Aya Ludin (@ayaludin.bsky.social)

CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success CD8+ T cells preferentially engage tumor cells in pockets termed CRATERs, which are rich with antigen presentation molecules and breach into the tumor mass from the stromal compartment. CRATERs expand and become the major site of tumor killing during immune-stimulatory treatment, and their expansion parallels clinical benefit in patients undergoing immunotherapy. http://dlvr.it/TNkk9G