Thrilled to see our work featured on the cover of Molecular Cell. The image:electron micrograph of an i-loop, the DNA structure we propose as a source of eccDNA formation. We've spent years thinking about these structures. There's something quietly surreal about seeing one on the cover of a journal

Thrilled to see our work featured on the cover of Molecular Cell. The image is an electron micrograph of an i-loop, the DNA structure we propose as a source of eccDNA formation. Almost like catching circular DNA formation in the act. #eccDNA #CancerResearch #GenomeInstability #DNARepair

How do cancer-associated eccDNAs arise? Our work shows that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer. 1/2

It's hard to focus on Israel's airstrikes in Lebanon due to Israel's invasion of Syria, which is hard to focus on due to Israel's atrocities in the West Bank, which are hard to focus on due to Israel's genocide in Gaza, which is hard to focus on due to Israel's war on Iran.

Telomere Community 🧬 Can't wait for the new CSHL Monograph? Our review on unusual structure at Telomeric repeats is now live on Cold Spring Harbor Perspectives! Grab a few free PDFs here: cshperspectives.cshlp.org/cgi/reprint/... #CHSL #AcademicSky #Science @ezeta.bsky.social @cshlnews.bsky.social

I'm completely stunned by how fascinating this is. I've know for a while the beauty and intricacies of the mechanisms in action, but to be able to visualize them in such a way it's incredible. Kudos to @drewberry.bsky.social !

This is the energy we will need!!

ReVenge

Nobody came to save the Ukrainians, Palestinians, Syrians, or Burmese to name a few. Millions are facing hard fascism, authoritarianism, atrocities beyond comprehension. They haven't surrendered, we don't have an excuse to give up or beg to be saved, it's our duty to stand up for each other.