Capturing dynamic phage–pathogen coevolution by clinical surveillance "we capture the acquisition of a parasitic anti-phage mobile genetic element, PLE11, that initiated a selective sweep coinciding with the largest cholera outbreak in recent records. " www.nature.com/articles/s41...

Excited to share our latest work! 📝 We measured the fitness effect of 136 AMR genes and found that many are neutral or even beneficial without selection. 🤯🧬 Oxygen availability can flip their fitness and our stochastic model indicates that oxygen fluctuations help maintain them. Learn more 👇🏼

What if quorum sensing doesn’t promote biofilms - but restrains it? 🤔 New work from @harisantypas.bsky.social shows that the Fsr QS system in Enterococcus faecalis acts as a brake on biofilm formation and pathogenesis during infective endocarditis (IE). www.nature.com/articles/s41...

Sometimes, adaptation to one #antibiotics can make bacteria more vulnerable to other drugs. #CollateralSensitivity. 💡 By following the evolution of a β-lactamase, we uncovered how mutations can both create and mitigate such collateral sensitivity networks. www.biorxiv.org/content/10.6...

New paper out in @pnas.org, and it made the cover! 👁️ We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally 𝑤𝑎𝑡𝑐ℎ plasmids evolve. ‼️Check Paula’s 🧵 and the paper👇 𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 𝘀𝗰𝗮𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝗼𝗽𝘆 𝗻𝘂𝗺𝗯𝗲𝗿 www.pnas.org/doi/10.1073/...

We’re excited to kick off a new season of the Klebsiella Seminar Series, held on Thursdays in April 🧫🧬! We have 3 sessions on pathogenesis, pediatric Klebsiella & translational approaches. We will also have an open session. Registration is mandatory & FREE in this link forms.gle/LhJu11WQN6Yy... 🔁

Last project of my PhD is out as a preprint!