Solidifying findings in our pilot journals.sagepub.com/doi/10.1177/... at scale www.nature.com/articles/s41... #KidneyDisease #CKD #HeartRateVariability #CVD #CardiovascularResearch #DigitalMedicine #DigitalBiomarker #TranslationalScience

How is #BrainDevelopment linked to the emergence of #MentalHealthDisorders? Harmonizing & sharing #Neuroimaging data & well-defined psychiatric phenotypes are essential building blocks to pursue answers: doi.org/10.1016/j.ne... @sattertt @pennlinc.bsky.social #TranslationalScience

Refining first-in-human dual-targeting chimeric antigen receptor (CAR)-T cells for #Glioblastoma with real-time #Organoid modeling. doi.org/10.1016/j.st... #Cancer #CARTcelltherapy #TranslationalScience

Speech & Age: Vocal fold tissue remodeled from infancy to maturity. Key proteins influence biomechanics, paving the way for new treatment approaches for voice disorders. doi.org/10.1080/0300... @RicGottardi @Bio2GottardiLab #TranslationalScience

Common nanoparticle linkers may hijack the #ImmuneSystem, drive toxicity and misdirect #DrugDelivery. However, @jakebrenner lab uncovers molecular mechanisms & develops solutions to mitigate these effects doi.org/10.1002/adma... #Nanomedicine #TranslationalScience

Personalizing therapeutic modalities for #Glioblastoma through modelling routine care data, led by @chrisdav66. Check out doi.org/10.1093/neuo... @glioblastf @glioblastomaorg #NeuroImaging #TranslationalScience

Extending the #OrganOnAChip technology to mimic #BoneMarrow enabling mechanistic studies on injury models, #DrugToxicity, and more. Check out doi.org/10.1016/j.st... @PennEngineers #PennEngineering #TranslationalScience

Shift in understanding: Progenitor capacity of pulmonary venous endothelial cells drives #LungInjury repair doi.org/10.1038/s441... #PulmonaryFunction #LungHealth @vaughandy.bsky.social #TranslationalScience

Nervous when the next #Seizure in seizure-prone #Neonates will strike? Predictive modeling finetunes necessary #cEEG duration to identify electroencephalographic seizures for various risk profiles: onlinelibrary.wiley.com/doi/10.1111/... #NICU #TranslationalScience

Promising leads in therapeutic advances for metabolic dysfunction-associated steatotic #LiverDisease (#MASLD) doi.org/10.1016/j.cm... @WellenLab

Advancing our understanding of immunogenic epitope selection, with implications for #VaccineDevelopment and T cell–based therapies. doi.org/10.1073/pnas... #CryoEM @moiseenkovabell #TranslationalScience

Check this out! Monitoring the spatiotemporal dynamics of #mRNAvaccine antigen expression in vivo www.nature.com/articles/s41... @drewweissmanlab.bsky.social #TranslationalScience

Rewiring exhausted T cells to create therapeutic innovations for #ChronicInfections & #CancerTreatment doi.org/10.1126/scii... @ejohnwherry.bsky.social #ImmuneHealth #TranslationalScience

Early nonresponse to behavioral obesity treatment doesn’t have to mean failure. Adding anti-obesity medication doubles weight loss. doi.org/10.1038/s415... #ObesityResearch #WeightLossScience #TranslationalScience

#CRISPR/Cas9 gene editing establishes preclinical platform to evaluate #IsletTransplantation & #DrugDiscovery approaches doi.org/10.2337/db23... @kkaestner.bsky.social #DiabetesResearch #IsletBiology #TranslationalScience

Key metabolic enzyme tied to alcohol consumption discovered with #DrugDevelopment opportunities but maybe only for males doi.org/10.1016/j.ne... @berger_lab #AddictionResearch #AlcoholUseDisorder #TranslationalScience

Novel non-anticoagulant therapeutics to curb the immune response in Heparin-Induced #Thrombocytopenia #HIT doi.org/10.1182/bloo... #DrugDevelopment #TranslationalScience

Comprehensive study linking #Aging, #Diet, #Health and #HostGenetics in the #Microbiome doi.org/10.1038/s415... @ChristophThaiss @ThaissLab #TranslationalScience

Translating mechanistic insights from #Telomeropathies into therapeutic opportunities doi.org/10.1172/JCI1... @daria-babushok.bsky.social #TelomereBiologyDisorders #RareDiseases #TranslationalScience

Characterizing molecular programs guiding #CardioPulmonary maturation through integration of #SpatialTranscriptomics with #Computational #CellTrajectory analysis and #TranscriptionalProfiling doi.org/10.1016/j.ce... #CellAtlas #TranslationalScience

105 new loci at #genome-wide significance linked to 5 distinct traits/diseases with shared #GeneticSusceptibility to #HeartFailure doi.org/10.1038/s415... @DavidSMLee @bvoight28.bsky.social @MarylynRitchie @damrauer #TranslationalScience

Profound shifts in tumor and immune cell subpopulations after high-risk #Neuroblastoma therapy with signaling in HB-EGF–ERBB4 axis between macrophage and neoplastic subsets doi.org/10.1038/s415... #SingleCell #TranslationalScience

Mapping the brain’s complexity of genetic and neuroanatomical heterogeneity simultaneously doi.org/10.1038/s414... #BrainImaging #Genomics #Neuroscience #TranslationalScience

#RedBloodCells (RBCs) display mechanically active role in contraction of #BloodClots: Platelet-depleted clots formed in the presence of RBCs exhibited >20% volume shrinkage 10.1182/bloodadvances.2024015533 #Thrombosis #Hemostasis #TranslationalScience

CHAC1 emerging as #KidneyDisease #RiskGene with a central role of modulating tubule cell glutathione and #Ferroptosis doi.org/10.1126/scit... @ksusztak.bsky.social‬ #DrugDevelopmentOption #TranslationalScience

Targeting #Lung #EndothelialCells & #EpithelialCells through #LNPtechnology without off-target editing in the liver offers #DrugDevelopment pubs.acs.org/doi/10.1021/... @MJMitchell_Lab #LipidNanoparticles #Nanomedicine #TranslationalScience

Waking up after #Anesthesia: Neuronal dynamics model predicts both population- and individual-level features of emergence doi.org/10.1016/j.bj... #Anaesthesia #Anesthesiology #Anaesthesiology #TranslationalScience

Expanding the toolbox for #ProteinTagging: #Posttranslational #ProteinEditing in living #MammalianCells allows classic cell biology experiments while retaining #ProteinFunction www.science.org/doi/10.1126/... @BurslemLab #TranslationalScience

Expanding the toolbox for #GeneTagging: Higher antitumor efficacy & lower #GenoToxicity of Cas9 nickase–based adenine-base editing vs to nuclease-active Cas9 opens avenues to improve #CARTcelltherapy doi.org/10.1073/pnas... @carlhjune #TranslationalScience

Elucidating donor-specific #Thrombus growth through #Computational #3Dmodelling of #Platelet calcium mobilization, motion & bonding, agonist release & blood velocity field doi.org/10.1371/jour... #Atherosclerosis #TranslationalScience

World’s first: Gene editing clinically deployed for breakthrough treatment of rare genetic disease led by @kiranmusunuru & Rebecca Ahrens-Nicklas www.nejm.org/doi/full/10.... #GeneEditing #CRIPR #OrphanDisease #CPS1deficiency #TranslationalScience

Discovering molecular lever that controls whether liver stores energy as fat or glycogen. Tuning this switch could open new paths to tackle #MetabolicDisorders. doi.org/10.1126/scia... #Ppp1r3b #HepaticMetabolism #TranslationalScience

Tissue-specific loss of #Tregs and rise of stem-like CD8+ T cells prior to the onset of #TypeIDiabetes may offer promising window for early intervention doi.org/10.1038/s414... @BettsLab #Diabetes #T1D #ImmunePhenotype #Autoimmunity #TranslationalScience

Hope for children with #CLN2disease: #GeneTherapy enables steady-state protein delivery to the CSF in preclinical models doi.org/10.1126/scit... #LysosomalStorageDisorders #RareDisease #OrphanDrugs #TranslationalScience

Cortical spreading depolarization (CSD) discovered as second brain event following controlled seizure induction during #ElectroconvulsiveTherapy (ECT) for #TreatmentResistantDepression doi.org/10.1038/s414... #MentalHealth #TranslationalScience

Dissecting effects of #psychedelics at the cellular level to understand their therapeutic potential in #NeuropsychiatricDisorders www.nature.com/articles/s41... #MentalHealth #PTSD #Depression #SubstanceUseDisorder #TranslationalScience

Pairing high-resolution cryo–electron microscopy & tomography to design the next-generation broad-spectrum anti-influenza therapeutics www.science.org/doi/10.1126/... @yiweichang.bsky.social‬ #Flu #FluVirus #CryoEM #CryoET #TranslationalScience

Engineering genetic approaches to develop a CAR-T cell therapy efficaciously targeting #SolidTumor doi.org/10.1016/j.cc... @DJPowellLab #NeoCARs #CellTherapy #CARTCell #GeneTherapy #ImmunoTherapy #Oncology #TranslationalScience

Building the foundation to address the mechanistic gap between two hallmarks of #Neurodegeneration: excitotoxicity and RNA regulation by #RNA #BindingProteins (RBPs). doi.org/10.1016/j.is... @KJSsci #NeuroSci #MolecularBiology #TranslationalScience

Unraveling the often undefined pathogenesis of #MyxomatousValveDisease (MVD) doi.org/10.1172/JCI1... #SignalingMechanism #ValveDisease #HeartValve #CardiacHealth #TranslationalScience

How do biological systems interact with foreign materials? How is decision-making reflected in biological signaling networks? Using complement activation as a model system doi.org/10.1016/j.ce... dives into these questions @jakebrenner #TranslationalScience

Exploring the potential to restore physiologic islet function through fully differ¬entiated, allogeneic pluripotent stem cell–derived islet-cell therapy for #Type1Diabetes www.nejm.org/doi/10.1056/... #StemCell #CellTherapy #TranslationalScience

Broadening clinical utility of #CARTcelltherapy through in vivo engineering targeted lipid nanoparticles (tLNPs) for messenger RNA delivery to specific T cell subsets doi.org/10.1126/scie... @carlhjune @Haig_Ag #CellTherapy #CARTCell #TranslationalScience

#AdolescentBrain: #SexDifferences in the spatial organization of functional #Brain networks accentuated in association networks especially in frontoparietal & ventral attention networks doi.org/10.1192/bjp.... #MentalHealth #TranslationalScience

Discerning underlying mechanisms linking loss in the methyltransferase DOT1L activity to #NeurodevelopmentalDisorders (#NDDs) doi.org/10.1093/brai... #MentalHealth #Neurology #TranslationalScience

Developing biomarkers to differentiate between #Parkinsons disease (PD) and dementia with #LewyBodyDisease: Implications for #α-synuclein (aSyn) misfolding & aggregation doi.org/10.1002/ana.... @alicechenplotkin.bsky.social‬ #NeuroDegeneration #Neurology #TranslationalScience

Penn Medicine #BioBank growing its impact: Discerning early aortic #aging from imaging data with links to adverse #CardiacRemodeling and poor #CardiovascularOutcomes www.ahajournals.org/doi/10.1161/... @ThePMBioBank #PMBB #TranslationalScience

Examining mechanisms relevant for restoring #Erythropoiesis & mitigation of pro-inflammatory IFNγ action in #MouseModel #Anemia of #Inflammation (AI) doi.org/10.1182/bloo... #TranslationalScience

#Neuropeptides essential for complex social behavior with phenotypic plasticity in social insect model doi.org/10.1016/j.ce... #SocialAnalysis #SocialHierarchy #TranslationalScience

Cardiotropic #DrugDelivery system: Proof-of-concept for #LipidNanoparticles targeting cardiomyocyte-specific SERCA2A to modulate contractility & relaxation www.pnas.org/doi/10.1073/... #siRNA #Myocardium #TranslationalScience