State of the art!

Excited to share an update of our work on modeling the human protein interactome in 3D using Boltz-2. Large-scale protein complex prediction allows for exploring structurally-informed biological networks. Preprint on bioRxiv: doi.org/10.1101/2025...

Eat your carrots or you'll go blind! The biochemical reason for this warning is that we need retinal, vitamin A, to form the pigment that absorbs light in our eyes. More at Molecule of the Month: pdb101.rcsb.org/motm/66 #PeakPerformance

Excited to share our work on modeling the human protein interactome in 3D. This currently includes 1,394 interaction structures predicted with Boltz-2. Grateful for the open-access resources making this possible! Preprint: doi.org/10.1101/2025...

Excited to share a new article I co-authored on the relationship between biological sequence and structure! We look back to historic hypotheses, and look forward to how AI/ML models may be developed to predict protein conformational dynamics. Paper: doi.org/10.1063/4.00...

Hemoglobin, the biomolecule that breathes, modeled with Boltz-2. With the recent release of #Boltz2, I gave it a try for modeling hemoglobin. Hemoglobin structures were likely included for training, and this was just a fun test, but it’s awesome to see this modeling in action!

Truly remarkable work. Looking forward to using it!

Dynamic insight into DNA → RNA → protein. Great work!

New RCSB PDB publication-- Read how Mol* can be used to visualize and analyze the influenza A H5N1 virus proteome pdb101.rcsb.org/news...

Computational capacity of life in relation to the universe | Science Advances www.science.org/doi/10.1126/...

Creative use of AlphaFold for predicting oligomeric states of proteins, nice work. www.biorxiv.org/content/10.1...

Predictomes (Schmid & Walter, 2025). This looks very useful! www.cell.com/molecular-ce...

Never gets old. #Discovery