Øyvind Myrvoll Lorentzen
@oeyvindml.bsky.social
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MD PhD. Interested in infectious diseases, biofilms, bacterial evolution and adaptation and AMR.
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Øyvind Myrvoll Lorentzen
John Dennehy
about 2 months ago
Capturing dynamic phage–pathogen coevolution by clinical surveillance "we capture the acquisition of a parasitic anti-phage mobile genetic element, PLE11, that initiated a selective sweep coinciding with the largest cholera outbreak in recent records. "
www.nature.com/articles/s41...
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Capturing dynamic phage–pathogen coevolution by clinical surveillance - Nature
The acquisition of a parasitic anti-phage mobile genetic element, PLE11, showing potent anti-phage activity against cocirculating ICP1, and the subsequent evolution of ICP1 to escape this defense, are...
https://www.nature.com/articles/s41586-026-10136-z
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Øyvind Myrvoll Lorentzen
Alberto HCA
2 months ago
Excited to share our latest work! 📝 We measured the fitness effect of 136 AMR genes and found that many are neutral or even beneficial without selection. 🤯🧬 Oxygen availability can flip their fitness and our stochastic model indicates that oxygen fluctuations help maintain them. Learn more 👇🏼
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Kimberly Kline 🏔
3 months ago
What if quorum sensing doesn’t promote biofilms - but restrains it? 🤔 New work from
@harisantypas.bsky.social
shows that the Fsr QS system in Enterococcus faecalis acts as a brake on biofilm formation and pathogenesis during infective endocarditis (IE).
www.nature.com/articles/s41...
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Loss of Fsr quorum sensing promotes biofilm formation and worsens outcomes in enterococcal infective endocarditis - Nature Communications
Infective endocarditis (IE) is an understudied biofilm-associated infection. Here, analyses of preclinical and clinical data reveal that the Fsr quorum sensing (QS) system of Enterococcus faecalis is ...
https://www.nature.com/articles/s41467-026-68366-8
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Øyvind Myrvoll Lorentzen
Christopher Frøhlich
3 months ago
Sometimes, adaptation to one
#antibiotics
can make bacteria more vulnerable to other drugs.
#CollateralSensitivity
. 💡 By following the evolution of a β-lactamase, we uncovered how mutations can both create and mitigate such collateral sensitivity networks.
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.02.12.705688v1
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Jerónimo Rodríguez-Beltrán
3 months ago
New paper out in
@pnas.org
, and it made the cover! 👁️ We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally 𝑤𝑎𝑡𝑐ℎ plasmids evolve. ‼️Check Paula’s 🧵 and the paper👇 𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 𝘀𝗰𝗮𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝗼𝗽𝘆 𝗻𝘂𝗺𝗯𝗲𝗿
www.pnas.org/doi/10.1073/...
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Klebsiella Club
4 months ago
We’re excited to kick off a new season of the Klebsiella Seminar Series, held on Thursdays in April 🧫🧬! We have 3 sessions on pathogenesis, pediatric Klebsiella & translational approaches. We will also have an open session. Registration is mandatory & FREE in this link
forms.gle/LhJu11WQN6Yy...
🔁
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Last project of my PhD is out as a preprint!
add a skeleton here at some point
about 1 year ago
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