I am very happy to finally share SAFE-LD, a method convert genotypes to an anonymised privacy-preserving version to be used to precisely compute LD. Led by @gdesanctis.bsky.social Claudia Gianbartolomei @sodbo.bsky.social and Davide bolognini. 📄: shorturl.at/BgXqq Github: shorturl.at/b49Wa

In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox: For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?

Beats closest gene! @jengreitz.bsky.social @anshulkundaje.bsky.social And others that I can't find on bluesky. But if you're here let me know so I can follow you!