Vincent Pascat (@vpascat-biostat.bsky.social)

Polygenic scores are useful for early detection, but also early prevention! New paper shows people with high genetic risk of T2D have 3x more risk of developing it by age 35. Early detection could trigger lifestyle changes, metformin prescription... doi.org/10.1038/s414...

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Preventing premature deaths through polygenic risk scores - Nature Communications Via an integrative modelling approach that combines population and clinical trial data, the authors find that polygenic risk score-based screening would reduce premature mortality across seven commonl... https://doi.org/10.1038/s41467-025-68129-x