Iqbal Ike K. Ahmed, MD, Jawad Muayad, MD, and Neil Bressler, MD, discuss a US cohort study indicating that patients who had documented nicotinamide use showed lower rates of glaucoma diagnosis, topical therapy, and laser intervention. 🎧 Listen now: ja.ma/4f4EBkQ

After refractive surgery, 18% of patients experienced prolonged ocular pain at 3 or 6 months, with higher risk seen after photorefractive keratectomy and in patients with preoperative chronic pain or greater ocular symptom burden. ja.ma/4yhUInT

Systemic #Nicotinamide supplementation in patients with #OcularHypertension was associated with a lower risk of developing primary open-angle #Glaucoma and delayed need for medical or surgical intervention. ja.ma/4fqmbwa

#Amblyopia is the leading cause of monocular vision loss in children, and early detection & treatment are crucial for the best outcomes. This Special Communication introduces an evidence-derived, web-based amblyopia decision support tool. ja.ma/4b8OJaU

In a patient with classic #Aniridia and negative conventional genetic testing, OGM and lrWGS revealed a small intrachromosomal translocation separating #PAX6 from its regulatory region, resulting in gene haploinsufficiency. ja.ma/4f1fOPJ

For #GeographicAtrophy clinical trials incorporating run-in phases in randomized clinical trials or single-arm designs can improve trial efficiency and decrease sample sizes, exploiting the inherent stability of atrophy enlargement rates. ja.ma/4waCKC5

In a large UK Biobank study, genetic risk scores for #IntraocularPressure were more accurate in older individuals, but accounting for genotype × age interactions did not improve predictive accuracy. ja.ma/4w3UXkH

Following copayment assistance defunding, nAMD patients who switched to bevacizumab had similar 6-month vision & retinal thickness outcomes as those continuing prior therapy, but required shorter injection intervals and faced increased out-of-pocket costs. ja.ma/4uMdQHG

In proliferative #diabetic #retinopathy, brolucizumab was more effective than panretinal laser photocoagulation for preserving visual acuity at 54 weeks and associated with fewer ocular adverse events but increased intraocular inflammation. ja.ma/3SfRDUY

Among #astronauts and bed rest participants, repeat #spaceflight or head-down tilt bed rest did not increase the magnitude of optic disc edema or brain ventricular expansion, with similar structural changes observed after first and second exposures. ja.ma/4xIpeHm

📄 This case report discusses retinal vein occlusion secondary to racemose hemangioma in a woman aged 40 years with sudden painless vision loss in the right eye.

A routine eye scan used in the NICU may help predict developmental delays in very preterm infants, according to new Duke Health research in @jamaophthalmology.bsky.social. The retina may offer a non-invasive “window into the brain”, helping identify risk earlier. More: https://duke.is/c/rw6a

Diagnostic accuracy of a retinal birefringence scanning device compared with a traditional autorefraction device ft. Julius Oatts (@chopresearch.bsky.social), Ha-Neul Yu, Maanasa Indaram, Jocelyn He & Gui-Shuang Ying (Ophthalmology) @jamaophthalmology.bsky.social jamanetwork.com/journals/jam...

Among three leading ophthalmology journals between mid-2024 and late 2025, STROBE guideline adherence was high for core reporting items but suboptimal for missing data, participant flow, and generalizability in ophthalmology observational studies. ja.ma/43C1hDK

Among three leading ophthalmology journals between mid-2024 and late 2025, STROBE guideline adherence was high for core reporting items but suboptimal for missing data, participant flow, and generalizability in recent ophthalmology observational studies. ja.ma/4dZGno4

📄 This case report discusses a diagnosis of central retinal artery occlusion with gradual reperfusion and improvement in the visual acuity after alprostadil treatment in a female patient aged 67 years. ja.ma/4eCllMs

Swept-source #OCTA biomarkers, including choriocapillaris flow deficit and vessel skeleton density, distinguished normal cognition, MCI, and #AlzheimerDisease dementia, suggesting potential for noninvasive cognitive screening. ja.ma/43sRa48

In a patient with dome-shaped macula, acute hypotony after lens implantation led to complete resolution of chronic subretinal fluid sustained for >7 months, suggesting intraocular pressure modulation may influence fluid dynamics. ja.ma/4xfU0XO

Among patients with #diabetes in both SEED and UK Biobank cohorts, metformin use was not associated with reduced risk of age-related macular degeneration compared to other antidiabetic medication or no antidiabetic medication. ja.ma/4fum6rQ

📄 This case report discusses the finding of granular fluorescein flow on fluorescein angiography in a young boy with stage E retinoblastoma. ja.ma/4dUqE9W

Bedside optical coherence tomography imaging at 36 weeks' postmenstrual age in very preterm infants indicated RNFL thickness predicts motor and cognitive outcomes and lowers autism risk at age 2 years. ja.ma/4ocz6Vx

A smartphone-based #AI application enabled population-level self-screening for ocular surface malignancies, achieving specialist-level diagnostic accuracy and identifying rare tumors without enucleation. ja.ma/4x9lEpm

In preterm infants undergoing retinopathy of prematurity screening, noncontact handheld optical coherence tomography caused less behavioral and physiological stress and fewer adverse events than contact fundus photography. ja.ma/4uLdKkv

Six cases of postoperative fungal #Endophthalmitis after #CataractSurgery were linked to Sarocladium kiliense contamination in off-label trypan blue solution, emphasizing the need for sterilization and infection control. ja.ma/4aa31rl

No strong or consistent association was identified between reticular pseudodrusen and #CardiovascularDisease events or mortality in separate analyses from the #AREDS and #AREDS2 clinical trials. ja.ma/4uG4xtq

Six cases of postoperative fungal #Endophthalmitis after #CataractSurgery were linked to Sarocladium kiliense contamination in off-label trypan blue solution, emphasizing the need for sterilization and infection control. ja.ma/4wMpx3a

In a patient with classic #Aniridia and negative conventional genetic testing, OGM and lrWGS revealed a small intrachromosomal translocation separating #PAX6 from its regulatory region, resulting in gene haploinsufficiency. ja.ma/4tR8EBU

A qualitative study found that a voice-based #AI assistant for #Ophthalmology was perceived as empathetic, understandable, and helpful for patient education, but clinicians and patients agreed it could complement human interaction. ja.ma/4nEqQgK

📄 This case report discusses intralenticular stratification in the #cataract of a boy aged 13 years with a history of familial exudative vitreoretinopathy and total retinal detachment. ja.ma/43cOHdL

In a patient with classic #Aniridia and negative conventional genetic testing, OGM and lrWGS revealed a small intrachromosomal translocation separating #PAX6 from its regulatory region, resulting in gene haploinsufficiency. ja.ma/4dtQDUc

For #GeographicAtrophy clinical trials incorporating run-in phases in randomized clinical trials or single-arm designs can improve trial efficiency and decrease sample sizes, exploiting the inherent stability of atrophy enlargement rates. ja.ma/4eVC9ih

📄 This case report discusses a patient with vitiligolike hypopigmentation and eczematous dermatitis associated with topical treatment with atropine and dorzolamide. ja.ma/3RA6ysv

Allison I. Summers, OD, MCR, discusses the Amblyopia Navigator Decision-Support Instrument, a user-friendly decision support tools for diagnosing and managing the most common forms of amblyopia in children, with Neil Bressler, MD. 🎧 Listen now: ja.ma/4n3O2oj

#Amblyopia is the leading cause of monocular vision loss in children, and early detection & treatment are crucial for the best outcomes. This Special Communication introduces an evidence-derived, web-based amblyopia decision support tool. ja.ma/3QW1heJ

📄 This case report discusses a patient with vitiligolike hypopigmentation and eczematous dermatitis associated with topical treatment with atropine and dorzolamide. ja.ma/4cW1uHu

📄 This case report describes the ocular injury incurred after blunt ocular trauma secondary to a fishhook in the left eye of a male child, aged 6 years. jamanetwork.com/journals/jam...

FOXC1 duplications were among the most common monogenic causes of juvenile open-angle glaucoma (JOAG) in two large registries, with high penetrance and variable ocular features. ja.ma/4uGsFMs

FOXC1 duplications were among the most common monogenic causes of juvenile open-angle glaucoma (JOAG) in two large registries, with high penetrance and variable ocular features. ja.ma/4u2aHnJ

#Amblyopia is the leading cause of monocular vision loss in children, and early detection & treatment are crucial for the best outcomes. This Special Communication introduces an evidence-derived, web-based amblyopia decision support tool. jamanetwork.com/journals/jam...

FOXC1 duplications were among the most common monogenic causes of juvenile open-angle glaucoma (JOAG) in two large registries, with high penetrance and variable ocular features. ja.ma/4tfaNXF

In a large UK Biobank study, genetic risk scores for #IntraocularPressure were more accurate in older individuals, but accounting for genotype × age interactions did not improve predictive accuracy. jamanetwork.com/journals/jam...

Distinct preflight factors predicted spaceflight-associated neuro-ocular syndrome (SANS) features in astronauts: myopic refraction and longer axial length for vision changes, and higher weight, smaller head breadth, & mission duration for optic disc edema. ja.ma/4t8Nyym

#UvealMelanoma risk is approximately 31 times higher in individuals with monoallelic germline MBD4 pathogenic variants, supporting broad patient genetic screening for therapeutic and counseling value. ja.ma/4tePrJT

In a large UK Biobank study, genetic risk scores for #IntraocularPressure were more accurate in older individuals, but accounting for genotype × age interactions did not improve predictive accuracy. jamanetwork.com/journals/jam...

This case report discusses hyperacute outer retinal dysfunction in a child with long-term follow-up. 📄Read the full report: ja.ma/3ORhp0r

📄 This case report discusses the development of a corneal bulla during phacoemulsification in a female patient undergoing cataract extraction. ja.ma/3QEOXzo

📃 This case report describes the potential phenotypic features in 2 patients with enhanced S-cone syndrome: rosettelike and whorllike lesions. ja.ma/48e9eSo

In proliferative diabetic retinopathy, brolucizumab was more effective than panretinal laser photocoagulation for preserving visual acuity at 54 weeks and associated with fewer ocular adverse events but increased intraocular inflammation. ja.ma/4eEnCHq

Most ophthalmology subspecialties yield positive financial returns compared to comprehensive training, but gender disparities in compensation persist, and some fellowships never recoup income lost during additional training. ja.ma/41RFo2l

Patients with hearing impairment were less likely to achieve meaningful functional gains in vision rehabilitation, even after adjusting for baseline visual function and covariates. ja.ma/4ePs4TE