A free, worldwide and standardized tool for researchers 🧑‍🔬🛠️ It seems too good to be true, but it exists! ⭕Our #SEVA plasmids accomplish all those characteristics to help scientific research succeed. Use them yourself! 👉

🩸🩹You may have heard about using glue to stop bleedings. Maybe it is not the best strategy in the world, but scientists have engineered bacteria to function as therapeutic ‘living glues’ inside your body! 😳. Check how they do it 👉

⭕ Plasmids of the group lncP-1 replicate and usually persist in many bacteria, but nothing in nature comes without exception. The lncP-1𝛃 plasmid pBP136 became extinct in E.coli at the lab. Scientists from the @uidaho.bsky.social suspect which gene is guilty. 👉

🧬Plasmids are the workhorses of molecular biology, but are we really choosing them wisely? @vdlorenzo.bsky.social and Esteban Martínez-García revisit what really defines plasmid performance and why modular standards like #SEVA matter for the future of #SynBio 👉https://doi.org/10.1111/1751-7915.70273

Have you already found your pSEVA plasmid match for your #SynBio project? You’re just one step away! 🚀 📤 Visit our website and choose the gateway to your next experiment—free, open, and ready to use 👉https://seva-plasmids.com/contact/

♻️🦠Tackling mixed plastics! See the potential of engineered microbial consortia to upcycle complex mixed plastic waste. Integrating transition metal-free plastic depolymerization with the strengths of each bacterial specialist and division of labor 👇 doi.org/10.1038/s414...

In need of a new #SEVA construct? Contributing to the community and to the plasmid repository is simple: 1. Remove unwanted and extra restriction sites 2. Flank every module with the appropriate SEVA-standard sites 3. Send your construct! 📋Check all the details seva-plasmids.com/description/...

🔬Investigating viral infections in a controlled way: researchers establish a cell-free T7 phage cycle on synthetic cells. A simplified but promising in vitro system for studying viral infection variables, phage-host interactions, and more. Full story👇 doi.org/10.1038/s414...

🦠⏩Beyond traditional organisms, broad-host-range synthetic biology offers a powerful framework for innovation, expanding chassis selection and rethinking their role in genetic design. Take a look at the perspective paper doi.org/10.1021/acss...

Let’s break down a pSEVA plasmid’s mix-and-match available modules! 🔵 Antibiotic resistance marker 🟡 Origin of replication 🔴 Cargo 🟢 and optional gadget Check our user-friendly platform and find the plasmids with the ideal modules for your research! 👉 seva-plasmids.com/find-your-pl...

🧬How selective pressures shape plasmid evolution within the host cell? Scientists have measured within-cell fitness of competing plasmids, revealing new insights into cell and plasmid dynamics and into how antibiotic resistance evolves in bacteria! Take a deeper look doi.org/10.1126/scie...

👩‍🔬Researchers use a SEVA plasmid to help develop citrOgen. A rapid platform that repurposes Citrobacter rodentium to present antigens from high-priority human pathogens, triggering the host to produce protective antibodies🛡️. 👉https://doi.org/10.1038/s41467-025-63922-0

A standardised plasmid repository for experimental replicability ⭕. Check #SEVAplasmids database and join the movement! 👉 seva-plasmids.com/find-your-pl...

✨And with that the 2025 season comes to an end... But at SEVA we continue working for a replicable and reliable science🤝 We want to thank you all for your support through this past year, and we can’t wait for all the surprises 2026 will bring! 🤩

📋Your plasmid and your plasmid documentation all in one place! Have a look at the possibility of plasmids with self-encoded documentation files 👉 doi.org/10.1016/j.ti...

👩‍🔬Can’t find your plasmid? We’ve got you covered! Design your own vector looking for the different pieces to assemble it yourself. All for free 👉 seva-plasmids.com

From a non-model organism to a promising industrial chassis✨. Have a look at the developments on synthetic biology tools and the engineering potential of Halomonas. SEVA plasmids have been used in some of these efforts, check the review 👉 doi.org/10.1186/s129...

🤝Professional labs around the globe are expanding SEVA and its standard. Meet our collaborators and learn about their research! seva-plasmids.com/the-seva-com...

👀 Researchers at University of Warwick explore how to maintain the expression of synthetic gene circuits over time in bacteria. They propose three genetic controllers that improve simple circuit half-life over threefold. Take a look 👉 doi.org/10.1038/s414...

A plasmid stabilization system offers a way to reduce antibiotic reliance in riboflavin bacterial production. Learn more about the solution 👇 👇 doi.org/10.1016/j.sy...

🎄🦠You don’t know what to give your lab team for Christmas this year yet? What about a customised plasmid perfect for your research? Have a look at our #SEVAplasmids database! 👉 seva-plasmids.com/find-your-pl...

💡A ”shred of light” on contaminants detection! A study shows promising combined biosensors for a more effective and rapid detection of toxins and contaminants. Take a look 👉https://doi.org/10.1016/j.bios.2025.117369

📖Have you used our #SEVAplasmids database selector? Consult our glossary for Acronyms and Antibiotics abbreviations to easily filter specific features. 👉https://seva-plasmids.com/find-your-plasmid/

💊 SMARTS biotool for smart #SynBio! This Streptomyces Multiplexed Artificial Control System boosts production of specific secondary metabolites in this species, which contribute to about half of drugs obtained from microorganisms! Learn more about it: doi.org/10.1038/s415...

🧬 Looking for the perfect plasmid? Explore our #SEVAplasmids database. Request any construct for free, or be the first to design one and share it with the community! Join the standard 👉 seva-plasmids.com/find-your-pl...

💡Glutamate from methanol? This study confirms that MscS channels in Bacillus methanolicus are key L-glutamate exporters, suggesting a way to unlock the bacterium’s potential for sustainable methanol-based glutamate production. Take a look 👉 doi.org/10.1111/1751...

🚀 New breakthrough! Researchers from the D-CHAB and the TUM Faculty of Natural Sciences have designed bacterial ABC transporters to efficiently import non-canonical amino acids. This achievement is a significant step towards expanding the genetic code. doi.org/10.1038/s415...

🚀 Take your genetic engineering to the next level! #SEVA plasmids give you a flexible, plug-and-play platform for your #SynBio designs. Mix, match, and build the plasmid you need, all in one place 👇 seva-plasmids.com/find-your-pl...

🤖 GPT goes #SynBio! Researchers at Chinese Academy of Sciences introduce SynBioGPT v2.0, an AI Large Language Model for SynBio that automates knowledge extraction and strain design. Tested on a 100-question SynBio benchmark, it achieved 98% accuracy! Take a look: doi.org/10.1101/2025...

🚨 News on bioremediation! A study published in Nature reveals how by genetically modifying the bacterium Vibrio natriegens, it simultaneously degrades five toxic contaminants in industrial wastewater and saline soils. Read the full article: www.nature.com/articles/d41...

👩🔬 Want to team up with us to expand the #SEVA collection? Contribute your own constructs to our open plasmid repository and help make #SynBio more reproducible for everyone. ✨ Check out our contribution guidelines and join the mission!👇👇 seva-plasmids.com

Designing replication sequences is challenging in #SynBio. Researchers at the Innovative Genomics Institute present OriGEN, a language model generating functional plasmids beyond wild type, capturing the complex mechanisms of biological replication. 👉 doi.org/10.1101/2025...

🚀 Meet Constructive Bio! This biotech turns living bacteria into programmable biofactories creating new classes of polymers. At #SEVA, we love seeing initiatives like this driving innovation in #SynBio. Read more 👉 www.nature.com/articles/s41...

💭 Imagine #SynBio research where every experiment can be easily replicated and labs collaborate seamlessly. No technical hurdles, just shared progress. That’s our vision at #SEVA! Get your free plasmids and join the movement for #standardisation 👉https://seva-plasmids.com/

Pseudomonas chlororaphis is a promising biofactory, but hard to engineer. A new piece of work has characterised its endogenous CRISPR/Cas I–F system and built a precise editing & CRISPRi toolkit, enabling efficient genetic manipulation. Take a look 👉 pubs.acs.org/doi/10.1021/...

Looking for efficient ways to program intercellular communication? 🧬 Researchers at Micalis Institute present a phagemid toolbox —with #SEVA-based variants— for DNA delivery and next-gen multicellular circuits. 👉 doi.org/10.1101/2025...

The evolution of #SynBio advances with new regulatory toolboxes 🧬 This review explores devices from switches & logic gates to memory modules, powering circuits for bioproduction, therapeutics & biosafety — maybe you’ll find the ideal one for your research 👉 doi.org/10.3389/fsyb...

🌊 Marine bacteria like Pseudovibrio hold enormous ecological & biotech potential, still largely unexplored.✨ Discover the new SEVA-based genetic toolbox developed by researchers at the University of Illinois Chicago — opening ways to study their biology & new applications👉 doi.org/10.1128/aem....

What makes a SEVA plasmid unique? It’s built around 3 fundamental modules: 1️⃣ Origin of replication 2️⃣ Selection marker 3️⃣ Cargo With this open standard, you can design predictable and efficient genetic systems in bacteria and yeast. 👉 Learn more here: seva-plasmids.com

🧬 How many plasmids can a single bacterium carry? That’s the question Cholpisit Kiattisewee explores in his review on multi-plasmid systems and their impact on #SynBio. And yes, #SEVA is part of the debate 👀 👉 Read the full article: doi.org/10.1098/rsob...

⚠️ Hold on! Don’t scroll! Still don't know the basic design of a SEVA plasmid? 🧩 Combine modular parts and get your own standard plasmid from @SEVAplasmids for free. Find your match here 👇 seva-plasmids.com

Biology isn’t an exact science — but standardisation helps us get closer to reproducibility and clarity. That’s why @SEVAplasmids created a universal framework for plasmid vector design. Explore it here 👇 seva-plasmids.com

How do you imagine an artificial DNA nucleus? This study presents a synthetic DNA protonucleus that enables localized RNA transcription and condensation into nuclear-like architectures. A novel tool to investigate real nuclear function. Take a look 👉 doi.org/10.1038/s414...

🚀 #SEVA proves its potential once again! @norholm.bsky.social's lab created a new plasmid recombination system in E. coli using SEVAplasmids. Compatible with any copy number, they expand the standardised toolbox for #SynBio 👉 doi.org/10.1038/s420...

⏳ Stop wasting hours searching for the perfect plasmid for your experiment. 👉 Discover @SEVAplasmids — a community-driven, non-profit collection of standardised plasmids. 🔬 Open, reliable, and ready for your research. Check it out here 👇 seva-plasmids.com

📰 A computational analysis reveals 3️⃣ scaling laws of plasmids. Longer plasmids have: 1️⃣fewer copies 2️⃣more protein-coding 3️⃣more metabolic genes And with gradual adoption of chromosome-like features as they become longer. For more details 👉 doi.org/10.1038/s414...

🧬🔧X. autotrophicus, despite its metabolic flexibility and biosynthetic potential, has few genetic tools available. Researchers from Northeastern University introduce a new toolbox for this microbe, enabling optimisation of processes like bioremediation👉https://doi.org/10.1021/acssynbio.4c00455

📢 A study in Nature Communications presents a new framework that integrates scalable orthogonal amplifiers into standardised biological processes, increasing precision, adaptability, and signal-to-noise ratio in complex genetic circuits. Read the full study here👉 doi.org/10.1038/s414...

With #SEVAplasmids you’re just 2 steps away from your ideal plasmid! 1️⃣ Design your plasmid 2️⃣ Fill in the super simple order form That’s it —your customised plasmids will be shipped straight to your lab 🚀 at no cost Start now👉 seva-plasmids.com/contact/

🧑🤝🧑CRISPR/Cpf1 × pSEVA: a powerhouse combo in #SynBio! German researchers applied this strategy in Photorhabdus & Xenorhabdus, boosting production of high-value compounds like safracin B, a precursor to the anti-cancer drug ET-743. Read here👉 doi.org/10.1186/s129...