New ICAL paper in J. Neurosci! Microglia support endocannabinoid-dependent LTP and episodic memory. Microglia depletion disrupted LTP and memory in mice—effects reversed by enhancing 2-AG signaling. 📄 Chavez et al., 2025 🔗 www.jneurosci.org/content/45/2...

New commentary from ICAL Director Dr. Daniele Piomelli in JPET: “Liking isn’t enough: You got to want it.” As cannabis moves toward Schedule III, Piomelli explores the neurobiology of motivation, abuse liability, and what drives use beyond enjoyment. 🔗 jpet.aspetjournals.org/article/S002...

🧠 THC researchers: Get free adolescent THC brain & organ tissue from UCI ICAL Tissue Bank! No DEA license needed, shipping covered. Limited supply—first-come, first-served! 🌱🔬 📩 DM for info IG: @uci_cannabis | X: @ucicannabis REQUEST HERE: cannabis.uci.edu/ical/tissueb... #CannabisResearch #THC

In case you missed it from ICAL: New publication! Protocol for administering Δ9-THC in adolescent & adult mice, showing effects on catalepsy, locomotion, and pain — with safe, legal handling tips. 🔬💊 Link here: app.jove.com/t/68358/admi...

🎙️ New Science at the Source! Dr. Hilary Marusak + Rodrigo M. Klein, PhD (UC Irvine) on how THC impacts the developing brain. 🧠 Resilience & risk 👩🔬 Microglia & endocannabinoid system 🌍 Context & cannabis use 👉 Watch: www.youtube.com/watch?v=oap6...

📢 Cannabis researchers: UCI ICAL Tissue Bank 🧠🫀 Brain & organs from THC/vehicle-treated mice/rats, prepped for molecular studies. FREE, shipping included, no DEA needed. ⚠️ First-come, first-served! cannabis.uci.edu/ical/tissueb...

🚨 New Science at the Source! Dr. Hilary Marusak talks with Dr. Christine Gall (UC Irvine) on how adolescent THC impacts memory, sex differences, and brain health. 🎥 youtu.be/iBdVUbXZNOA #THC #AdolescentBrain #Memory #ScienceAtTheSource

🚨 Still thinking about this convo with Maricela Martinez. What if the key to understanding addiction risk lies in the brain’s immune cells? Episode 6 of Science at the Source dives into microglia, adolescence, and how early drug exposure may prime the brain. 🎥 youtu.be/RO_g9KTaMCA #Microglia #THC

🚨 Save the Date! 🚨 The MACRC 2025 Conference — the first official ICRS Chapter meeting 🍃 📅 Nov 14–16, 2025 | 📍 Kitty Hawk, NC Abstracts & registration open (early bird thru Sept 21)! 👉 www.m-acrc.org #CannabinoidResearch #MACRC2025 #ICRS

🚨 Rewind to Science at the Source Ep. 5 Dr. Steve Mahler breaks down the neuroscience of craving, THC, and motivation—and what it means for cannabis use and addiction treatment. Still thinking about this one. 🎥 www.youtube.com/watch?v=9ImB... IG → @uci_cannabis #CannabisResearch #MotivationAndReward

🚨 Cannabis researchers: Need THC-exposed brain or organ samples? 🧠🫀 The UCI ICAL Tissue Bank offers FREE tissues (U.S. & abroad), no DEA license needed. Brain tissue = high demand—act fast! 📩 🔗 cannabis.uci.edu/ical/tissueb... @uci_cannabis #CannabisResearch #THCResearch

🧪 New ICAL protocol paper: Standardized methods for administering THC to adolescent & adult mice. Includes prep, legal compliance, and key readouts: catalepsy, locomotion, nociception. 🔗 app.jove.com/t/68358 🧠 Essential for modeling developmental effects of cannabis. #THC #CannabisResearch #ICAL

🚨 Vaping THC ≠ smoking it. In Science at the Source Ep. 4, Dr. Alexa Torrens breaks down how vaping affects the teen brain—& why the nose matters more than you think. Watch: www.youtube.com/watch?v=D9hc... Follow → @uci_cannabis #CannabisResearch #THCVaping #AdolescentBrain #ScienceAtTheSource

🎙️ Revisit this must-hear convo! Dr. Hilary Marusak talks with Dr. Kwang-Mook Jung about adolescent THC exposure & long-term metabolic health. 🔥 Why are cannabis users leaner? 🧬 How THC alters fat & energy use? 🌿 Endocannabinoid insights await. 🎧 youtu.be/RO_g9KTaMCA #ScienceAtTheSource #THC

🚨 Researchers! Free brain & peripheral tissues from adolescent THC-exposed rodents via the ICAL Tissue Bank at UCI. ✅ No DEA license needed ✅ Great for pilot data & grants 🌍 Open globally (shipping not covered) Apply early—high demand! 🔗 cannabis.uci.edu/ical/tissueb... #CannabisResearch #THC

🌿 Re-sharing this fascinating episode! Is cannabis a psychedelic? Dr. Daniele Piomelli explores this question in a 20-minute lecture from our Science at the Source series. Watch (or re-watch) now ➡️ youtu.be/G0tagjX8COw #CannabisResearch #Psychedelics #Neuroscience #ICAL

🌿 How does cannabis impact the brain across the lifespan? 🎥 Check out Science at the Source from UC Irvine’s ICAL. Dr. Daniele Piomelli breaks it down. 👉 Watch: youtu.be/Px45H-wuROA Follow: @uci_cannabis #CannabisResearch #ICAL #ScienceAtTheSource

🚨 Researchers! Access FREE brain & organ tissues from adolescent THC-exposed rodents via the ICAL Tissue Bank @ UCI. No DEA license needed. Great for pilot data & grant apps. Apply now—brain tissues go fast! 📦 cannabis.uci.edu/ical/tissueb... #CannabisResearch #THC

🧠 FAAH inhibitors may offer a new path for PTSD treatment. A 2023 preclinical study from ICAL shows that boosting endocannabinoid signaling with novel FAAH blockers (ARN14633 & ARN14280) ⬇️ anxiety-like behavior in rats exposed to predator stress. No major side effects. 🔗 doi.org/10.1007/s002...

🧬 Recent ICAL study: THC reduces pain in a humanized mouse model of sickle cell disease. Acute THC eased mechanical + cold hypersensitivity without affecting memory or anxiety. Chronic use helped too—but tolerance emerged. 🔗 doi.org/10.1124/jpet... #SCD #CannabisResearch #THC #PainScience #ICAL #UCI

🧬 New ICAL study: Adolescent THC exposure in male mice led to lower sperm count, testicular damage, and hormone disruption—effects not seen with adult exposure. Adolescence may be a critical window of vulnerability. 📄 doi.org/10.1093/toxs... #CannabisResearch #ReproductiveHealth #THC #Adolescent

🎙️ New ep! Microglia, addiction, & early career science w/ Maricela Martinez (@ucirvine PhD student) 🧠 Brain-immune circuits in adolescence 🌿 How THC, nicotine, opioids affect microglia 🔁 Can we reset drug-altered brain immunity? 🎧 Listen: www.youtube.com/watch?v=koYL... #Neuroimmunology

🎙️ New Science at the Source episode! Dr. Hilary Marusak talks with Dr. Steve Mahler (UC Irvine) about THC, craving, and the brain’s reward systems. 🎧 Don’t miss this deep dive into addiction + cannabis research. 🔗 www.youtube.com/watch?v=9ImB... @uci_cannabis #Neuroscience #THC

🚨 WE’RE MOVING! 🚨 Stay connected with the UCI Center for the Study of Cannabis 🌿🧠 Follow us for updates, research, and events: 📸 Instagram: @uci_cannabis 🌤️ Bluesky: @UCICANNABIS ▶️ YouTube: @ucicenterforthestudyofcann5100 💼 LinkedIn: @UCICANNABIS 🔍 Follow us and stay tuned!

🧠 New from ICAL: Microglia & Addiction Risk ICYMI—Drs. Martinez & Mahler explore how adolescent drug use may alter microglial function + raise long-term addiction risk. 📖: www.sciencedirect.com/science/arti... 🎙️ Author interview coming soon! 📲 IG: @uci_cannabis | BlueSky: @ucicannabis.bsky.social

🚨 YouTube Talk Can cannabis help manage chronic pain? 🌿🧠 Dr. Daniele Piomelli (UCI) explains how THC interacts with cannabinoid receptors to relieve pain. 🔥 Topics: ✅ How THC eases pain ✅ Cannabinoid receptors ✅ Scientific evidence + mechanisms 📺: www.youtube.com/watch?v=A7T1...

⭐ There is still time to register⭐ The International Cannabinoid Research Society (ICRS) will host its 35th annual Symposium from July 6-10, 2025 – in Bloomington, Indiana. Don't miss it! Learn more and register: www.icrs.com/2025-symposium

ICAL Director Dr. Daniele Piomelli explores PEA — a compound key for inflammation, pain relief, and the endocannabinoid system. 🔥 Topics: ✅ PEA’s science & history ✅ ECS interactions ✅ Health benefits & research 📺 Watch now:https://www.youtube.com/watch?v=wPoHFIrIHC0

🚗💨 Workshop Video! 💨🚗 How does cannabis affect driving? UCI’s Center for the Study of Cannabis dives into this complex issue with experts from UC, AAA, policy, and law. 📺 Watch: www.youtube.com/watch?v=e1hM... 📲 Follow: @ucicannabis.bsky.social #CannabisAndDriving

🚨 ICAL research spotlight🚨 Vaped THC in adolescent rats leads to high nasal accumulation and local metabolism—suggesting the nose plays a bigger role than we thought in THC delivery to the brain. 🧠👃 📄 Torrens et al. 2023, Pharmacol Res 🔗 PMID:

🚨 New Science at the Source! 🎥 Dr. Hilary Marusak & Dr. Alexa Torrens (UC-Irvine ICAL) explore how vaping cannabis impacts the adolescent brain 🧠💨 📺 Watch: www.youtube.com/watch?v=D9hc... 📲 Follow: @uci_cannabis | @ucicannabis.bsky.social #CannabisResearch #THC #Vaping

Join the UCI Center for the Study of Cannabis workshop on Cannabis and Driving, featuring Dr. Marilyn Huestis! She’s an expert on the effects of cannabis use while driving and cannabinoid pharmacology. 📺 Watch here: www.youtube.com/watch?v=4JZL... #CannabisResearch #DrivingSafety #UCI

🎥 The Health Impact of Cannabis – A talk by Dr. Daniele Piomelli, Director of the UCI Center for the Study of Cannabis. Learn about cannabis and its effects on health from a leading expert! 📺 Watch now: www.youtube.com/watch?v=M8-F... #CannabisResearch #Neuroscience #EndocannabinoidSystem #UCI

📢 New Publication! 📢 New ICAL study in Psychopharmacology examines how adolescent THC exposure affects cognitive processes in male and female rats. Read more here: buff.ly/wo5y1YQ #CannabisResearch #THC #Cognition

🌿✨ Want to cut through the cannabis misinformation? Check out our YouTube channel for expert insights and the latest research on cannabis science! 🔍 Subscribe now: buff.ly/3Xo9N6z #Canna#CannabisScience #UCIResearch

🌿🎙️ New Episode! 🎙️🌿 Tune in to Episode 3 of Science at the Source with Dr. Hilary Marusak and Dr. Kwang-Mook Jung as they explore adolescent THC exposure and metabolic health! 🎧 Listen: https://buff.ly/43anhXs Follow us: Instagram: @uci_cannabis | Bluesky: @ucicannabis

🌱 SAVE THE DATE: ICRS 2025 Symposium 🌱 Join us July 6-10, 2025 in Bloomington, IN for the 35th Annual ICRS Symposium! Expect: 50+ oral presentations 🎤 8 global plenary speakers 🌍 200+ poster sessions w/ live Q&A 🧑‍🔬 Networking roundtables & more! 🔗

🌿 Is cannabis a psychedelic? Dr. Daniele Piomelli dives into this fascinating question in our latest Science at the Source episode! Watch the 20-min lecture now ➡️ https://buff.ly/41cGFS6 #CannabisResearch #Psychedelics #Neuroscience #ICAL

🚨 Science Funding at Risk – Must-Listen 🚨 NIH cuts threaten research, training & patient care. Cannabis researchers Drs. Christine Rabinak, Alaina Jaster & Hilary Marusak discuss—plus Dr. Rabinak shares her perspective as a cancer patient. Listen & share: open.spotify.com/episode/7wrp...

🎬 New YouTube Series: Science at the Source! 🎬 Join Dr. Hilary Marusak as she interviews Dr. Daniele Piomelli on the latest in cannabinoid research from UC Irvine's ICAL. 🧠🌿 👉 Watch now: https://buff.ly/40U3QAw 🔗 Follow us on Instagram (@uci_cannabis) & Bluesky (@ucicannabis.bsky.social).

🧠 New ICAL Research! 🌱 Adolescent THC disrupts adult metabolism: ⚡️ Less fat & obesity resistance ⚠️ Impaired thermogenesis & health 📄 Study: https://buff.ly/3Cqwlw9 Follow: @ucicannabis #CannabisResearch #THC #Metabolism

🧠 Calling researchers! UCI ICAL Tissue Bank offers free brain & organ samples from rodents treated with Δ9-THC or vehicle (adolescent exposure). 🔬 Perfect for prelim. data, esp. if you lack a DEA Schedule-I license 📝 Apply now- in high demand! @ucicannabis #CannabisResearch

🌟 Meet Dr. Daniele Piomelli, Director of UCI ICAL! 🌟 A global leader in cannabinoid research, Dr. Piomelli is advancing discoveries on the endocannabinoid system and cannabis' role in health. Follow for more updates from this NIDA Center of Excellence! 🔬 👉 🔗 BlueSky: @ucicannabis.bsky.social

🚨 Save the Date! 🚨 Join us for the 2025 California Cannabis Research Workshop on March 25, 2025, 9 AM - 4 PM PST, at Tsakopoulos Library Galleria, Sacramento & via Zoom (Hybrid). 🌿 Discussions on cannabis research, funding, compliance, & legal trends. #CannabisResearch #SaveTheDate

🌟 UCI ICAL is back! We’re proud to relaunch the UCI Interdisciplinary Center for the Study of Cannabis & Cannabinoids—a NIDA Center of Excellence advancing #cannabisresearch. Follow us for updates! 🌱🔬 👉 IG: @uci_cannabis 👉 X: @ucicannabis 👉 BlueSky: @ucicannabis.bsky.social