BindCraft can be used to design synthetic protein binders with incredible accuracy and success rate - Out now in Nature. BindCraft displays perfectly how AI-based tools can be used to accelerate biological research (and clinical applications). I think this is a must-read paper.

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

Out now: Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA cell.com/molecular-ce... Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein?

A PhD position is open for this year. A candidate should have a background in programming skills.

#Argonautes2025 update ... it will happen this August (27-30) @imgprague.bsky.social. Our ITs are finishing and testing the website, the registration will open on March 1st. More info will be provided later (once all speakers reply to my e-mail, just saying, not pushing 😁). Poster announcement:

🚨New review🚨 Evolution and ecology of anti-defence systems in phages and plasmids Link: www.cell.com/current-biol...

Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems (cell.com/cell-reports... It started with a simple question: Are certain prokaryotic immune systems always (or never) encoded with specific DNA repair proteins?...

New paper alert! Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems www.cell.com/cell-reports... Together with @sumanthmutte.bsky.social, Pilar Bobadilla Ugarte, and Daan Swarts.

Did you know that no natural inhibitors of prokaryotic Argonautes have been described (yet)? Together with @martinpacesa.bsky.social and Lennart Nickel, we designed our own de novo pAgo inhibitors! Check out these and other de novo protein designs in the updated Bindcraft preprint!

Such a powerful protein binder design pipeline, and now with even more useful applications! Like guiding AAVs to specific cell surface receptors, neutralizing allergens, and inhibiting nucleases like Cas9 and pAgo!