The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology. Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at [email protected]. Fee waivers and bursaries available. ! Please share widely !

The place where I work is hiring an expert in AI applied to the de novo design of proteins: urls.fr/DpLCMY Excellent structural biology environment, amazing city surrounded by mountains.

New preprint in the lab combining what we like best: insects, love, chemistry and the olfactory system! 1/8 www.biorxiv.org/content/10.1...

Solène’s 4.5 years of postdoctoral work in our lab (she started just before the corona pandemic) has now been published. A heroic effort that revealed -at the single molecule level- that ATP drives the dissociation of an ECF transporter complex under turnover conditions. See rdcu.be/elTKc

🧪 Question for ion channels people: is it possible to use the membrane potential-sensitive FLIPR dyes in cytometry? Any protocol or reference to get started?

I used to love science fiction, and some books describing AI-governed worlds left a lasting impression on me (Ian M Banks, John Varley, ...). I enjoyed this short story about AI takeover, despite - or perhaps because of - its dead-serious academic tone. ai-2027.com

New preprint! @tatilab.bsky.social imaged the honeybee GABAA RDL receptor. ~10% of insecticides target insect GABAA receptors. She found a new allosteric modulation pocket, a PIP2 site, a closed avermectin-bound conformation, and maybe an unusual desensitized state. www.biorxiv.org/content/10.1...

New preprint describing a primed nicotinic receptor state with only one agonist bound, seen at low [agonist]. My fav part: ~7% of particles are in that state on cryoEM grids... that's also the proportion predicted from the fitting of single-channel data! Work led by @mackthompson88.bsky.social

What examples would you include in a short lecture on transporters? My current ones are P4-ATPase and EAATs. Suggestions involving different techniques on top of multistate cryoEM particularly appreciated!