakson Laboratory | CVRC University of Virginia 🧡💙 (she/her)
Thanks to @UVACVRC for the shoutout! Happy National Postdoc Appreciation Week 🎉
add a skeleton here at some point
29 days ago
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Brooke O'Donnell
Manuel F. Navedo
2 months ago
The official release of our manuscript examining arterial myocyte Panx1 role in diabetic vascular dysfunction is out! Massive effort to uncover new mechanisms underlying vascular disease. Power of science!
@ucdavis.bsky.social
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@ucdavispharm.bsky.social
www.ahajournals.org/doi/10.1161/...
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Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research
BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.125.326260?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
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Grateful to have been a part of this exciting story!
add a skeleton here at some point
3 months ago
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Brooke O'Donnell
Brant Isakson
6 months ago
Some of the strong work by Melissa Luse rounding her PhD. Love the story, and I think it opens up some new ideas in endothelial lipid handling and overall questions roles for NO…
www.ahajournals.org/doi/10.1161/...
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Nitrosation of CD36 Regulates Endothelial Function and Serum Lipids | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: During obesity, endothelial cells (ECs) become lipid laden, leading to endothelial dysfunction. We tested posttranslational modification on CD36 that may regulate EC lipid accumulation. ...
https://www.ahajournals.org/doi/10.1161/ATVBAHA.124.321964
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Was great to be back for the 13th Conference on Signalling in Normal and Cancer Cells to present my work on the effect of PANX1 phosphorylation in the vasculature 🍁 thanks to the organizers
@jf-cotelab.bsky.social
for a great week and my previous lab mates
@drsilviapenuela.bsky.social
for the visit!
7 months ago
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