Alejandro (@amendezar.bsky.social)

Why is it so difficult to get drugs where they need to go? 🤔 🧪 This perspective summarizes the challenge of estimating membrane permeability from computer models, lab assays, and animal studies. And it provides guidelines to reconcile the results of the various methods. pubs.acs.org/doi/10.1021/...

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Permeability Benchmarking: Guidelines for Comparing in Silico, in Vitro, and in Vivo Measurements Permeability is a measure of the degree to which cells can transport molecules across biological barriers. Units of permeability are distance per unit time (typically cm/s), where accurate measurement... https://pubs.acs.org/doi/10.1021/acs.jcim.4c01815