Single-cell analysis integrated with machine learning elucidates the mechanisms of nucleus pulposus cells apoptosis in intervertebral disc degeneration and therapeutic interventions. Read more by Chao Song & coauthors: onlinelibrary.wiley....

Daqian Zhou & coauthors performed an analysis of key sifferential metabolites in intervertebral disc degeneration based on untargeted metabolomics. Learn more in JOR Spine: onlinelibrary.wiley....

There is currently no consensus on the classification of lumbar facet joints based on X-ray imaging. Xiaowen Liu &coauthors developed and evaluated the reliability of a grading system: onlinelibrary.wiley....

What is the significance of the MAPK signaling pathway in the diagnosis and subtype classification of intervertebral disc degeneration? Yong Liu & coauthors investigated this question: onlinelibrary.wiley....

This recent review by Matthew A. R. Trone & coauthors highlights hyperacidity's effects on the intervertebral disc, such as catabolism of disk cells, neoinnervation, altered mechanical signaling, and expression of pro-inflammatory cytokines and ion channels. Learn more: onlinelibrary.wiley....

Failure of spine implants is particularly serious due to the implant location near the spinal cord and nerves. Annette Kienle & coauthors suggest an improved approach to mechanical testing of new devices: onlinelibrary.wiley....

Posterior lumbar interbody fusion is used to treat various spine disorders, but can sometimes result in biomechanical deterioration in adjacent spine segments. Lipeng He & Tingchen Zhu and coauthors used finite element modeling to better understand this problem: onlinelibrary.wiley....

A better understanding of different cell sub-populations present in the adult nucleus pulposus of spinal discs can provide insight into aging and degeneration. Andra-Maria Ionescu & coauthors present their findings in JOR Spine: onlinelibrary.wiley....

Chronic low back pain, a significant global health concern, is often linked to vertebral bone marrow lesions, such as fatty replacement. Wentian Li & coauthors explored relationships between the gut microbiome, serum metabolome, & fatty replacement in chronic low back pain: onlinelibrary.wiley....

Work by Ting-Yuan Tu & coauthors reveals how differences in extracellular matrix, stiffness, and myofibroblast distribution between ventral and dorsal layers unlock new insights into ligamentum flavum hypertrophy pathogenesis: onlinelibrary.wiley....

Yangyang Xu & coauthors present a novel growth rod featuring unidirectional sliding and external regulation capabilities, providing dynamic correction and reducing the risk of infection through a non-invasive lengthening mechanism: onlinelibrary.wiley....

Scoliosis instrumentation diminishes the natural coupling behavior of the spine. Could this explain correction loss and junctional deformity in the long-term? Read more from Christian Liebsch & coauthors: onlinelibrary.wiley....

Aimin Gong, Daniel Yang, and Mengjie Zeng found genetic evidence supporting the causal relationship between arthritis and low back pain, especially highlighting the significant impact of hip osteoarthritis: onlinelibrary.wiley....

Work by Xiang-Yu Li & coauthors, employing multiomics approaches, revealed that the genes associated with lumbar disc degeneration are regulated by DNA methylation and identified genetic variances between gene expression and the gut microbiota: onlinelibrary.wiley....

Can puerarin treat intervertebral disc degeneration by regulating nucleus pulposus cell death? Xiaoqiang Wang & coauthors present their findings in JOR Spine: onlinelibrary.wiley....

The @jorspine.bsky.social welcomes three new Associate Editors: Cheryle Seguin, PhD; Fabio Galbusera, PhD; and Ashish Diwan, MD, PhD. Their #spine expertise supports our aspiration to broaden #preclinical research in the journal. Learn more: bit.ly/4m5yCyT

Explore how inflammatory cytokine Resistin (RETN) influences scoliosis progression - Muradil Mardan & coauthors found significant genetic links using bidirectional Mendelian randomization: onlinelibrary.wiley.... #ScoliosisResearch #Inflammation #Genetics #SpineHealth

Hanlong Xin & coauthors found that asymmetrical ESR1 expression of bilateral paraspinal muscle progenitor cells was correlated with asymmetrical paraspinal muscle size, asymmetrical fatty infiltration, and more severe scoliotic deformity: onlinelibrary.wiley....

Recent work by Jie Yang & coauthors may help with understanding of the issues with unilateral lumbo-pelvic fixation and strategies for postoperative rehabilitation exercises in patients who has unilateral sacrum fracture: onlinelibrary.wiley....

Stone Sima and Ashish Diwan discuss the contemporary clinical perspectives on chronic low back pain in their recent JOR Spine article. Read it here: onlinelibrary.wiley....

Ruxolitinib delays nucleus pulposus cell senescence in rat intervertebral discs. Learn more in this recent JOR Spine article by Honggang Hao et al.: onlinelibrary.wiley....

Shixiao Zhong & coauthors present their results on the clinical efficacy and biomechanical analysis of a novel hollow pedicle screw combined with kyphoplasty for the treatment of Kümmell disease: onlinelibrary.wiley....

A comprehensive review of cell transplantation and platelet-rich plasma therapy for the treatment of disc degeneration-related back and neck pain. A really nice review @jordyschol.bsky.social 👏🏻

Check out Li Li & coauthor's recent paper to learn about the proteomic landscape of extracellular vesicles derived from human intervertebral disc cells: onlinelibrary.wiley....

What are the effects of extracellular matrix‐degrading enzymes polymorphisms on intervertebral disc degeneration? Find out in this systematic review by Di Zhao & coauthors: pmc.ncbi.nlm.nih.gov...

A study of linezolid for intradiscal administration to treat chronic low back pain associated with Modic type 1 changes demonstrates consistent pharmacokinetics enabling selection of a dose regimen to assess efficay. Read more from Shiva S. Tripathi & coauthors: onlinelibrary.wiley....

An antibiotic formulation that can be injected into spinal discs to treat bacterial infection causing chronic low back pain is ready for first in human studies to assess safety and efficacy. Learn more about results from Graham Hagger et al.: onlinelibrary.wiley....

Hong Sun & coauthors investigated targeting nucleus pulposus cell death in the treatment of intervertebral disc degeneration. Learn more in JOR Spine: onlinelibrary.wiley....

Weishi Liang & coauthors performed a finite element analysis of two-level discontinuous cervical hybrid revision surgery strategy to reduce biomechanical responses of adjacent segments. Read more in JOR Spine: onlinelibrary.wiley....

Interested in intervertebral disc degeneration? Check out recent work on the causal relationships between levels of various matrix metalloproteinases and IDD by Lin Sun & coauthors: onlinelibrary.wiley....

Bioreactors have been used to explore how mechanical loading influences cellular behaviour in the intervertebral disc. But do we actually know more about how the disc responds to the loads that would be experienced in space than on Earth? Learn more in JOR Spine: onlinelibrary.wiley....

Recent research by María González-Rodríguez & coauthors from the NEIRID Lab at Santiago University Clinical Hospital unveils, for the first time, the role of ELF3 in intervertebral disc degeneration: onlinelibrary.wiley....

Check out this recent review by Jordy Schol & coauthors, which highlights the clinical significant differences obtainable through cell and PRP injections against #backpain: onlinelibrary.wiley....

Maryam Nikpasand & coauthors demonstrate and evaluate a method of automated magnetic resonance imaging-based grading of the lumbar intervertebral disc and facet joints in JOR Spine: onlinelibrary.wiley....

Kuibo Zhang, Hua Wang, & coauthors show that melatonin attenuates degenerative disc degression by downregulating DLX5 via the TGF/Smad2/3 pathway in nucleus pulposus cells: onlinelibrary.wiley....

Intervertebral disc degeneration is an age-related orthopedic degenerative disease characterized by recurrent episodes of lower back pain, the pathogenesis of which is not fully understood. This study by Daqian Zhou & coauthors aimed to identify key biomarkers and causes: onlinelibrary.wiley....

A recent study by Chu Tao & coauthors demonstrates a critical role of the Tnf-α/Tnfr signaling in promoting age- and injury-induced intervertebral disc disease in mice, highlighting a potential prevention/treatment pathway: onlinelibrary.wiley....

Khaled Aboushaala & coauthors found that gut microbiome dysbiosis is associated with lumbar degenerative spondylolisthesis in symptomatic patients: onlinelibrary.wiley.... @dinosamartzis.bsky.social

Check out 'Exploring causal correlations between inflammatory cytokines and intervertebral disc degeneration: A Mendelian randomization', by Tao Xu, Guangzi Chen, Jian Li, and Yingchi Zhang in JOR Spine: onlinelibrary.wiley....

Check out this recent review by Jordy Schol & coauthors, which highlights the clinical significant differences obtainable through cell and PRP injections against #backpain: onlinelibrary.wiley....

Maryam Nikpasand & coauthors demonstrate and evaluate a method of automated magnetic resonance imaging-based grading of the lumbar intervertebral disc and facet joints in JOR Spine: onlinelibrary.wiley....

Did you know that silibinin promotes healing in spinal cord injury through anti-ferroptotic mechanisms? Learn more in this recent JOR Spine article by Arman Vahabi & coauthors: onlinelibrary.wiley....

Recent work by Zhongyuan He & coauthors unveils a validated mouse model of chronic spinal cord compression, mimicking ossification of the posterior longitudinal ligament in humans: onlinelibrary.wiley.... #SpinalCordResearch #OPLL #MouseModel

Hypertrophy of the ligamentum flavum is a common chronic spinal condition that affects middle-aged and older adults. However, the molecular pathways behind this disease are not well understood. Fei Liu & coauthors used bioinformatics to identify crucial biological markers: onlinelibrary.wiley....

Tissue-engineered intervertebral discs could improve treatment of severe disc disease/injury. Alikhan B. Fidai & coauthors evaluated a flexible support material & found that it maintains disc height and supports hydrated tissue engineered intervertebral discs formation: onlinelibrary.wiley....

Magnetic resonance imaging (#MRI) noninvasively quantifies disc structure but requires segmentation that is both time intensive and susceptible to human error. Milad I. Markhali & coauthors created a method for automatic slice-wise segmentation of 3D disc volumes: onlinelibrary.wiley....

For those interested in the latest spine research -- increased plasma levels of MMP3 may signify an increased risk of intervertebral disc disease, as published in @jorspine.bsky.social #ORSSMC @orssociety.bsky.social Link: buff.ly/N3HLFe6

Check out 'Exploring causal correlations between inflammatory cytokines and intervertebral disc degeneration: A Mendelian randomization', by Tao Xu, Guangzi Chen, Jian Li, and Yingchi Zhang in JOR Spine: onlinelibrary.wiley....

Did you know that silibinin promotes healing in spinal cord injury through anti-ferroptotic mechanisms? Learn more in this recent JOR Spine article by Arman Vahabi & coauthors: onlinelibrary.wiley....

Recent work by Zhongyuan He & coauthors unveils a validated mouse model of chronic spinal cord compression, mimicking ossification of the posterior longitudinal ligament in humans: onlinelibrary.wiley.... #SpinalCordResearch #OPLL #MouseModel