Wei Bian
@weibian.bsky.social
📤 55
📥 39
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reposted by
Wei Bian
Matthias Soller
13 days ago
Elegant way to test for CRISPR-Cas9 off targets thanks to
@weibian.bsky.social
@davidmcquarrie.bsky.social
@roliarnold.bsky.social
@ihaussmann.bsky.social
but there seems very little. At least to say CRISPR-Cas9 is safe for flies
rdcu.be/eUyma
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Genetic evaluation of CRISPR-Cas9 off-target effects from deleterious mutations on Drosophila male single X chromosome
https://rdcu.be/eUyma
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reposted by
Wei Bian
Matthias Soller
about 1 year ago
Here is the link
platinum-crispr.bham.ac.uk/predict.pl
add a skeleton here at some point
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reposted by
Wei Bian
Matthias Soller
about 1 year ago
Excited to share our new paper describing how ELAV/Hu RNA binding proteins achieve binding specificity now in NAR thanks to fantastic
@davidmcquarrie.bsky.social
academic.oup.com/nar/article/...
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reposted by
Wei Bian
David McQuarrie
about 1 year ago
N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs
www.biorxiv.org/content/10.1...
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N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs
In humans, misprocessed mRNAs containing intact 5′ Splice Site (5′SS) motifs are nuclear retained and targeted for decay by ZFC3H1, a component of the Poly(A) Exosome Targeting complex, and U1-70K, a ...
https://www.biorxiv.org/content/10.1101/2023.06.20.545713v4?ct=
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