Mike Bottery
@mbottery.bsky.social
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Microbial Evolution - AMR - University of Manchester
reposted by
Mike Bottery
Natalie Bennett
7 days ago
Currently hosting event on antifungals in medicine and agriculture, focusing on
#AntiMicrobialResistance
#AMR
. With 6.5 million invasive infections globally each year, and 3.8 million deaths attributable to them. Area of fast-rising concern!
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Very proud of Ed's first conference talk at
#BSMM2025
did great despite the technical hiccups!!
15 days ago
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Mike Bottery
Bertuzzi Lab
3 months ago
Interested in working on Mucorales adaptation? Thanks to new funding from
@wellcometrust.bsky.social
, we will have two postdoc and a technician positions advertised very soon! if interested, please get in touch for more information.
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Thrilled to announce I've been awarded a
@wellcometrust.bsky.social
Career Development Award at
@fbmh-uom.bsky.social
, University of Manchester! My research will investigate the remarkable adaptability of Aspergillus fumigatus, a deadly fungal pathogen, to help combat drug resistance.
3 months ago
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Mike Bottery
UK Health Security Agency
4 months ago
The MHRA today released new guidance for
#Phage
therapy in the UK. This will provide direction for scientists and researchers working to make this treatment a reality for patients. 🔬 🧪 🔗
www.gov.uk/government/n...
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reposted by
Mike Bottery
Michael Brockhurst
5 months ago
New preprint with nice detective work by PhD student Khadija Hanga: gain of pOXA MDR plasmid is facilitated by chromosomal mutations affecting OmpF which act synergistically with the plasmid’s carbapenamase to give high level resistance. Led by
@mbottery.bsky.social
www.biorxiv.org/content/10.1...
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Chromosomal resistance mutations facilitate acquisition of multidrug-resistance plasmids in Escherichia coli
Bacteria can gain multiple resistance mechanisms in a single step by the acquisition of multidrug-resistance (MDR) plasmids, but it is unclear how antibiotic selection during the acquisition of MDR pl...
https://www.biorxiv.org/content/10.1101/2025.04.15.648949v1
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@wellcometrust.bsky.social
Thanks for organizing the ERC meeting. I found the research culture activity really helpful, so many great thought-provoking ideas
6 months ago
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Beautiful day to get out of the office and do some fieldwork! Soil samples + 🍄
#failsafe
#mycology
@normanvanrhijn.bsky.social
9 months ago
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New in Nature Comms, we show that azole-resistant Aspergillus fumigatus are more likely to evolve resistance to new antifungals due to variants in their DNA mismatch repair system
rdcu.be/d3Iyc
@natureportfolio.bsky.social
#microsky
#fungi
#amr
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Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance
Nature Communications - Here, Bottery et al show that resistance to next generation antifungals is more likely to occur within azole resistant Aspergillus fumigatus due to the close linkage between...
https://rdcu.be/d3Iyc
9 months ago
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reposted by
Mike Bottery
Michael Brockhurst
10 months ago
In case you missed it:
@matthewjshepherd.bsky.social
surveyed the clinical literature to reveal how
#AMR
evolves within patients, why eco/evo mechanisms vary among infections, & what we can do better to improve treatments
www.nature.com/articles/s41...
#MicroSky
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Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance - Nature Reviews Microbiology
In this Review, Shepherd, Brockhurst and colleagues explore the clinical evidence in support of four major ecological and evolutionary mechanisms of within-patient antimicrobial resistance emergence i...
https://www.nature.com/articles/s41579-024-01041-1
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It was great fun to be part of this project! Super cool to see Rock-Paper-Scissors dynamics in real microbial populations
add a skeleton here at some point
10 months ago
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PhD studentship alert! Fully funded, co-supervised with
@rokkrasovec.bsky.social
and Prof Mike Bromley, University of Manchester Exploring routes of horizontal gene transfer in pathogenic fungi Exciting project, will be a bunch of fun! Come & join us 🔬
www.findaphd.com/phds/project...
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https://www.findaphd.com/phds/project/bicentenary-tracking-horizontal-gene-transfer-and-the-spread-of-antimicrobial-resistance-in-pathogenic-fungi/?p178981
10 months ago
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reposted by
Mike Bottery
Chris Knight
10 months ago
Soil microbiomes show consistent and predictable responses to extreme events We’re out in Nature !!
doi.org/ntzk
Very exciting for my first bluesky post! – it’s been a long haul by an excellent team from across Europe, led by
@frantecol.bsky.social
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Soil microbiomes show consistent and predictable responses to extreme events - Nature
Soils from 30 grasslands across Europe were subjected to 4 contrasting extreme climatic events under drought, flood, freezing and heat conditions, with the results suggesting that soil microbiomes fro...
https://doi.org/ntzk
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Fungal Genetics Stock Centre, there's something fishy going on here...
10 months ago
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It was a pleasure to have the opportunity to present our work!
add a skeleton here at some point
10 months ago
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Excited to be giving a talk this afternoon on the risk of AMR evolution in fungal pathogens
@newcastleuni.bsky.social
#WAAW
#AMR
10 months ago
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