Chance favors the (theoretically) prepared mind - arjunrajlab.substack.com/p/chance-fav...

I just thought everyone should see this

Why we (usually) don't have to worry about multiple comparisons - arxiv.org/abs/0907.2478

Serverless GPUs for fast TSNE visualization - www.nxn.se/p/serverless...

Life's most important problems - blog.jck.bio/p/lifes-most...

We predict that the transcript abundance from the gene we are knocking down will (checks notes) decrease - ekernf01.github.io/target_gene_...

The spectrum of inflammatory responses - doi.org/10.1126/scie...

Training SCVI - Metal acceleration - www.nxn.se/p/training-s...

Pertpy: a one-stop and performant framework for single-cell perturbation analysis. @lukasheumos.bsky.social @fabiantheis.bsky.social www.nature.com/articles/s41...

Assessing a Virtual Cell’s utility - blog.turbine.ai/p/assessing-...

PCA is one of those techniques that sounds unreasonable (yeah sure we all want to fit a p-dimensional ellipsoid to our data) but turns out to be a reasonable solution to a wide range of problems. Also: I do hope stackexchange has been archived, because it is my gen's library of alexandria

Citizen Kane is a good movie in general, but the one thing I can't stop thinking about is how thick and substantial the jigsaw puzzle pieces in it are. I've only experienced thin cardboard jigsaw puzzles; these wood ones must feel very satisfying.

Selective remodelling of the adipose niche in obesity and weight loss - www.nature.com/articles/s41...

SCVI - Estimating null expression levels -- www.nxn.se/p/scvi-estim...

Finally watched Contagion. Amazing movie! Especially in retrospect.

Hoping the mechnical keyboard community at some points discover the 'matter over thread' smart home world. All the current smart buttons are mushy and unsatisfying.

Why does anyone use the Wilcoxon test for anything? It's not even transitive. It's sensitive to things one most likely is not looking for (changes in distribution shape) and relatively insensitive to what one usually is looking for (change in location). www.sciencedirect.com/science/arti...

Virtual Cell Perturbation Metrics Reloaded - giovannipalla.substack.com/p/virtual-ce...

Interpretable Inflammation Landscape of Circulating Immune cells - www.biorxiv.org/content/10.1...

Claude agent skill to infer experimental designs from .h5ad’s - www.nxn.se/p/claude-age...

What will it take for AI to change drug discovery? - www.writingruxandrabio.com/p/what-will-...

We still can’t predict much of anything in biology - blog.genesmindsmachines.com/p/we-still-c...

The Truth Is Out There, Part 4: The Downside of Belief - www.filfre.net/2024/10/the-...

Hollywood Archaeology: The Super Mario Bros. Movie - grantland.com/features/the...

🧬 Tahoe Workshop at scverse conference 2025 🧬 Disease Biology and Therapeutics in the Age of Frontier Datasets @tahoetherapeutics.bsky.social #scverse2025 #ComputationalBiology #DrugDiscovery #TahoeTherapeutics #SingleCell #PerturbationBiology

MrVI, based on deep generative modeling, is a unified framework for integrative, exploratory, and comparative analyses of large-scale (multi-sample) single-cell RNA-seq datasets. @justjhong.bsky.social @canergen.bsky.social @elhamazizi.bsky.social www.nature.com/articles/s41...

Training SCVI — Differential expression over epochs - www.nxn.se/p/training-s...

A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS - www.nature.com/articles/s41...

A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma - www.nature.com/articles/s41...

Causal temperatures - www.nxn.se/p/causal-tem...

Negative binomial regression and inference using a pre-trained transformer - www.nxn.se/p/negative-b...

Hanseatic League - en.wikipedia.org/wiki/Hanseat...

The immunology of asthma and chronic rhinosinusitis - www.nature.com/articles/s41...

Alien: Earth (2025) - www.themoviedb.org/tv/157239-al...

The Truth Is Out There, Part 3: The Game of Belief - www.filfre.net/2024/10/the-...

THE LOTTERY OF FASCINATIONS - slatestarcodex.com/2013/06/30/t...

How pour-over coffee got good - worksinprogress.co/issue/how-po...

A Visual Guide to Gene Delivery - press.asimov.com/articles/gen...

The Day Novartis Chose Discovery - www.alexkesin.com/p/the-day-no...

What's going on with gene therapies? (Part one) - nehalslearnings.substack.com/p/whats-goin...

The immunology of asthma - www.nature.com/articles/s41...

Animals as chemical factories - worksinprogress.co/issue/animal...

The therapeutic potential of stem cells - royalsocietypublishing.org/doi/10.1098/...

The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about it - atelfo.github.io/2023/12/23/b...

Valentine Svensson Negative binomial regression and inference using a pre-trained transformer https://arxiv.org/abs/2508.04111

Negative binomial regression and inference using a pre-trained transformer - arxiv.org/abs/2508.04111

Overinterpreting underpowered multi-omics experiments - thecodon.substack.com/p/falling-in...

(1) Fitting hierarchical models in genetics, (2) A Stan model that runs faster with 400,000 latent parameters, (3) Super-scalable penalized maximum likelihood inference for biome problems, (4) “In the end, I basically gave up working on biology bec... - statmodeling.stat.columbia.edu/2025/07/31/b...

Using hierarchical modeling to get more stable rankings of gene expression - statmodeling.stat.columbia.edu/2025/07/30/u...