Recent advances in #peptide-GPCR interactions are transforming drug discovery. This #Primer details experimental and computational approaches, from in silico peptide mining to modern biosensor assays, paving the way for novel therapeutics. www.nature.com/articles/s43...

Explore how generalized additive models for location, scale, and shape (GAMLSS) extend traditional regression by modeling mean, variance, and more. This #Primer highlights the role of distributional regression in risk assessment and predicting uncertainty. www.nature.com/articles/s43...

Conductive polymers (CPs) have unique optoelectronic properties and mechanical ductility. This #Primer discusses how these features make CPs suitable for next-gen optoelectronic and bioelectronic devices. www.nature.com/articles/s43...

Solid-state laser cooling has emerged as a promising alternative to traditional cryogenic methods. Check out this #Primer outlining the experimental considerations for laser cooling, emphasizing materials, cooling metrics, and thermometry. www.nature.com/articles/s43...

Matrix-assisted laser desorption/ionization imaging mass spectrometry (#MALDI IMS) enables detailed molecular mapping at cellular resolution. Check out the various mass analyzers and instrumental configurations in this new #Primer 🗺️ www.nature.com/articles/s43...

#Cucurbiturils are synthetic macrocycles that serve as molecular containers. This #Primer from @lyleisaacs.bsky.social, @connor-r-schmidt.bsky.social, @cakakpo.bsky.social and team explores their synthesis and applications in chemical sensing, drug delivery. www.nature.com/articles/s43...

In this #Primer, a variety of #enzyme-tethering techniques, such as DamID, ChIC, CUT&RUN, CUT&Tag, and RT&Tag are highlighted, emphasizing their suitability for single-cell and spatial applications in biological research. 🪢🧬 www.nature.com/articles/s43...

MgO-based magnetic tunnel junctions (MTJs) enhance spintronic applications through coherent spin-dependent tunnelling and significant tunnelling magnetoresistance. 🔄🧲Check out the #MTJ #Primer here: www.nature.com/articles/s43...

From the Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy, "It takes two combs to tango" www.eurekalert.org/news-release...

Explore the world of #dual-comb spectroscopy, where two optical frequency combs enable precise, rapid measurements without mechanical scanning. This #Primer covers its principles, performance, and future applications from terahertz to ultraviolet. www.nature.com/articles/s43...

Transient absorption (TA) spectroscopy offers a window into the dynamics of excited states in molecules and materials. This #Primer explores TA's role in tracking photoinduced processes with femtosecond precision. www.nature.com/articles/s43...

Flow NMR spectroscopy offers real-time monitoring of chemical reactions, providing quantitative and structural insights for catalysis, polymers, and more. This Primer is in memory of Jean-Nicolas Dumez, an outstanding scientist and friend lost too soon. www.nature.com/articles/s43...

This week's #Primer explores the capabilities of laser Doppler vibrometry (#LDV), an interferometric sensor that measures time-dependent displacements in challenging environments - such as from drones or on high-speed trains. 🔴🚆 www.nature.com/articles/s43...

What does a #ScientistAtWork look like? Maybe they look like you! Check out this photo competition and share your day in the life as a scientist 📸 www.nature.com/immersive/sc...

From @huailang.bsky.social, @eboyden3.bsky.social, and team comes a #Primer on #ExpansionMicroscopy, which enables imaging of nanoscale structures by enlarging samples within a hydrogel matrix. Check it out here! www.nature.com/articles/s43...

In our newest #Comment, the authors propose the plant-informed nanodesign (PIND) framework. This biology-driven approach aims to optimize nanoherbicides by aligning them with species-specific plant traits. 🌱 Check it out here 👇 www.nature.com/articles/s43...

A new #Primer this week from the Komor Lab at UCSD on #BaseEditing, a method for precise genome editing through programmable single-base changes. Base editing has application in high-throughput screening, disease modeling, and therapeutics. 🧬 www.nature.com/articles/s43...

Magnetoresistance, the change in electrical resistance of a material when exposed to a magnetic field, is used in a variety of applications, such as memory in hard disk drives! Learn more in this #Primer 🧲🧭 www.nature.com/articles/s43...

Are you interested in writing a short piece on a method you find interesting? Check out this collection from Nature Human Behavior for inspiration on how to write a "how to" Comment! www.nature.com/collections/...

Happy Friday! Enjoy our newest #Primer on #ultrafast nano-imaging and nano-spectroscopy for measuring nanoscale dynamics, such as coupled electron, spin, and lattice dynamics, with sub-wavelength resolution. www.nature.com/articles/s43...

The 2026 Nature Awards for Inspiring Women in Science call for entries is open! One winner in each category, Scientific Achievement and Science Outreach, will receive a $50,000 prize, networking opportunities and more.  Apply before April 8 here: go.nature.com/4qxGZoH #WomeninSTEM

Hyperspectral imaging (HSI) captures spatial and spectral data simultaneously, offering non-invasive insights into material properties. Our recent #Primer outlines HSI's workflow, data processing, and its role in Earth observation systems.🌎📷🌍📸🌏🎞️ www.nature.com/articles/s43...

From @milespadgett.bsky.social and team, is a #Primer on #quantumimaging using entangled photon pairs. ➰ Different modalities, such as ghost imaging and heralded imaging, can surpass the resolution of classical imaging methods. 👻🐈‍⬛📸 www.nature.com/articles/s43...

In this week's #Primer, discover how fluid force microscopy #FluidFM allows for precise manipulation and analysis at the nanoscale by combining AFM and microfluidic probes. ➿💧 www.nature.com/articles/s43...

Day 🔟 of the NRMP 5th Anniversary Highlights 🧁 Last, but not least, we chatted with @aronwalsh.github.io to learn more about the trends, opportunities, and challenges in using #AI for material design. 🌟 www.nature.com/articles/s43...

Our #Primer this week is on #electrophoreticdeposition, a method used to produce thin films from colloidal materials with electrode tuning. ⏺️🔋 Thanks to researchers @boccaccini-lab.bsky.social and SUS Tech for contributing to this piece! www.nature.com/articles/s43...

Day 9️⃣ of the NRMP 5th Anniversary Highlights 🧁 How and when are new chemical symbols developed and disseminated? We chatted with Brynn Hibbert from @iupac.org to learn more standardizing chemical symbols and nomenclature ✍️🗞️ www.nature.com/articles/s43...

Day8️⃣ of the NRMP 5th Anniversary Highlights 🧁 In each Primer, our authors must write on the reproducibility and data deposition available for their method. We explored this area further in a Q&A with Marcus Munafo of the UK Reproducibility Network 👉 www.nature.com/articles/s43...

Day 7️⃣ of the NRMP 5th Anniversary Highlights 🧁 As solar photovoltaics (PVs) are scaled-up at increasing rates, how should the sustainability of solar energy be addressed? This Comment provides practical steps for designing PVs with circularity in mind.🔆♻️ www.nature.com/articles/s43...

Day 6️⃣ of the NRMP 5th Anniversary Highlights 🧁 Continuing to address the advancement of #AI in methods, this Q&A discusses concerns such as quality, transparency, and reproducibility in AI-driven research. www.nature.com/articles/s43...

Day 5️⃣ of the NRMP 5th Anniversary Highlights 🧁 What's rugged, portable, and analytically precise? A Raman spectrometer, of course! This comment discusses how Raman spectroscopy can be adapted for use in extreme environments, like space. 🪐 www.nature.com/articles/s43...

Day 4️⃣ of the NRMP 5th Anniversary Highlights 🧁 With the rising influence of #AI, how should researchers best communicate their findings and what are the best avenues for the general public to read these results?

Day3️⃣ of the NRMP 5th Anniversary Highlights🧁 From @audreyalejandro.bsky.social at @lsemethodology.bsky.social comes a topic that everyone can reflect on, #reflexivity. Learn more about your bias and applying these realizations to your research 👇 www.nature.com/articles/s43...

Day2️⃣ of the NRMP 5th Anniversary Highlights 🧁 @clancyatheart.bsky.social and @masi-lab.bsky.social discuss the emerging role of digital twins, combined with AI, for biomedical research that can inform preclinical decisions. www.nature.com/articles/s43...

Day 1️⃣ of the NRMP 5th Anniversary Highlights 🧁 Joshua Patterson provides tips for designing undergraduate research projects. 🎓🏫 When undergraduates have limited time and expertise, how do you craft a project that will keep them engaged and successful? www.nature.com/articles/s43...

🔭 What’s the future of reflexivity & how do we put it into practice? New article in @natrevmethodsprimers.nature.com I argue for three priorities 1) evaluation criteria 2) studying reflexivity as a socio-cognitive phenomenon 3) adapting it across research traditions OA: rdcu.be/eX79L

This month, we are celebrating 5 years of Nature Reviews Methods Primers with a variety of Comments and Q&As that address recent advancements in methods!

This week, check out a new #Primer on #cryogenic electron tomography (cryo-ET) used for visualizing 3D structures of cells with sub-nanometer resolution. 🔬🧫 www.nature.com/articles/s43...

Explore the potential of #lidar in our latest #Primer, an active remote sensing technology that can consistently measure distances by emitting light from a laser source and recording the signal reflected from the target. www.nature.com/articles/s43586-025-00446-3

Our newest #Primer is on #spectroelectrochemistry (SEC), a method for studying redox-active interfaces in a UV-Vis spectral window. With this technique, redox stoichiometries and kinetics can be determined and analyzed. 🌈🔋https://www.nature.com/articles/s43586-025-00445-4

This week #Primer is on frontal #polymerization, a self-sustaining, energy-efficient method for polymerization! This technique is used in radical-induced cationic frontal polymerization and frontal ring-opening metathesis polymerization. Check it out here: www.nature.com/articles/s43...

This week's #Primer is on #ptychography, a lens-free approach to high-resolution imaging across wavelengths, from electron to visible light. Learn about the theory, reconstruction algorithms, and applications in life and materials science here! 💡📏 www.nature.com/articles/s43...

Our #Primer this week is on #atomic layer #deposition (or #ALD) a method for creating thin films with controlled thicknesses by depositing materials one atomic layer at a time. Check it out here: 👇⚛️📽️🟰 www.nature.com/articles/s43...

If you'd like to learn more about #Fouriertransform, after reading the #macromolecularcrystallography Primer, check out this #Primer, highlighting the theory behind the Fourier transform and its applications in mass spectrometry, NMR spectroscopy, and IR spectroscopy. www.nature.com/articles/s43...

This week's #Primer features a breadth of knowledge and tips for interpreting the diffraction data from #macromolecularcrystallography. There's also an in-depth discussion about the impact of resolution and errors in the Fourier Transform for crystallography. ↘️💠↗️

A new #Primer this week covers #ultrafast #TEM - a technique that femtosecond resolution of coherent phenomena in #quantum materials. ⚡⏩ Check out it's variety of setups and applications here: www.nature.com/articles/s43...

In many chemistry articles, authors will claim that a process is "greener" than conventional syntheses - but what does that claim really mean? Our newest #Comment discusses green chemistry metrics and the future for designing sustainable chemical reactions. 📗🧪 www.nature.com/articles/s43...

From @paradisireslab.bsky.social and team, we have a #Primer this week on #flowbiocatalysis - a technique that combines the power of enzyme catalysis with the efficiency of flow chemistry! 🧬🧪🫗 www.nature.com/articles/s43...

This week's #Primer is about metal-organic chemical vapour deposition, a useful technique for tailoring the growth of 2D materials, such as transition metal dichalcogenides and other heterostructures. 📈🧑‍🔬📐 Check it out here! www.nature.com/articles/s43...

Check out this week's #Primer on #Time-domainthermoreflectance a pump-probe technique for measuring heat transfer, including thermal conductance, in materials like thin films or semiconductors. 🌡️♨️ www.nature.com/articles/s43...