🧑🤝🧑CRISPR/Cpf1 × pSEVA: a powerhouse combo in #SynBio! German researchers applied this strategy in Photorhabdus & Xenorhabdus, boosting production of high-value compounds like safracin B, a precursor to the anti-cancer drug ET-743. Read here👉 doi.org/10.1186/s129...

Meet one of our partners: @proftomellis.bsky.social's Lab, advancing genetically modified living materials. They use bacteria and yeast to create innovative biomaterials and were key in expanding SEVA from bacteria to eukaryotes. Find out more 👉https://www.tomellislab.com/our-research

#SynBio never ceases to amaze: a new study has succeeded in increasing energy metabolism in mammalian cells, algae, and fungi through the expression of E. coli LplA, a lipoylation protein. The result? Read here 👉 doi.org/10.1038/s414...

Why choose between standardisation and adaptability when you can have both? With #SEVA, you can mix and match: ✅ Antibiotic resistance marker ✅ Origins of replication ✅ Cargo modules for your experiment Build your reproducible #SynBio project here👉 seva-plasmids.com

Meet one of our partners: @proftomellis.bsky.social's Lab, advancing genetically modified living materials. They use bacteria and yeast to create innovative biomaterials and were key in expanding SEVA from bacteria to eukaryotes. Find out more 👉https://www.tomellislab.com/our-research

🚨 News for marine biosafety: Chinese researchers engineered a Vibrio natriegens strain, capable of degrading five water organic contaminants: biphenyl, phenol, naphthalene, dibenzofuran, and toluene. Find out how they did it 👉https://doi.org/10.1038/s41586-025-08947-7

⏳Looking for fast genome editing systems? Researchers from @uwaterloo.ca & Chinese Academy of Sciences created an all-in-one plasmid CRISPR/Cas9 system for Pseudomonas putida KT2440, enabling a genome edit in less than 1.5 days. Explore the work 👉 doi.org/10.1186/s129...

3️⃣ 2️⃣ 1️⃣... Not a countdown—it’s the standard code of one of our plasmids! 3️⃣: Cm resistance 2️⃣: RK2 origin of replication 1️⃣: MCS-default cargo Put them together, and voilà: pSEVA321 plasmid. Simple as that! Find more standardised plasmids here👉 seva-plasmids.com/find-your-pl...

Creating complete biosynthetic pathways from scratch can be a nightmare. SubNetX is a tool that helps you design and integrate them into whole-cell models, optimising the production of complex biochemical compounds. Discover how it works 👉 doi.org/10.1038/s414...

Could lignin waste inspire the biomanufacturing of the future? An international team evolved Acinetobacter baylyi to consume multiple lignin-derived aromatics simultaneously, paving the way for circular bio-based production. Read the article: 👉 doi.org/10.1093/jamb...

SynBio still needs tools enabling independent & precise co-expression of multiple genes. Researchers at Wrocław University presented a new plasmid set with 4 regulatory systems applied in E.coli, enabling independent induction of up to 3 genes in a single vector. Learn more 👉 doi.org/10.1186/s130...

🧬 Simplify your genetic engineering! #SEVAplasmids offers a growing collection of modular, “plug-and-play” plasmids designed to accelerate #SynBio workflows. Choose, combine, and customise with confidence thanks to our clear standards. 👉 seva-plasmids.com

New #SynBio tool! Juan Nogales' lab presents GENIO, a platform for precise genome integration in Pseudomonas putida inspired by #SEVAplasmids’ modular design. It helps you optimise genetic circuit performance for complex synbio design. Learn more: doi.org/10.1111/1751...

🎯 Looking for a plasmid with specific features? Use our #SEVAplasmids selector to filter by origin, antibiotic resistance, or cargo. 👉 Find your right tool in seconds: seva-plasmids.com/select-a-pla...

🔬 A new microbial platform shows enhanced resistance to heavy metals thanks to phosphomelanin biosynthesis—plus it degrades metallised plastic waste! This could offer promising options for environmental cleanup. Read more 👉 doi.org/10.1038/s414...

🧬 Understanding a plasmid’s structure at a glance? Our interactive map makes it possible. Explore SEVA’s modular architecture and its standardised nomenclature.🔍 ORI, markers, cargo… all just one click away 👉 seva-plasmids.com/backbone-mod...

🤝 Meet Lars M. Blank, partner of #SEVAplasmids community. His laboratory works to advance the bioeconomy by exploring microbial metabolism to transform CO₂, biomass, and plastic waste into valuable chemicals. Meet other collaborators: seva-plasmids.com/the-seva-com...

🌱Researchers at the University of Minnesota engineered a strain of Azotobacter vinelandii to release nitrogen as urea. According to their paper, they achieved a 43× higher yield than before. A promising advance for sustainable agriculture and next-gen biofertilisers 👉 doi.org/10.1111/1751...

🌞 Summer break is here! The activity of @sevaplasmids.bsky.social is paused for the holidays, so plasmid shipments are on hold until September. 🧬 You can still place your orders — we'll get back to you when we return. See you in September!

📢New for wastewater decontamination. A new study explores how the mobile element IS1071 can speed up pesticide degradation in an on-farm biopurification system. By mobilising catabolic genes in microbes, it helps detoxify wastewater more efficiently. Read more👉 doi.org/10.1111/1462...

Curious about jumbo phages? Dive into the fascinating world of phage 201ϕ2-1 — discover new insights into its transcription machinery and how it could be harnessed for synthetic biology applications. Sounds exciting? Take a look 👉https://doi.org/10.1111/1751-7915.70037

🤝Meet one of our #SEVAplamids community members: Dr.Jens Kromer’s lab. The group works on cell factories for fuels, chemicals and therapeutics, marine sponges and valorizes photosynthetic, CO₂ and sunlight products. Meet other partners👉 seva-plasmids.com/the-seva-com...

New step in metabolic engineering! A genome editing system for Caldimonas thermodepolymerans develops: ✅ a chassis strain (AI01) with improved transformation efficiency ✅ a mutant (ΔphaC) for polyhydroxyalkanoates synthesis See how: 👉 doi.org/10.1111/1751...

#SEVAplasmids for standardisation! In @angelgm.bsky.social 's lab they have used SEVA plasmids for the development of three standardised quorum sensing systems comprising transmitter and receiver modules 👉 doi.org/10.1021/acss...

What’s behind pSEVA237M? Each #SEVAplasmid name is a standard which encodes 3 modular elements: 1️⃣ 2 → Kanamycin resistance 2️⃣ 3 → pBBR1 origin of replication 3️⃣ 7M → msfGFP cargo And you can add a gadget in position 4️⃣ Find more codes or create yours 👉 seva-plasmids.com

What ways to produce lignans de novo can you think of? Researchers at the Chinese Academy of Sciences made it by mimicking plant metabolism in a consortium of synthetic yeasts. Find out in detail: 👉https://doi.org/10.1038/s41589-025-01861-z

🔍Problems with synthetic C1 metabolism? The @pabnik.bsky.social group identifies seven major barriers limiting its deployment in microorganisms and proposes specific strategies to overcome each of them. Check out their paper 👉https://doi.org/10.1093/femsre/fuaf011

📹Got 2 minutes? Meet us in this short video and see how #SEVA helps you do more effective synthetic biology with standardised plasmids👉 youtu.be/I8gZjXDRQ2I?...

🔥Bye Crabtree! At Hunan University, researchers reprogrammed S. cerevisiae to bypass the Crabtree effect, boosting lactate & 3-hydroxypropionic production by 8-11 times. A major step toward carbon-efficient biomanufacturing 👉https://www.nature.com/articles/s41467-025-60578-8

🧬 The language of SEVA expands! The group of @pabnik.bsky.social use #SEVAplasmids nomenclature in the design of CIFR—a novel iterative transposon tool for genomic engineering of Gam-negative bacteria. 👉 doi.org/10.1016/j.ym...

Bring your ideas to life with standardised plasmids. You only have to: ✅Remove restriction sites ✅Combine cargos and markers. ✅Send your construct to #SEVA And see how you contribute to reproducible results and efficient scalability. Try it now👉 seva-plasmids.com

New phi15-based expression system in Pseudomonas putida uses #SEVA plasmids for high-yield gene expression. The work by @pabnik.bsky.social shows how single-copy vectors minimise toxicity, achieve 200×induction, and outperform T7 systems. 👉 www.nature.com/articles/s42...

🌊 Researchers at Shenzhen Institutes of Advanced Technology have engineered Vibrio natriegens to degrade five organic pollutants simultaneously! This represents a firm step in bioremediation research. 🔗 www.nature.com/articles/d41...

🧬 New tools for gene control! A recent publication highlights ligand-responsive condensates for controlled gene expression in mammalian cells. This modular system can target DNA, RNA, and proteins inside the nucleus.⬇️ www.nature.com/articles/s41...

A modular cloning strategy combining Golden Standard and MoClo enabled modular expression of PHB biosynthesis operons in E. coli, achieving notable polymer yields. A neat piece of work by Dr. Juan Nogales and his team. #SEVA plasmids put to great use! 🔗 academic.oup.com/nar/article/...

🔧 Need a custom plasmid for your #SynBio research? With #SEVA’s modular system, you can quickly assemble the perfect vector by combining origins, markers, and cargo. Simplify your workflow today! 👉 seva-plasmids.com

We use bacteria to create real-time images! British artist Howard Boland from C-LAB blurs the boundaries between art and science by using synthetic biology to create unique pieces of living art. 🎨 www.c-lab.co.uk/projects

🧬 Unlock the potential of synthetic biology with #SEVA plasmids! Our platform provides a vast range of standardised, easy-to-use vectors for all your experimental needs. Get started now: 👉 seva-plasmids.com

Researchers at @tsinghuauniversity.bsky.social used #SEVAplasmids to implement a lactose-inducible T7-like system in Halomonas bluephagenesis. This system achieves higher yield than IPTG-based systems reducing cost and toxicity👉 www.sciencedirect.com/science/arti...

Using modular, high-copy pSEVA351 #plasmids, researchers at UFZ improved enzyme activity under oxygenic conditions in Synechocystis. They were able to precisely control hydrogenase and maturation gene expression in Synechocystis⚙️ Read more 👉 link.springer.com/article/10.1...

👩‍🔬💻 Struggling with incompatible plasmids? #SEVA’s universal vector system guarantees compatibility across a variety of bacteria and yeasts, boosting reproducibility in your #SynBio experiments. Discover more: 👉 seva-plasmids.com

🔄 Collaborate with #SEVA! Share your plasmids and contribute to the growing database of open-source, modular vectors. Together, we can enhance reproducibility and progress in synthetic biology! 💪👉 seva-plasmids.com

🚀 Ready to level up your genetic engineering? #SEVA plasmids offer a user-friendly platform for seamless #SynBio work. Choose from a wide range of modules to build your ideal plasmid. Start building today: 👉

New study highlights #pSEVA plasmids for gene expression in Pseudovibrio brasiliensis, a versatile marine microbe involved in coral health. This tool enables fluorescent protein expression, boosting research on motility & metabolism. Read more 👉 journals.asm.org/doi/10.1128/...

Arsenic contamination remains a global challenge💧. By engineering Pseudomonas putida with #SEVA plasmids, enhanced arsenic accumulation was achieved, offering a scalable solution for #bioremediation 🌿. Read how #SEVA plasmids were used in this preprint 👉 papers.ssrn.com/sol3/papers....

🚨 Mupirocin production hits a key bottleneck: regulation. Thanks to #SEVA plasmids, researchers at Shanghai Jiao Tong University uncovered how Gac/Rsm regulation controls MupR/I quorum sensing and boosts mupirocin #biosynthesis. Explore the full study 👉 journals.asm.org/doi/10.1128/...

💡 With #SEVA plasmids, standardisation meets flexibility! Customise antibiotic markers, origins of replication, and cargo for your unique #SynBio experiments. Simplify your research and make it more reproducible: 👉 seva-plasmids.com

🌐On #WorldMetrologyDay, we highlight how standards drive scientific progress. Just like precise measurements, reliable tools are key in #SynBio research 📏. #SEVA plasmids provide modular, standardized vectors for reproducible, consistent results in your experiments.👉

🔬 In a recent study on Pseudomonas putida KT2440, Moreno et al. from @cnb-csic.bsky.social & @uam.es used #SEVA plasmids to create reporter systems for studying transposon activity. This enabled detailed transcriptional analysis, advancing our understanding of insertion sequence behavior! 👇

🔬 #SEVA continues to provide standardised, modular plasmids to advance #SynBio research and innovation. Build your custom vector from our diverse, well-documented options for smoother genetic engineering. Start today: 👉