"an accurate pan-tissue, pan-histone-mark age predictor"😎 1814 ChIPseq samples H3K4me3 H3K27ac H3K9ac H3K9me3 H3K27me3 H3K36me3 H3K4me1 82 tissues (incld large arteries) "only a small fraction of the 62,241 features is sufficient to predict age" #SciAdv 2024 www.science.org/doi/10.1126/...

🔬𝐓𝐫𝐢𝐩𝐥𝐞-𝐍𝐞𝐠𝐚𝐭𝐢𝐯𝐞 𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐚𝐫𝐜𝐢𝐧𝐨𝐦𝐚 (𝐍𝐒𝐓) 🔬 ⚠️ Pitfall alert - TNBCs can have a range of morphologies - DCIS is usually absent - ❌ GATA3 - ✔️ SOX10 (mimic melanoma) - Always do keratin + review patients history #Breastpath #Dermpath #Pathtwitter #Pathresidents

⚕️ 𝗧𝗵𝗼𝗿𝗮𝗰𝗶𝗰 𝗦𝗠𝗔𝗥𝗖𝗔𝟰-𝗗𝗲𝗳𝗶𝗰𝗶𝗲𝗻𝘁 𝗨𝗻𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝘁𝗶𝗮𝘁𝗲𝗱 𝗧𝘂𝗺𝗼𝘂𝗿 (𝗦𝗗𝗨𝗧)⚕️ As discussion below: www.linkedin.com/posts/trista... #Pathtwitter #Pulmpath #BSTpath

𝐌𝐞𝐭𝐚𝐬𝐭𝐚𝐭𝐢𝐜 𝐅𝐮𝐦𝐚𝐫𝐚𝐭𝐞 𝐇𝐲𝐝𝐫𝐚𝐭𝐚𝐬𝐞 𝐃𝐞𝐟𝐢𝐜𝐢𝐞𝐧𝐭 𝐑𝐞𝐧𝐚𝐥 𝐂𝐞𝐥𝐥 𝐂𝐚𝐫𝐜𝐢𝐧𝐨𝐦𝐚 (𝐅𝐇𝐃 𝐑𝐂𝐂) 𝐅𝐇𝐃 𝐑𝐂𝐂 is a rare and highly aggressive tumour with a devastating prognosis—most cases present with metastases at diagnosis. Here’s what to know, a thread 🧵 #pathtwitter #GUpath #Medicine #Oncology #BSTpath