Designing replication sequences is challenging in #SynBio. Researchers at the Innovative Genomics Institute present OriGEN, a language model generating functional plasmids beyond wild type, capturing the complex mechanisms of biological replication. 👉 doi.org/10.1101/2025...

🚀 Meet Constructive Bio! This biotech turns living bacteria into programmable biofactories creating new classes of polymers. At #SEVA, we love seeing initiatives like this driving innovation in #SynBio. Read more 👉 www.nature.com/articles/s41...

💭 Imagine #SynBio research where every experiment can be easily replicated and labs collaborate seamlessly. No technical hurdles, just shared progress. That’s our vision at #SEVA! Get your free plasmids and join the movement for #standardisation 👉https://seva-plasmids.com/

Pseudomonas chlororaphis is a promising biofactory, but hard to engineer. A new piece of work has characterised its endogenous CRISPR/Cas I–F system and built a precise editing & CRISPRi toolkit, enabling efficient genetic manipulation. Take a look 👉 pubs.acs.org/doi/10.1021/...

Looking for efficient ways to program intercellular communication? 🧬 Researchers at Micalis Institute present a phagemid toolbox —with #SEVA-based variants— for DNA delivery and next-gen multicellular circuits. 👉 doi.org/10.1101/2025...

The evolution of #SynBio advances with new regulatory toolboxes 🧬 This review explores devices from switches & logic gates to memory modules, powering circuits for bioproduction, therapeutics & biosafety — maybe you’ll find the ideal one for your research 👉 doi.org/10.3389/fsyb...

🌊 Marine bacteria like Pseudovibrio hold enormous ecological & biotech potential, still largely unexplored.✨ Discover the new SEVA-based genetic toolbox developed by researchers at the University of Illinois Chicago — opening ways to study their biology & new applications👉 doi.org/10.1128/aem....

What makes a SEVA plasmid unique? It’s built around 3 fundamental modules: 1️⃣ Origin of replication 2️⃣ Selection marker 3️⃣ Cargo With this open standard, you can design predictable and efficient genetic systems in bacteria and yeast. 👉 Learn more here: seva-plasmids.com

🧬 How many plasmids can a single bacterium carry? That’s the question Cholpisit Kiattisewee explores in his review on multi-plasmid systems and their impact on #SynBio. And yes, #SEVA is part of the debate 👀 👉 Read the full article: doi.org/10.1098/rsob...

⚠️ Hold on! Don’t scroll! Still don't know the basic design of a SEVA plasmid? 🧩 Combine modular parts and get your own standard plasmid from @SEVAplasmids for free. Find your match here 👇 seva-plasmids.com

Biology isn’t an exact science — but standardisation helps us get closer to reproducibility and clarity. That’s why @SEVAplasmids created a universal framework for plasmid vector design. Explore it here 👇 seva-plasmids.com

How do you imagine an artificial DNA nucleus? This study presents a synthetic DNA protonucleus that enables localized RNA transcription and condensation into nuclear-like architectures. A novel tool to investigate real nuclear function. Take a look 👉 doi.org/10.1038/s414...

🚀 #SEVA proves its potential once again! @norholm.bsky.social's lab created a new plasmid recombination system in E. coli using SEVAplasmids. Compatible with any copy number, they expand the standardised toolbox for #SynBio 👉 doi.org/10.1038/s420...

⏳ Stop wasting hours searching for the perfect plasmid for your experiment. 👉 Discover @SEVAplasmids — a community-driven, non-profit collection of standardised plasmids. 🔬 Open, reliable, and ready for your research. Check it out here 👇 seva-plasmids.com

📰 A computational analysis reveals 3️⃣ scaling laws of plasmids. Longer plasmids have: 1️⃣fewer copies 2️⃣more protein-coding 3️⃣more metabolic genes And with gradual adoption of chromosome-like features as they become longer. For more details 👉 doi.org/10.1038/s414...

🧬🔧X. autotrophicus, despite its metabolic flexibility and biosynthetic potential, has few genetic tools available. Researchers from Northeastern University introduce a new toolbox for this microbe, enabling optimisation of processes like bioremediation👉https://doi.org/10.1021/acssynbio.4c00455

📢 A study in Nature Communications presents a new framework that integrates scalable orthogonal amplifiers into standardised biological processes, increasing precision, adaptability, and signal-to-noise ratio in complex genetic circuits. Read the full study here👉 doi.org/10.1038/s414...

With #SEVAplasmids you’re just 2 steps away from your ideal plasmid! 1️⃣ Design your plasmid 2️⃣ Fill in the super simple order form That’s it —your customised plasmids will be shipped straight to your lab 🚀 at no cost Start now👉 seva-plasmids.com/contact/

🧑🤝🧑CRISPR/Cpf1 × pSEVA: a powerhouse combo in #SynBio! German researchers applied this strategy in Photorhabdus & Xenorhabdus, boosting production of high-value compounds like safracin B, a precursor to the anti-cancer drug ET-743. Read here👉 doi.org/10.1186/s129...

Meet one of our partners: @proftomellis.bsky.social's Lab, advancing genetically modified living materials. They use bacteria and yeast to create innovative biomaterials and were key in expanding SEVA from bacteria to eukaryotes. Find out more 👉https://www.tomellislab.com/our-research

#SynBio never ceases to amaze: a new study has succeeded in increasing energy metabolism in mammalian cells, algae, and fungi through the expression of E. coli LplA, a lipoylation protein. The result? Read here 👉 doi.org/10.1038/s414...

Why choose between standardisation and adaptability when you can have both? With #SEVA, you can mix and match: ✅ Antibiotic resistance marker ✅ Origins of replication ✅ Cargo modules for your experiment Build your reproducible #SynBio project here👉 seva-plasmids.com

Meet one of our partners: @proftomellis.bsky.social's Lab, advancing genetically modified living materials. They use bacteria and yeast to create innovative biomaterials and were key in expanding SEVA from bacteria to eukaryotes. Find out more 👉https://www.tomellislab.com/our-research

🚨 News for marine biosafety: Chinese researchers engineered a Vibrio natriegens strain, capable of degrading five water organic contaminants: biphenyl, phenol, naphthalene, dibenzofuran, and toluene. Find out how they did it 👉https://doi.org/10.1038/s41586-025-08947-7

⏳Looking for fast genome editing systems? Researchers from @uwaterloo.ca & Chinese Academy of Sciences created an all-in-one plasmid CRISPR/Cas9 system for Pseudomonas putida KT2440, enabling a genome edit in less than 1.5 days. Explore the work 👉 doi.org/10.1186/s129...

3️⃣ 2️⃣ 1️⃣... Not a countdown—it’s the standard code of one of our plasmids! 3️⃣: Cm resistance 2️⃣: RK2 origin of replication 1️⃣: MCS-default cargo Put them together, and voilà: pSEVA321 plasmid. Simple as that! Find more standardised plasmids here👉 seva-plasmids.com/find-your-pl...

Creating complete biosynthetic pathways from scratch can be a nightmare. SubNetX is a tool that helps you design and integrate them into whole-cell models, optimising the production of complex biochemical compounds. Discover how it works 👉 doi.org/10.1038/s414...

Could lignin waste inspire the biomanufacturing of the future? An international team evolved Acinetobacter baylyi to consume multiple lignin-derived aromatics simultaneously, paving the way for circular bio-based production. Read the article: 👉 doi.org/10.1093/jamb...

SynBio still needs tools enabling independent & precise co-expression of multiple genes. Researchers at Wrocław University presented a new plasmid set with 4 regulatory systems applied in E.coli, enabling independent induction of up to 3 genes in a single vector. Learn more 👉 doi.org/10.1186/s130...

🧬 Simplify your genetic engineering! #SEVAplasmids offers a growing collection of modular, “plug-and-play” plasmids designed to accelerate #SynBio workflows. Choose, combine, and customise with confidence thanks to our clear standards. 👉 seva-plasmids.com

New #SynBio tool! Juan Nogales' lab presents GENIO, a platform for precise genome integration in Pseudomonas putida inspired by #SEVAplasmids’ modular design. It helps you optimise genetic circuit performance for complex synbio design. Learn more: doi.org/10.1111/1751...

🎯 Looking for a plasmid with specific features? Use our #SEVAplasmids selector to filter by origin, antibiotic resistance, or cargo. 👉 Find your right tool in seconds: seva-plasmids.com/select-a-pla...

🔬 A new microbial platform shows enhanced resistance to heavy metals thanks to phosphomelanin biosynthesis—plus it degrades metallised plastic waste! This could offer promising options for environmental cleanup. Read more 👉 doi.org/10.1038/s414...

🧬 Understanding a plasmid’s structure at a glance? Our interactive map makes it possible. Explore SEVA’s modular architecture and its standardised nomenclature.🔍 ORI, markers, cargo… all just one click away 👉 seva-plasmids.com/backbone-mod...

🤝 Meet Lars M. Blank, partner of #SEVAplasmids community. His laboratory works to advance the bioeconomy by exploring microbial metabolism to transform CO₂, biomass, and plastic waste into valuable chemicals. Meet other collaborators: seva-plasmids.com/the-seva-com...

🌱Researchers at the University of Minnesota engineered a strain of Azotobacter vinelandii to release nitrogen as urea. According to their paper, they achieved a 43× higher yield than before. A promising advance for sustainable agriculture and next-gen biofertilisers 👉 doi.org/10.1111/1751...

🌞 Summer break is here! The activity of @sevaplasmids.bsky.social is paused for the holidays, so plasmid shipments are on hold until September. 🧬 You can still place your orders — we'll get back to you when we return. See you in September!

📢New for wastewater decontamination. A new study explores how the mobile element IS1071 can speed up pesticide degradation in an on-farm biopurification system. By mobilising catabolic genes in microbes, it helps detoxify wastewater more efficiently. Read more👉 doi.org/10.1111/1462...

Curious about jumbo phages? Dive into the fascinating world of phage 201ϕ2-1 — discover new insights into its transcription machinery and how it could be harnessed for synthetic biology applications. Sounds exciting? Take a look 👉https://doi.org/10.1111/1751-7915.70037

🤝Meet one of our #SEVAplamids community members: Dr.Jens Kromer’s lab. The group works on cell factories for fuels, chemicals and therapeutics, marine sponges and valorizes photosynthetic, CO₂ and sunlight products. Meet other partners👉 seva-plasmids.com/the-seva-com...

New step in metabolic engineering! A genome editing system for Caldimonas thermodepolymerans develops: ✅ a chassis strain (AI01) with improved transformation efficiency ✅ a mutant (ΔphaC) for polyhydroxyalkanoates synthesis See how: 👉 doi.org/10.1111/1751...

#SEVAplasmids for standardisation! In @angelgm.bsky.social 's lab they have used SEVA plasmids for the development of three standardised quorum sensing systems comprising transmitter and receiver modules 👉 doi.org/10.1021/acss...

What’s behind pSEVA237M? Each #SEVAplasmid name is a standard which encodes 3 modular elements: 1️⃣ 2 → Kanamycin resistance 2️⃣ 3 → pBBR1 origin of replication 3️⃣ 7M → msfGFP cargo And you can add a gadget in position 4️⃣ Find more codes or create yours 👉 seva-plasmids.com

What ways to produce lignans de novo can you think of? Researchers at the Chinese Academy of Sciences made it by mimicking plant metabolism in a consortium of synthetic yeasts. Find out in detail: 👉https://doi.org/10.1038/s41589-025-01861-z

🔍Problems with synthetic C1 metabolism? The @pabnik.bsky.social group identifies seven major barriers limiting its deployment in microorganisms and proposes specific strategies to overcome each of them. Check out their paper 👉https://doi.org/10.1093/femsre/fuaf011

📹Got 2 minutes? Meet us in this short video and see how #SEVA helps you do more effective synthetic biology with standardised plasmids👉 youtu.be/I8gZjXDRQ2I?...

🔥Bye Crabtree! At Hunan University, researchers reprogrammed S. cerevisiae to bypass the Crabtree effect, boosting lactate & 3-hydroxypropionic production by 8-11 times. A major step toward carbon-efficient biomanufacturing 👉https://www.nature.com/articles/s41467-025-60578-8

🧬 The language of SEVA expands! The group of @pabnik.bsky.social use #SEVAplasmids nomenclature in the design of CIFR—a novel iterative transposon tool for genomic engineering of Gam-negative bacteria. 👉 doi.org/10.1016/j.ym...

Bring your ideas to life with standardised plasmids. You only have to: ✅Remove restriction sites ✅Combine cargos and markers. ✅Send your construct to #SEVA And see how you contribute to reproducible results and efficient scalability. Try it now👉 seva-plasmids.com

New phi15-based expression system in Pseudomonas putida uses #SEVA plasmids for high-yield gene expression. The work by @pabnik.bsky.social shows how single-copy vectors minimise toxicity, achieve 200×induction, and outperform T7 systems. 👉 www.nature.com/articles/s42...