@juliusbogo.bsky.social
đ€ 49
đ„ 123
đ 26
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Excited to share our new paper on a PKN biosensorâand how to build more! We only have a handful of kinase biosensors out there; now that ExRai backbone @jinzhanglab âanything you can do I can do betterâ for excising sensors real bottleneck is finding new substrates.
go.nature.com/42rUgpO
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Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N - Communications Biology
Development of genetically encoded fluorescent biosensor allows real-time visualization of PKN kinase activity, revealing sustained activity at the plasma membrane and demonstrating a new approach for...
https://go.nature.com/42rUgpO
over 1 year ago
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I made ConwayâMaxwellâBinomial regression on
#TMB
+
#glmmTMB
. A bounded-count family that handles both over- and under-dispersion through one parameter.. Demo on coral fertilization data from
@benoitpujol.bsky.social
#rstats
#STEM
#biology
jbogomolovas2.github.io/Julius-s-Blo...
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ConwayâMaxwellâBinomial regression: two-directional dispersion for bounded counts â Juliusâs Blog
Data Science, Swimming Analytics, and R Programming
https://jbogomolovas2.github.io/Julius-s-Blog/posts/CMB_regression/
6 days ago
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If you need to compare numbers of proliferating cells, ditch the t-test and go for count regression. You're more likely to get p < 0.05 when a real difference is there. I crunched the numbers:
#rstats
#statistics
#biostats
#ScienceSky
#AcademicSky
#biology
jbogomolovas2.github.io/Julius-s-Blo...
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ConwayâMaxwellâPoisson vs Welchâs t-test for proliferation count data â Juliusâs Blog
Data Science, Swimming Analytics, and R Programming
https://jbogomolovas2.github.io/Julius-s-Blog/posts/comparison/
10 days ago
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Hierarchical Bayesian models are easier than they sound. I used one to ask whether some Lithuanian news outlets are more negative than others. The naive answer was wrong; partial pooling fixed it. brms + ordinal regression on 4,832 headlines.
jbogomolovas2.github.io/Julius-s-Blo...
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âAnd Iâm looking for the funniesâ: sentiment in Lithuanian news headlines â Juliusâs Blog
Data Science, Swimming Analytics, and R Programming
https://jbogomolovas2.github.io/Julius-s-Blog/posts/sentiment_analysis/
27 days ago
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reposted by
MĂ„ns Thulin
over 1 year ago
Looking for a book that covers both statistics and R programming? Check out my book Modern Statistics with R! Coding, visualisation, regression, ML & more. đ Read it for free:
www.modernstatisticswithr.com
đ Get printed copies:
tinyurl.com/mswrbook
#Rstats
#statistics
#datascience
#machinelearning
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Your weight has a weekly cycle and a yearly cycle. 3 years of daily weigh-ins confirm it: Monday heaviest â Thursday lightest January heaviest â September lightest New blog post breaking it all down with GAMs in R:
jbogomolovas2.github.io/Julius-s-Blog/posts/weight_fluctations/
#rstats
#datascience
about 2 months ago
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reposted by
Nur Shahir, PhD (Hire me!)
2 months ago
Goals for my blog - a mini-series on the microbiome - recap of my experience with NLP - posting my posit:conf experience as a virtual participant (I have.....one post drafted and I think I may have been over ambitious đ„Č)
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Best way to learn something is to use it on a problem you care about. I've been getting into GAMs, so I built a swim base pace tracker â something
#Garmin
doesn't offer.
#rstats
#dataviz
#swimming
jbogomolovas2.github.io/Julius-s-Blog/posts/swim-css-pipeline/
about 2 months ago
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Our latest paper is out. We show that smaller is sometimes better- by trimming out a large portion of the
#ALPK3
kinase we create a functional miniALPK3 that fits into an AAV vector and treats ALPK3 cardiomyopathy.
doi.org/10.1161/CIRC...
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American Heart Association Journals
https://doi.org/10.1161/CIRCULATIONAHA.125.074632
6 months ago
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It was fun distraction to participate International Cherry Blossom Prediction Competition organized by
@georgemasonu.bsky.social
. Not the winner, but not shabby for a first try.
jbogomolovas2.github.io/Julius-s-Blo...
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Cherry Bloom Prediction â Juliusâs Blog
Data Science, Swimming Analytics, and R Programming
https://jbogomolovas2.github.io/Julius-s-Blog/posts/cherry_post/
11 months ago
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1
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reposted by
Our new paper in
@commsbio.bsky.social
. We show that Tnnt2 intronic RNAscope probe reliably identifies cardiomyocytes âeven through mitosis and nuclear envelope breakdownâovercoming the limitations of traditional CM identification methods.
www.nature.com/articles/s42...
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Intronic RNAscope probes enable precise identification of cardiomyocyte nuclei and cell cycle activity - Communications Biology
Intronic RNA probes precisely identify cardiomyocyte nuclei or chromatin throughout the cell cycle during embryonic cardiomyocyte proliferation and precisely identify cardiomyocyte nuclei in adult hea...
https://www.nature.com/articles/s42003-025-08012-z
about 1 year ago
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Our new paper in
@commsbio.bsky.social
. We show that Tnnt2 intronic RNAscope probe reliably identifies cardiomyocytes âeven through mitosis and nuclear envelope breakdownâovercoming the limitations of traditional CM identification methods.
www.nature.com/articles/s42...
loading . . .
Intronic RNAscope probes enable precise identification of cardiomyocyte nuclei and cell cycle activity - Communications Biology
Intronic RNA probes precisely identify cardiomyocyte nuclei or chromatin throughout the cell cycle during embryonic cardiomyocyte proliferation and precisely identify cardiomyocyte nuclei in adult hea...
https://www.nature.com/articles/s42003-025-08012-z
about 1 year ago
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3
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Our paper on
#ALPK3
is out in JAHA. We demonstrate that loss of ALPK3 and established factor for genetic cardiomyopathy leads to accumulation of thick filament components, possibly via MuRFs - muscle specific E3 ubiquitin ligases.
doi.org/10.1161/JAHA...
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α Protein Kinase 3 Is Essential for Neonatal and Adult Cardiac Function | Journal of the American Heart Association
https://doi.org/10.1161/JAHA.124.039464
about 1 year ago
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If it ain't green and glow in the dark it ainât
#science
. Leftovers from
#mClover3
fluorescent protein purification
about 1 year ago
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New work on how and when Indo-europeans emerged. Nice to see how Marijas Gimbutas Kurgan hypothesis has been verified using ancient DNA approach and new insights and details obtained.
add a skeleton here at some point
over 1 year ago
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Very likely successful cloning of HDR template for knock-in (ccdB present in source plasmid, sequencing pending). Still got the cloning touch! đ§Ź
#KeepCalmAndCarryOn
over 1 year ago
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reposted by
Addgene
over 1 year ago
Hey Bluesky! If you're an Addgene fan, you might want to sign up for our quarterly newsletter. Each edition contains the latest Addgene news, hot plasmids, new viral vectors, and a coupon. Click the link below to browse old editions and join our mailing list!
www.addgene.org/news...
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Addgene: Newsletters from Addgene
Read Addgene's quarterly newsletters which include information on the latest molecular biology techniques, articles, and plasmids in our collection.
https://www.addgene.org/newsletter/
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Small but mighty .đŠâđ„
over 1 year ago
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Excited to share our new paper on a PKN biosensorâand how to build more! We only have a handful of kinase biosensors out there; now that ExRai backbone @jinzhanglab âanything you can do I can do betterâ for excising sensors real bottleneck is finding new substrates.
go.nature.com/42rUgpO
loading . . .
Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N - Communications Biology
Development of genetically encoded fluorescent biosensor allows real-time visualization of PKN kinase activity, revealing sustained activity at the plasma membrane and demonstrating a new approach for...
https://go.nature.com/42rUgpO
over 1 year ago
2
12
2
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