The Maurer Lab (@maurerlab.bsky.social)

Glad to share this finally! We explored how modulating host factors could improve dual rAAV vector transduction. Key takeaways: HDR inhibition boosts expression & concatenation, and transient HDRi enables lower doses & higher efficiency! More to come in the Maurer Lab. www.nature.com/articles/s41...

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Double-strand break repair pathways differentially affect processing and transduction by dual AAV vectors - Nature Communications AAV vectors are a promising gene delivery vehicle but have a limited DNA packaging capacity. Here, the authors identify cellular restriction factors whose temporary inhibition significantly enhances t... https://www.nature.com/articles/s41467-025-56738-5