multiple group members are already in Athens for the #elixireurope INTOXICOM workshop and will join the EUROTOX (https://www.eurotox2025.com/) meeting next week #eurotox2025 #elixirtoxicology

On Thursday January 15th 2026 at 16:00 CET, Toni Vallbona Garcia will defend his thesis with the title: “Exploring Mitochondrial Dysfunction in Glaucoma Using Blood Biomarkers” (more details later) #mitochondria #glaucoma

We are the Department of Translational Genomics of Maastricht University, a multidisciplinary team of (cell) biologists, chemists, geneticists, toxicologists and bioinformaticians is working in close collaboration to establish the biological impact of exposures to potentially toxic compounds and […]

#introduction #maastricht We are the new Maastricht University Department of Translational Genomics (just turned 1 years old!), and we also have a #bluesky account You can follow us at https://bsky.app/profile/tgx-um.social.edu.nl.ap.brid.gy to get updates, such as new journal articles

new paper: "Unveiling Cell-Type-Specific Immune Reactions in Human Blood Following Varied Fruit and Vegetable Blends Interventions" https://doi.org/10.1002/mnfr.70238 "DEGs and pathway analyses showed that some blends affected DNA repair in B cells, NF-kappa B […] [Original post on social.edu.nl]

new paper: "Employing human intestinal organoids as advanced in vitro models for mechanistic studies on dietary ingredients" https://doi.org/10.1080/10408398.2025.2550515 'This review provides a framework for utilizing intestinal organoids to study dietary […] [Original post on social.edu.nl]

new paper: "The role of DNA repair deficiency in lipid accumulation: A proof-of-concept study" https://doi.org/10.1016/j.dnarep.2025.103880 "Upon exposure to a mixture of oleic and palmitic acid, DNA damage and mitochondrial copy number were only altered in […] [Original post on social.edu.nl]

new paper: "Immunomodulation of the Breast Cancer Microenvironment by Tumor-Derived Exosomes: Implications for Immunotherapy" https://doi.org/10.1080/07357907.2025.2529878 "Notably, PD-L1 appears to be more enriched on exosomes than on tumor cell surfaces, underscoring the pivotal role of BEXs […]

new paper: "The MiBlend Randomized Trial: Investigating Genetic Polymorphisms in Personalized Responses to Fruit and Vegetable Interventions for Chronic Disease Prevention" https://doi.org/10.3390/antiox14070828 "XRCC1 wildtype carriers were more protected […] [Original post on social.edu.nl]

new paper: "The FAIR AOP roadmap for 2025: Advancing findability, accessibility, interoperability, and re-usability of adverse outcome pathways" https://doi.org/10.1016/j.comtox.2025.100368 "Herein current efforts in addressing the FAIRification of AOP […] [Original post on social.edu.nl]

new paper: "Machine learning classification of steatogenic compounds using toxicogenomics profiles" https://doi.org/10.1016/j.tox.2025.154237 "Enrichment analyses revealed strong associations with lipid metabolism, mitochondrial function, insulin signalling […] [Original post on social.edu.nl]

new paper: "MCT8 deficiency in females" https://doi.org/10.1210/clinem/dgaf311 "Female patients with heterozygous pathogenic variants in SLC16A2 and skewed X-chromosome inactivation may present variable neuro(psycho)logical, behavioural and thyroid function […] [Original post on social.edu.nl]

new paper: "The miRNA-based liquid biopsies for environmental health risk assessment: Insights into arsenic-induced hepatotoxicity and systemic health impacts" https://doi.org/10.1016/j.scitotenv.2025.179825 "Our findings suggest that circulating miRNAs offer […] [Original post on social.edu.nl]

new paper: "Identifying a Novel Causal FAM83H Variant for Autosomal Dominant Amelogenesis Imperfecta Using Exome-Sequencing" "A novel pathogenic, protein-truncating variant was detected in FAM83H, a gene with similar truncating variants known to be associated with ADHCAI."

new paper: "The Role of Genetic Variation in Modulating the Effects of Blended Fruits and Vegetables Versus Fruit- and Vegetable-Coated Food Products on Antioxidant Capacity, DNA Protection, and Vascular Health: A Randomized Controlled Trial" […] [Original post on social.edu.nl]

new paper: "Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice" https://doi.org/10.1186/s12933-025-02823-4 'In an animal model of T1D, GLO1 overexpression attenuates arterial stiffening at the underlying material levels, by […] [Original post on social.edu.nl]

new paper: "The Virtual Human Platform for Safety Assessment (VHP4Safety) project: Next generation chemical safety assessment based on human data" https://doi.org/10.14573/altex.2407211 "The goal of this article is to introduce the project and its […] [Original post on social.edu.nl]

new paper: "Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity" https://doi.org/10.1002/em.22645 "Transcriptomic biomarkers for genotoxicity can be used in Weight of […] [Original post on social.edu.nl]

We are the Department of Translational Genomics of Maastricht University, a multidisciplinary team of (cell) biologists, chemists, geneticists, toxicologists and bioinformaticians is working in close collaboration to establish the biological impact of exposures to potentially toxic compounds and […]

new paper: "Intra-arterial transplantation of autologous mesoangioblasts in m.3243A>G mutation carriers is safe - first phase I/II human clinical study" https://doi.org/10.1016/j.ymthe.2025.07.005 "This first-in-human study demonstrates that intra-arterial […] [Original post on social.edu.nl]

new paper: "E171-induced toxicity in human iPSC-derived colon organoids: Effects on cell viability, ROS generation, DNA damage, and gene expression changes" https://doi.org/10.1016/j.tiv.2025.106105 "Food-grade titanium dioxide (E171) is a widely used food […] [Original post on social.edu.nl]

July 2025 WikiPathways release: 531 edits by 15 contributors and 2 new pathways. https://data.wikipathways.org/ #openscience #biology #RareDisease

new paper: "The MiBlend Randomized Trial: Investigating Genetic Polymorphisms in Personalized Responses to Fruit and Vegetable Interventions for Chronic Disease Prevention" https://doi.org/10.3390/antiox14070828 "The MiBlend Study investigated the effect of […] [Original post on social.edu.nl]

hi @jmillanacosta !

hi @Tooba!

In 2 weeks from now, Ammar Ammar will defend his PhD thesis on "Enhancing the Interoperability and Reusability of Nanosafety Data" at Maastricht University. See also https://scholar.google.com/citations?user=8ZmXyZcAAAAJ&hl=en&inst=13291755310766122872&oi=ao […] [Original post on social.edu.nl]

new paper: "Integrative analysis of 115 transcriptomic studies decodes the molecular landscape of neurodevelopmental disorders" https://doi.org/10.1038/s42003-025-08330-2 "[..] transcriptomic studies of neurodevelopmental disorders (NDDs) often face limited […] [Original post on social.edu.nl]

Javi Millán Acosta's #elixireurope BioHackathon Europe proposal "A shape-driven visual interface to integrate heterogeneous biomedical databases into knowledge graphs" has been approved https://biohackathon-europe.org/projects/

Ammar Ammar will defend his PhD research "Enhancing the Interoperability and Reuseability of NanoSafety Data: A Foundation Towards Deeper Insights and Intelligent Applications" at 10:00 am on Wednesday July 2. Details and link to live stream will follow asap

Nicolaj Sebastian Bischoff will defend his PhD research at 13:00 today. Details and link to live stream here: https://www.maastrichtuniversity.nl/events/phd-defence-nicolaj-sebastian-bischoff

new report: "BioHackEU24 report: Expanding FAIR database integration through elucidation and transformation of underlying graph schemas" https://doi.org/10.37044/osf.io/ptmg5_v1 "we launched the BioDataFuse (BDF) project, which applies a modular framework to harmonize and integratedata from […]

new paper: "Investigating the role of Vitamin D and its targeted gene-pathway interactions involved in cardiometabolic health" https://doi.org/10.25259/OA04_8774 […] [Original post on social.edu.nl]

@bioconductor 3.21 is out, including BridgeDbR 2.18: https://bioconductor.org/packages/release/bioc/html/BridgeDbR.html Includes BridgeDb 3.0.28, and session info and CiTO annotation in the vignette. See https://genomic.social/@bioconductor/114349555185162646 for the general announcement

📣 Workshop | How can knowledge graphs inform us on the complex networks involved in rare diseases? Join us for the Rare Disease Maps Workshop - a two-day online event organised by hashtag#ERDERA that will dive into the current approaches for researching hashtag#RareDisease networks to elucidate […]

new report: "BioHackEU24 report: Integrating Bioconductor packages with the ELIXIR Research Software Ecosystem using EDAM" https://doi.org/10.37044/osf.io/dsgnw_v1 "This project seeks to enhance the ELIXIR Research Software Ecosystem (RSEc) by increasing the [FAIR principles] [..]. By aligning […]

new report: "SKIG Report 2023-2024 - 2023-2024 Report of the Society for the Advancement of AOPs Knowledgebase Interest Group" https://doi.org/10.2760/7749010 "The Society for the Advancement of AOPs Knowledgebase Interest Group (SKIG) is a vibrant assembly of more than 40 international experts […]

Do you want to follow our new publications, then you can use this RSS feed powered by PubMed: https://pubmed.ncbi.nlm.nih.gov/rss/search/1b1xtujbjiHUeSJKTixNvrqI9fygPElaIAi4FhgUvaTxKySYpN/?limit=10&utm_campaign=pubmed-2&fc=20250318114006

new paper: "Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines" https://doi.org/10.1002/em.70004 "Here, we describe the findings of this workshop's subgroup that conducted a systematized review and analysis of in vitro transcriptomic biomarkers for […]

new paper: "Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases" https://www.nature.com/articles/s41588-024-02072-3 https://doi.org/10.1038/s41588-024-02072-3 "This [..] meta-analysis of genome-wide association studies […]

new paper: "Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration" https://doi.org/10.1038/s41467-025-56628-w "enabled us to: (i) identify the genetic aetiology of […] [Original post on social.edu.nl]

new paper: "Genetic and reproductive strategies to prevent mitochondrial diseases" https://doi.org/10.1093/humupd/dmaf004 "Mitochondrial DNA (mtDNA) diseases pose unique challenges for genetic counselling and require tailored approaches to address recurrence […] [Original post on social.edu.nl]

new report/preprint: "BioHackEU24 report: @ORCID_Org and @ResearchOrgs identifiers in BioHackrXiv reports" https://doi.org/10.37044/osf.io/p9u42_v1 "As part of the BioHackathon Europe 2024, we here report on two improvements of theplatform: visualization of the ORCID identifiers in the […]

new Enxembl 111-based gene/protein identifier mapping files are available: https://data.bridgedb.org/gene_database/ (thx to Tooba Abbassi-Daloii, https://github.com/tabbassidaloii)

new paper: "Food-grade titanium dioxide exposure between age groups and in global regions: a systematic review and meta-analysis" https://doi.org/10.1080/10408398.2025.2467823 "Despite its ban in food within the European Union (EU), TiO₂ remains prevalent globally amidst safety debates. This […]

@jerven et al. at @SIB created an exciting platform for sharing SPARQL queries, and I wrote some extension to fit our @tgx_um needs (e.g. author, license, and now citation support). All minimal, but every step counts: https://github.com/BiGCAT-UM/sparql-examples-utils/releases Our first draft […]

Prof. Bert Smeets receives NWO ENW Open Competition XS funding to explore mRNA therapy for LAMA2 Muscular Dystrophy: https://www.maastrichtuniversity.nl/news/dutch-research-council-rewards-three-maastricht-research-proposals #funding #musculardystrophy

new paper: "Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression" https://doi.org/10.1186/s13023-024-03526-x "An interesting finding is that the antigen processing and presentation subnetwork links the […] [Original post on social.edu.nl]