In this cohort study of repeat long-duration spaceflight missions, previous SANS diagnosis and optic disc edema severity reliably predicted recurrence in individual astronauts. ja.ma/48kd4IE

On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new @who.int guideline concerning #GLP-1 therapy and adults with #obesity. Register for the webinar: ja.ma/48oHolo

Descemet membrane endothelial keratoplasty (#DMEK) demonstrated superior contrast sensitivity compared with ultra-thin Descemet stripping automated endothelial keratoplasty (#DSAEK). ja.ma/3MoVRX9

The 23-item Vitreous Floaters Functional Questionnaire had high test-retest reliability and correlated with vitreous structure and visual function. ja.ma/49GVIIn

In patients with molecularly confirmed USH1C-associated retinopathy, longitudinal assessment demonstrates slow progression of vision loss and structural change into middle adulthood, with preservation of central vision in some cases. ja.ma/3Mn83Ys

Up to 82% of UK patients with geographic atrophy would accept intravitreal complement inhibitor therapy if it offered vision benefits, with perceived effectiveness and ability to attend clinic visits driving acceptability. ja.ma/43V9hQS

On December 1 at 10 AM ET, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new WHO guideline concerning #GLP-1 therapy and adults with #obesity. Register for the webinar: ja.ma/4adNgAr

In a small case series, topical compounded imiquimod 5% ointment was associated with complete or partial resolution of conjunctival MIS, OSSN, and PAM in five patients, with no serious safety events observed. ja.ma/4pwroES

An 11-day-old boy was referred for evaluation of right eye leukocoria and was diagnosed with persistent fetal vasculature. Fundus photographs revealed perfluoro-n-octane bubbles in the inferior retina. What would you do next? ja.ma/4836CXO

Use of atropine for cycloplegia in preschool children was associated with less myopic refraction compared with cyclopentolate and may potentially avoid overestimation of premyopia prevalence. ja.ma/48jlJev

Among patients with newly diagnosed #glaucoma, lower wealth was associated with decreased odds of achieving the minimum reduction in intraocular pressure recommended by national guidelines on quality of care. ja.ma/4rglEAT

The incidence of acute angle closure following pharmacologic pupillary dilation in a large teleretinal diabetic retinopathy screening program was low. ja.ma/4oYolFM

This case report describes the discovery of Stargardt disease in an individual 4 years after having been included as a healthy control in an adaptive optics imaging study. ja.ma/4o1xM5T

In a cohort study of International Space Station crewmembers, early increases in total retinal thickness measured by optical coherence tomography (#OCT) at 30 days predicted progression of #OpticDiscEdema up to 6 months into spaceflight. ja.ma/49pyo1J

Among Singaporean older adults, the contemporary prevalence of undiagnosed age-related #MacularDegeneration and #DiabeticRetinopathy approached 90%, while undiagnosed #Cataracts and #Glaucoma affected about 40% and 48%, respectively. ja.ma/4rf4Vhu

This case report describes a large choroidal excavation and outer retinal atrophy in an otherwise healthy man aged 29 years who presented with bilateral gradually worsening vision since childhood. ja.ma/49Y0DET

This case report documents vision outcomes in a 15-year-old boy following orbital cellulitis and subperiosteal abscess. ja.ma/3K5QY4B

Between 2014 and 2024, the number of ophthalmology practice locations increased, leading to improved access and reduced average driving distances from isolated optometry offices to ophthalmologists. ja.ma/47Zdxjk

Interview with Darren Shu Jeng Ting, PhD author of Performance of Foundation Models Vs Doctors in Textual and Multimodal Ophthalmological Questions. Hosted by Neil Bressler, MD. ja.ma/47y9lbv

Manual marking-assisted capsulorhexis achieves similar accuracy and stability as digital guidance in cataract surgery. ja.ma/4ozdRMO

Claude 3.5 Sonnet and GPT-4o outperform previous models and trainees in answering textual ophthalmology questions, but multimodal capabilities remain insufficient for clinical application. ja.ma/3LXwueQ

Nearly 7% of US residents live over two hours from neuro-ophthalmology care, with the greatest gaps in rural and socioeconomically disadvantaged areas. ja.ma/3JMLr2O

A previously healthy 31-year-old woman presents with acute unilateral anterior uveitis with hypopyon and an iris lesion and systemic symptoms, including headache, fatigue, and fever. What would you do next? ja.ma/3LuhvZW

Apraclonidine eye drops may cause severe CNS and respiratory depression in infants and young children. ja.ma/3XeZn8O

Five-year outcomes after pediatric traumatic cataract surgery showed low rates of glaucoma but frequent need for additional surgery and continued risk of vision loss. ja.ma/4qJKvgl

Rigid gas-permeable contact lenses yielded superior visual outcomes compared to glasses in children following primary congenital #glaucoma surgery. ja.ma/43RkpOn

Distinctive HR-OCT features in pseudoxanthoma elasticum highlight Bruch membrane calcification and provide a potential early marker for progression and treatment response. ja.ma/495IdSm

Multifocal geographic atrophy is associated with faster progression and visual decline; risk factors for new lesion formation overlap only partially with those for initial GA occurrence. ja.ma/4qIlces

This case report describes the grading and effects of myopic traction maculopathy in eyes with high myopia. ja.ma/4nrYzs1

This case report discusses a diagnosis of posterior lenticonus with intralenticular cracks found during a school vision screening in a girl aged 8 years referred for decreased visual acuity in the left eye. ja.ma/4owwGzG

This case report discusses a diagnosis of medication-associated maculopathy in a 44-year-old woman receiving exemestane treatment after breast cancer resection. ja.ma/4hv2oeA

Case report: Oral tofacitinib achieved rapid and sustained remission in cases of refractory thyroid eye disease, targeting proinflammatory cytokine pathways implicated in orbital fibroblast activation. ja.ma/4oxIAJI

Interview with Noemi Lois, MD, PhD, author of Retinal Sensitivity and Retinal Perfusion in Diabetic Retinopathy. Hosted by Neil Bressler, MD. ja.ma/4ogBc5W

Retinal capillary nonperfusion produces greater sensitivity deficits in people with #diabetic retinopathy, but one-third of perfused areas also show reduced function. ja.ma/4qthvJz

RCT: Low-level red-light therapy for #myopia control slows axial elongation and refractive change, with some participants showing temporary retinal changes on OCT which resolved without affecting vision. ja.ma/3Wm4Dam

Smooth pursuit eye movement velocity in Division I American football players was not affected by repetitive head impacts during a single season. ja.ma/3JewPsN

While the incidence of ocular complications was higher in myopic children compared to nonmyopic ones, atropine use for #myopia control was not associated with these risks. ja.ma/4nnK2NH

Advanced multimodal imaging indicates that vision loss in AZOOR initiates at the level of phototransduction within photoreceptor outer segments. ja.ma/4quIYdW

Metformin use is not significantly associated with the development or progression of age-related macular degeneration (AMD), suggesting similar risks of AMD and its progression between those prescribed metformin and those not. ja.ma/3LcoqXj

#GLP-1RA use was associated with reduced risk of developing nonexudative AMD but was not associated with progression to exudative AMD among individuals with nonexudative AMD. ja.ma/47jooo0

Among people with type 2 #diabetes, risk of #retinopathy onset increased with higher HbA1C and frequent nonsevere #hypoglycemia. ja.ma/4nnHUpk

Apixaban, paclitaxel, ibrutinib, and sildenafil use is associated with elevated rates of #maculopathy, with incidence estimates up to 15.7% and dose-dependent risk for some agents. ja.ma/3LnQGGs

DeepSeek-R1 demonstrated superior performance compared to #OpenAI o1 in clinical diagnosis and management across subspecialties, while also reducing operating costs. ja.ma/49cezuA

Patients of Hispanic descent had lower success rates and higher failure rates for initial trabeculectomy with mitomycin C compared to those of European descent, according to this study. ja.ma/3KTDNnD

Deep learning–based analysis of unsegmented optical coherence tomography scans distinguished between different forms of optic nerve atrophy. ja.ma/3WeCGBd

Prescriptions for #GLP1 receptor agonists were associated with a reduced risk of developing uveitis, suggesting potential anti-inflammatory benefits beyond glycemic control. ja.ma/4nXQ49a

An 11-day-old boy was referred for evaluation of right eye leukocoria and was diagnosed with persistent fetal vasculature. Fundus photographs revealed perfluoro-n-octane bubbles in the inferior retina. What would you do next? ja.ma/48xmeDz

Pickleball-related ocular injuries in US emergency departments rose by an estimated 405 cases annually from 2021 through 2024, with most cases affecting adults aged 50 years or older. ja.ma/4oufnj1

A general-domain #LLM (GPT-4) generated high-quality, novel, and readable ophthalmology board-style multiple-choice questions that were comparable to expert-written questions across key domains. ja.ma/4nT4w1U

💬 Invited Commentary: The DEKS trial showed that donor diabetes did not compromise 1-year DMEK graft success or endothelial cell loss, supporting broader use of diabetic donor tissue to help address corneal tissue shortages. #AAO2025 ja.ma/4oqMK6d