Another truly amazing work by the Capellini lab

Denisovans or their close relatives identified in the fossil record using a gene regulatory phenotyping method. Now out: www.pnas.org/doi/10.1073/...

🧵 Excited to share a new preprint from our lab looking into signals of disease-burden in aDNA (doi.org/10.1101/2025...)! It has long been speculated that transition to sedentary, agricultural and urbanized lifestyle increases disease burden, but can we see this in aDNA?

Given two genomes, can you tell who’s taller or more prone to a disease? How confident can you be? A fresh take on phenotypic inference, now out: rdcu.be/exW4f See thread🧵👇:

6 years ago, we predicted what Denisovans probably looked like. Since then, every new Denisovan specimen💀 - Harbin, Penghu, Xiahe - matched it beautifully. ☑️ Xiahe: 4/4 features match the profile ☑️ Penghu: 5/6 ☑️ and now: Harbin with 16/18! See 🧵 pubmed.ncbi.nlm.nih.gov/31539495/

We showed it first: www.biorxiv.org/content/10.1...

Last year, we posted a preprint providing the first genetic evidence that the Harbin skull likely belonged to a Denisovan: www.biorxiv.org/content/10.1... Today, DNA evidence provided the final proof: www-sciencedirect-com.ezproxy.weizmann.ac.il/science/arti...

Super exciting to see the Penghu jaw confirmed as Denisovan— its features line up beautifully with what we predicted Denisovan mandibles to look like! More in the thread 🧵 pubmed.ncbi.nlm.nih.gov/31539495/

Fascinating, really thought-provoking work by Trevor Cousins, @aylwyn-scally.bsky.social and Richard Durbin, now out in @naturegenet.bsky.social 🧪🧬 Deep ancestral structure shared by all modern humans www.nature.com/articles/s41...

Interested in discovering the genetic changes that made us human? Our lab is looking for students and postdocs! 👩‍🔬👨‍🔬 gokhmanlab.com please RT!