10x Flex preserves biological processes - www.nxn.se/p/10x-flex-p...

Unteaching school - luispedro.substack.com/p/unteaching...

Creating a Tahoe sculpture - www.nxn.se/p/creating-a...

Gaston Ramon’s Big Four - www.mdpi.com/2072-6651/16...

Neuron–eosinophil circuit explains stress-induced eczema flares - www.nature.com/articles/s41...

I don't think cell representation foundation models _should_ be good at zero-shot integrating data. How do you know which variation I want to integrate out?

I wonder if the first time you see semi-structured variation in real data when you need to analyze it (as opposed to nicely curated data used for eduction), imprints you to think of this variation as "the batch effect"

Overview of the reporter genes and reporter mouse models - onlinelibrary.wiley.com/doi/10.1002/...

Allelic exclusion of immunoglobulin genes: models and mechanisms - doi.org/10.1111/j.16...

When Baz Luhrman had the guns say "sword" on the side in Romeo + Juliet, that was the best choice that has been made in any modern adaptation ever.

i am basically always thinking about the idle thumbs day z episodes when playing this game

The one science reform we can all agree on, but we're too cowardly to do - www.experimental-history.com/p/the-one-sc...

Driftmachine: Spume & Recollection - open.spotify.com/album/5qFhCM...

A comprehensive analysis framework for evaluating commercial single-cell RNA sequencing technologies - doi.org/10.1093/nar/...

Probing the Feasibility of Single-Cell Fixed RNA Sequencing from FFPE Tissue - doi.org/10.3390/ijms...

Improving SCVI for low-count cells through self-supervised augmentation - www.nxn.se/p/improving-...

Interferons in health and disease - www.cell.com/cell/abstrac...

There's a lot of research being published

Home assistant trick: if you have a light switch tied to a wall socket, you can put a smart plug in the socket set to go to 'on' state when it powers on. That 'on' can trigger an event that 1) turns it off and 2) the off state triggers other events like smart bulbs. Now it's a smart button!

The Misuses of the University - www.publicbooks.org/the-misuses-...

The Origins of Adjuvants - press.asimov.com/articles/adj...

Improving SCVI for low-count cells through self-supervised augmentation https://www.biorxiv.org/content/10.64898/2026.02.11.705441v1

Chance favors the (theoretically) prepared mind - arjunrajlab.substack.com/p/chance-fav...

I just thought everyone should see this

Why we (usually) don't have to worry about multiple comparisons - arxiv.org/abs/0907.2478

Serverless GPUs for fast TSNE visualization - www.nxn.se/p/serverless...

Life's most important problems - blog.jck.bio/p/lifes-most...

We predict that the transcript abundance from the gene we are knocking down will (checks notes) decrease - ekernf01.github.io/target_gene_...

The spectrum of inflammatory responses - doi.org/10.1126/scie...

Training SCVI - Metal acceleration - www.nxn.se/p/training-s...

Pertpy: a one-stop and performant framework for single-cell perturbation analysis. @lukasheumos.bsky.social @fabiantheis.bsky.social www.nature.com/articles/s41...

Assessing a Virtual Cell’s utility - blog.turbine.ai/p/assessing-...

PCA is one of those techniques that sounds unreasonable (yeah sure we all want to fit a p-dimensional ellipsoid to our data) but turns out to be a reasonable solution to a wide range of problems. Also: I do hope stackexchange has been archived, because it is my gen's library of alexandria

Citizen Kane is a good movie in general, but the one thing I can't stop thinking about is how thick and substantial the jigsaw puzzle pieces in it are. I've only experienced thin cardboard jigsaw puzzles; these wood ones must feel very satisfying.

Selective remodelling of the adipose niche in obesity and weight loss - www.nature.com/articles/s41...

SCVI - Estimating null expression levels -- www.nxn.se/p/scvi-estim...

Finally watched Contagion. Amazing movie! Especially in retrospect.

Hoping the mechnical keyboard community at some points discover the 'matter over thread' smart home world. All the current smart buttons are mushy and unsatisfying.

Why does anyone use the Wilcoxon test for anything? It's not even transitive. It's sensitive to things one most likely is not looking for (changes in distribution shape) and relatively insensitive to what one usually is looking for (change in location). www.sciencedirect.com/science/arti...

Virtual Cell Perturbation Metrics Reloaded - giovannipalla.substack.com/p/virtual-ce...

Interpretable Inflammation Landscape of Circulating Immune cells - www.biorxiv.org/content/10.1...

Claude agent skill to infer experimental designs from .h5ad’s - www.nxn.se/p/claude-age...

What will it take for AI to change drug discovery? - www.writingruxandrabio.com/p/what-will-...

We still can’t predict much of anything in biology - blog.genesmindsmachines.com/p/we-still-c...

The Truth Is Out There, Part 4: The Downside of Belief - www.filfre.net/2024/10/the-...

Hollywood Archaeology: The Super Mario Bros. Movie - grantland.com/features/the...

🧬 Tahoe Workshop at scverse conference 2025 🧬 Disease Biology and Therapeutics in the Age of Frontier Datasets @tahoetherapeutics.bsky.social #scverse2025 #ComputationalBiology #DrugDiscovery #TahoeTherapeutics #SingleCell #PerturbationBiology

MrVI, based on deep generative modeling, is a unified framework for integrative, exploratory, and comparative analyses of large-scale (multi-sample) single-cell RNA-seq datasets. @justjhong.bsky.social @canergen.bsky.social @elhamazizi.bsky.social www.nature.com/articles/s41...

Training SCVI — Differential expression over epochs - www.nxn.se/p/training-s...

A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS - www.nature.com/articles/s41...