Correlation in geographic atrophy enlargement rates between fellow eyes in AREDS2 was modest and variable, with weaker concordance for larger GA or perimeter-adjusted rates. ja.ma/4sa36la

This case report describes a diagnosis of preseptal and orbital inflammation after intravenous infusion of the bisphosphonate zoledronate for osteoporosis in a woman aged 64 years. ja.ma/3NS2i6r

Arachidonic acid and docosahexaenoic acid supplementation reduced the risk of severe #ROP by nearly half in extremely preterm infants, independent of individual risk factors. ja.ma/4cpgSdZ

This case report discusses a diagnosis of conjunctival Kaposi sarcoma in a male patient aged 26 years with a history of advanced HIV infection who presented with a painless red conjunctival nodule. ja.ma/3PuveBZ

Continuing anti–vascular endothelial growth factor injections after acute #Stroke or #MI was not associated with increased risk of death or disability, supporting safety without need for treatment modification. ja.ma/41zlGrS

Tapered cessation of low-concentration atropine for childhood myopia progression resulted in less myopia and axial elongation than abrupt stopping, especially for younger or more myopic children. jamanetwork.com/journals/jam...

This case report describes the diagnosis and treatment of conjunctival papilloma in a patient aged 54 years who presented with a 3-month history of a painless lower left eyelid lesion. ja.ma/3NItK6A

Cataract surgery did not elevate conversion risk to #NeovascularAMD in patients with or without existing #AMD through 2 years of follow-up. ja.ma/47n0t8a

#RetinalConditions affect millions and are primarily managed with anti-VEGF therapies. Neil Bressler, MD, and Alvin Liu, MD, discuss a meta-analysis integrating NHANES, Medicare, and commercial claims data to update US prevalence estimates. ja.ma/4uLq9FA

📃 Case report describes bilateral conjunctival pyogenic granuloma resulting from lazertinibe-amivantamab therapy for metastatic non–small-cell lung cancer. ja.ma/4lYQIDf

In 2025, JAMA Ophthalmology launched “JAMA Eye on AI” and expanded global reach via launching a WeChat account, achieving a Journal Impact Factor of 9.2. Read "JAMA Ophthalmology—The Year in Review, 2025" by Editor in Chief Neil M. Bressler, MD. ja.ma/3NfanSt

#AgeRelatedMacularDegeneration, #DiabeticRetinopathy, #DiabeticMacularEdema, and #RetinalVeinOcclusion rates in the US were substantial in 2022, with prevalence and disparities varying by sex, race and ethnicity, and region. jamanetwork.com/journals/jam...

📄 This case report discusses the development of a corneal bulla during phacoemulsification in a female patient undergoing cataract extraction. ja.ma/4bhbLx7

Patients with hearing impairment were less likely to achieve meaningful functional gains in vision rehabilitation, even after adjusting for baseline visual function and covariates. ja.ma/3NmdcRA

Patients with hearing impairment were less likely to achieve meaningful functional gains in vision rehabilitation, even after adjusting for baseline visual function and covariates. ja.ma/4lxCQ2w

RB1 variant–positive patients with unilateral retinoblastoma diagnosed before 9 months had high bilateral conversion risk, while those diagnosed later or RB1 variant–negative had very low risk. ja.ma/4cCBZeq

Pembrolizumab immunotherapy for bladder cancer may trigger rapid vision loss due to cancer-associated retinopathy. ja.ma/4kEw4HL

Despite guidelines, vancomycin prescribing for bacterial keratitis has increased, while cefazolin use remains low. ja.ma/3OItEf4

This case report discusses a diagnosis of B-cell lymphoma mucosa-associated lymphoid tissue (MALT) in the conjunctiva of a young boy who presented with a painless, enlarging conjunctival mass. ja.ma/40cQQ7O

Structured allergy reclassification and pharmacy collaboration increased intracameral cefuroxime use from 2% to 71% in cataract surgeries for patients with penicillin allergy labels. ja.ma/4lhOazm

A 66-year-old man had nebulomacular corneal opacities, iris atrophy, and corectopia along with coarse facial skin, resorbed digits, anesthetic patches, and healed trophic skin ulcers. What would you do next? ja.ma/4aBvNk4

This case report discusses a unilateral multifocal human T-lymphotropic virus type 1 choroiditis in a male patient presenting with panuveitis of the right eye. ja.ma/4b9myrJ

Structured allergy reclassification and pharmacy collaboration increased intracameral cefuroxime use from 2% to 71% in cataract surgeries for patients with penicillin allergy labels. ja.ma/40gDveQ

Subcutaneous pentosan polysulfate sodium may induce maculopathy at 10-fold lower doses than oral therapy, emphasizing the need for retinal monitoring. ja.ma/4tD47UH

A 42-year-old man had a 1-year history of painless blurred vision and visual field defect in the right eye that had acutely worsened over the past month, and he reported headache and neck stiffness. What would you do next? Take the Clinical Challenge: ja.ma/4lfcHFl

A rapid increase in #FGF21 during the first postnatal week identified preterm infants at higher risk for severe retinopathy of prematurity, suggesting early metabolic stress as a modifiable target. ja.ma/40ileO1

In smear- and culture-negative fungal keratitis, the CRISPR-based rapid identification assay showed good sensitivity and fair specificity vs in vivo confocal microscopy, supporting its use as a rapid adjunct diagnostic. ja.ma/3OPeSU5

Structured allergy reclassification and pharmacy collaboration increased intracameral cefuroxime use from 2% to 71% in cataract surgeries for patients with penicillin allergy labels. ja.ma/4ldhmaZ

This case report discusses how long-read sequencing enables phasing and complements clinical testing to provide a complete genetic diagnosis in TYR-associated oculocutaneous #albinism. ja.ma/4rMezYe

Despite using IOP as a continuous risk factor, clinicians are disproportionately more likely to initiate glaucoma treatment at IOP ≥22 mm Hg. ja.ma/4bSSwdO

This case report describes a case of Peters anomaly with central #corneal #neovascularization diagnosed in a female toddler who presented with acute intracorneal #hemorrhage in the right eye. ja.ma/4rI7QPv

A personalized health coaching program improved medication adherence and reduced glaucoma-related distress compared with standard written education among adults with #glaucoma. ja.ma/3OxljLo

Among professional and amateur #pickleball players, reported use of protective eyewear was low, with professionals less likely to use eyewear than amateurs. ja.ma/3P15OeH

In a pediatric case series, most children receiving voretigene neparvovec for RPE65 retinopathy showed improved VEPs, while visual acuity mostly remained unchanged. ja.ma/40cR1Qw

A personalized health coaching program improved medication adherence and reduced glaucoma-related distress compared with standard written education among adults with #glaucoma. ja.ma/4b7rMFs

This case report discusses a diagnosis of reticular epithelial corneal edema in a male patient aged 57 years who presented with a sudden decrease in vision in his right eye, which was receiving treatment with netarsudil for neovascular #glaucoma. ja.ma/4reMEQV

Among professional and amateur #pickleball players, reported use of protective eyewear was low, with professionals less likely to use eyewear than amateurs. ja.ma/4cdllBW

This case report discusses spontaneous intracystic hemorrhage in a conjunctival lymphangiectasia diagnosed in a female patient aged 36 years with a 1-year history of a left eye conjunctival vesicle. ja.ma/4aIQ87e

Female carriers of RPGR variants causing X-linked cone dystrophy present with mild central cone dysfunction, macular changes, and preserved peripheral retina, distinct from rod-cone phenotypes. ja.ma/4cuTugr

A personalized health coaching program improved medication adherence and reduced glaucoma-related distress compared with standard written education among adults with #glaucoma. ja.ma/4ceePL9

This case report discusses hyperacute outer retinal dysfunction in a child with long-term follow-up. 📄Read the full report: ja.ma/4sdKcdD

A cross-sectional study of global retinopathy of prematurity (ROP) burden documented 8.79 million cases of ROP-related visual loss from 1990 to 2021, with the majority occurring in countries with low and low-middle social demographic index (SDI). ja.ma/4aBvGoE

Among professional and amateur #pickleball players, reported use of protective eyewear was low, with professionals less likely to use eyewear than amateurs. ja.ma/4cdMMM2

A vendor-agnostic #deeplearning model identified multiple #MacularDisease categories and provided triage recommendations from 3D optical coherence tomography (OCT) scans, achieving high accuracy for urgent and semi-urgent cases across OCT vendors. ja.ma/3ZPFp5Y

💬 Editorial: The “Eye on AI” series by JAMA Ophthalmology aims to translate complex #AI advances into practical concepts for clinicians, accelerating adoption of safe, effective AI in ophthalmic care. ja.ma/4qCl3Ic

Among professional and amateur #pickleball players, reported use of protective eyewear was low, with professionals less likely to use eyewear than amateurs. ja.ma/4rz8yyj

A personalized health coaching program improved medication adherence and reduced glaucoma-related distress compared with standard written education among adults with #glaucoma. ja.ma/4aQs3vk

Multicolor imaging revealed a novel epiretinal hyperproliferative complex in a patient with persistent visual symptoms post-cataract surgery. ja.ma/4aB5drg

Factors such as Step 2 scores ≥260, Alpha Omega Alpha status, and attending a top 10 medical school increased ophthalmology match odds, supporting programs targeting pathway inclusion. ja.ma/4bYcqEf

Among adults with polypoidal choroidal vasculopathy, visual and anatomical outcomes at 48 weeks were comparable between aflibercept 8 mg every 12 or 16 weeks and aflibercept 2 mg every 8 weeks. ja.ma/4axPN8B