A qualitative study found that a voice-based #AI assistant for #Ophthalmology was perceived as empathetic, understandable, and helpful for patient education, but clinicians and patients agreed it could complement human interaction. ja.ma/4nEqQgK

📄 This case report discusses intralenticular stratification in the #cataract of a boy aged 13 years with a history of familial exudative vitreoretinopathy and total retinal detachment. ja.ma/43cOHdL

In a patient with classic #Aniridia and negative conventional genetic testing, OGM and lrWGS revealed a small intrachromosomal translocation separating #PAX6 from its regulatory region, resulting in gene haploinsufficiency. ja.ma/4dtQDUc

For #GeographicAtrophy clinical trials incorporating run-in phases in randomized clinical trials or single-arm designs can improve trial efficiency and decrease sample sizes, exploiting the inherent stability of atrophy enlargement rates. ja.ma/4eVC9ih

📄 This case report discusses a patient with vitiligolike hypopigmentation and eczematous dermatitis associated with topical treatment with atropine and dorzolamide. ja.ma/3RA6ysv

Allison I. Summers, OD, MCR, discusses the Amblyopia Navigator Decision-Support Instrument, a user-friendly decision support tools for diagnosing and managing the most common forms of amblyopia in children, with Neil Bressler, MD. 🎧 Listen now: ja.ma/4n3O2oj

#Amblyopia is the leading cause of monocular vision loss in children, and early detection & treatment are crucial for the best outcomes. This Special Communication introduces an evidence-derived, web-based amblyopia decision support tool. ja.ma/3QW1heJ

📄 This case report discusses a patient with vitiligolike hypopigmentation and eczematous dermatitis associated with topical treatment with atropine and dorzolamide. ja.ma/4cW1uHu

📄 This case report describes the ocular injury incurred after blunt ocular trauma secondary to a fishhook in the left eye of a male child, aged 6 years. jamanetwork.com/journals/jam...

FOXC1 duplications were among the most common monogenic causes of juvenile open-angle glaucoma (JOAG) in two large registries, with high penetrance and variable ocular features. ja.ma/4uGsFMs

FOXC1 duplications were among the most common monogenic causes of juvenile open-angle glaucoma (JOAG) in two large registries, with high penetrance and variable ocular features. ja.ma/4u2aHnJ

#Amblyopia is the leading cause of monocular vision loss in children, and early detection & treatment are crucial for the best outcomes. This Special Communication introduces an evidence-derived, web-based amblyopia decision support tool. jamanetwork.com/journals/jam...

FOXC1 duplications were among the most common monogenic causes of juvenile open-angle glaucoma (JOAG) in two large registries, with high penetrance and variable ocular features. ja.ma/4tfaNXF

In a large UK Biobank study, genetic risk scores for #IntraocularPressure were more accurate in older individuals, but accounting for genotype × age interactions did not improve predictive accuracy. jamanetwork.com/journals/jam...

Distinct preflight factors predicted spaceflight-associated neuro-ocular syndrome (SANS) features in astronauts: myopic refraction and longer axial length for vision changes, and higher weight, smaller head breadth, & mission duration for optic disc edema. ja.ma/4t8Nyym

#UvealMelanoma risk is approximately 31 times higher in individuals with monoallelic germline MBD4 pathogenic variants, supporting broad patient genetic screening for therapeutic and counseling value. ja.ma/4tePrJT

In a large UK Biobank study, genetic risk scores for #IntraocularPressure were more accurate in older individuals, but accounting for genotype × age interactions did not improve predictive accuracy. jamanetwork.com/journals/jam...

This case report discusses hyperacute outer retinal dysfunction in a child with long-term follow-up. 📄Read the full report: ja.ma/3ORhp0r

📄 This case report discusses the development of a corneal bulla during phacoemulsification in a female patient undergoing cataract extraction. ja.ma/3QEOXzo

📃 This case report describes the potential phenotypic features in 2 patients with enhanced S-cone syndrome: rosettelike and whorllike lesions. ja.ma/48e9eSo

In proliferative diabetic retinopathy, brolucizumab was more effective than panretinal laser photocoagulation for preserving visual acuity at 54 weeks and associated with fewer ocular adverse events but increased intraocular inflammation. ja.ma/4eEnCHq

Most ophthalmology subspecialties yield positive financial returns compared to comprehensive training, but gender disparities in compensation persist, and some fellowships never recoup income lost during additional training. ja.ma/41RFo2l

Patients with hearing impairment were less likely to achieve meaningful functional gains in vision rehabilitation, even after adjusting for baseline visual function and covariates. ja.ma/4ePs4TE

📃 This case report discusses a diagnosis of trematode granuloma in a child aged 8 years who presented with a painful red right eye after 2 weeks of river swimming. ja.ma/4sUslbE

RB1 variant–positive patients with unilateral retinoblastoma diagnosed before 9 months had high bilateral conversion risk, while those diagnosed later or RB1 variant–negative had very low risk. ja.ma/4mRKe9F

An 82-year-old man presented with 4 months of fluctuating diagonal binocular diplopia and progressive bilateral ptosis that worsened with fatigue, accompanied by generalized weakness, dysphagia, and reduced grip strength. What would you do next? ja.ma/4twngHy

In smear- and culture-negative fungal keratitis, the CRISPR-based rapid identification assay showed good sensitivity and fair specificity vs in vivo confocal microscopy, supporting its use as a rapid adjunct diagnostic. ja.ma/497ISSf

In proliferative diabetic retinopathy, brolucizumab was more effective than panretinal laser photocoagulation for preserving visual acuity at 54 weeks and associated with fewer ocular adverse events but increased intraocular inflammation. ja.ma/41RZDwP

Structured allergy reclassification and pharmacy collaboration increased intracameral cefuroxime use from 2% to 71% in cataract surgeries for patients with penicillin allergy labels. ja.ma/4tybsEO

Among professional and amateur #pickleball players, reported use of protective eyewear was low, with professionals less likely to use eyewear than amateurs. jamanetwork.com/journals/jam...

A personalized health coaching program improved medication adherence and reduced glaucoma-related distress compared with standard written education among adults with #glaucoma. ja.ma/4vXbHuL

In eyes with graft failure after DSAEK, cultured human corneal endothelial cell injection improved visual acuity, corneal thickness, and cell density over three months without significant complications. ja.ma/4vx42Db

Intravitreal vamikibart was tolerated and associated with improved visual acuity and reduced macular thickness over 12 weeks in a phase 1 trial for uveitic macular edema secondary to noninfectious uveitis. jamanetwork.com/journals/jam...

📃 This case report discusses the use of swept-source optical coherence tomography to evaluate the location and morphology of lens lesions. jamanetwork.com/journals/jam...

Most retracted #Ophthalmology articles continued to be cited after retraction, with 80% receiving postretraction citations and nearly half of all citations occurring after retraction. jamanetwork.com/journals/jam...

Most retracted #Ophthalmology articles continued to be cited after retraction, with 80% receiving postretraction citations and nearly half of all citations occurring after retraction. ja.ma/41orowL

One in five fellow eyes had a double-layer sign, but only 40% of these exhibited #neMNV on OCT-A, indicating DLS is not a reliable surrogate in #AgeRelatedMacularDegeneration ja.ma/4cgZmbK

📃 This case series investigates genotype-phenotype correlations in a cohort of patients with aconitase 2 (ACO2)–linked dominant optic atrophy. ja.ma/4vaLiZM

Intravitreal vamikibart was tolerated and associated with improved visual acuity and reduced macular thickness over 12 weeks in a phase 1 trial for uveitic macular edema secondary to noninfectious uveitis. jamanetwork.com/journals/jam...

🎧 Listen to Tiarnán D. L. Keenan, BM BCh, PhD, discuss their study on the post hoc analysis of the Age-Related Eye Disease Study 2 (AREDS2) with Neil Bressler, MD. edhub.ama-assn.org/jn-learning/...

A 42-year-old man had a 1-year history of painless blurred vision and visual field defect in the right eye that had acutely worsened over the past month, and he reported headache and neck stiffness. What would you do next? Take the Clinical Challenge: ja.ma/47NYSbD

This case report describes a patient with B virus infection with clinical features including severe central nervous system dysfunction and bilateral panuveitis. 📄Read the full report: ja.ma/4vhPtmQ

A 38-year-old woman presented with 3 to 4 months of eye heaviness and mild blurred vision (worse in the left eye), which she described as looking underwater. She denied pain, illness, or trauma. What would you do next? Take the Clinical Challenge: ja.ma/4sVXQTs

A precision risk model integrating vascular severity, gestational age, and postmenstrual age reduced retinopathy of prematurity screening examinations by 28% without missing treatment-requiring disease. ja.ma/41dmRNG

Correlation in geographic atrophy enlargement rates between fellow eyes in AREDS2 was modest and variable, with weaker concordance for larger GA or perimeter-adjusted rates. ja.ma/4sa36la

This case report describes a diagnosis of preseptal and orbital inflammation after intravenous infusion of the bisphosphonate zoledronate for osteoporosis in a woman aged 64 years. ja.ma/3NS2i6r

Arachidonic acid and docosahexaenoic acid supplementation reduced the risk of severe #ROP by nearly half in extremely preterm infants, independent of individual risk factors. ja.ma/4cpgSdZ

This case report discusses a diagnosis of conjunctival Kaposi sarcoma in a male patient aged 26 years with a history of advanced HIV infection who presented with a painless red conjunctival nodule. ja.ma/3PuveBZ

Continuing anti–vascular endothelial growth factor injections after acute #Stroke or #MI was not associated with increased risk of death or disability, supporting safety without need for treatment modification. ja.ma/41zlGrS

Tapered cessation of low-concentration atropine for childhood myopia progression resulted in less myopia and axial elongation than abrupt stopping, especially for younger or more myopic children. jamanetwork.com/journals/jam...