Our “zoo experiment” in Cell Reports @cellpress.bsky.social shows that extracellular cytokine molecules are encoded by surface receptors as quantized signaling units, independent of ligand affinity. A new principle for how cells sense and interpret their environment. www.cell.com/cell-reports...

In the complex world inside our bodies, timing can be everything. A new study from Steven Smeal and Robin E.C. Lee reveals the timing of molecular signals can change how cells respond to their environment, with implications for cancer treatment and drug discovery. Read more: rdcu.be/ezTxF

In @natcomms.nature.com, we used robot-controlled cytokine pulses and imaging single receptor complexes and TF dynamics reveal that repeat, dose-conserving stimulation prolongs NEMO/IKK activation and shifts NF-κB dynamics via chromatin remodeling, enabling accurate single-cell models rdcu.be/ezTxF

Thrilled to see our latest work online in Nature Communications rdcu.be/ezTxF! Congratulations and thanks to @cmupittcompbio.bsky.social PhD student Steven Smeal and all the co-authors for their critical contributions.

When a bovine cytokine talks to a human cell: Lessons from cross-species signaling experiments. 😊 🐱 🐰 🐁 🐀 🐄 www.biorxiv.org/content/10.1...