Pre-print: our description of RZ affiliate ZNFX1 is now online. On binding viral RNA, ZNFX1 generates parallel Ub currents, coordinating Ub-dependent RNA silencing and aggregate resolution. Huge effort from first authors Dan Squair and @eilidhrivers.bsky.social www.biorxiv.org/content/10.1...

A wee summary of our paper: Tim and Juraj’s landmark paper from 2020 was the first to elucidate the structural and biochemical detail of RNF213, the largest known E3 and only AAA-E3 hybrid. Among many observations, two stood out: E3 activity was RING-independent and specific for the E2 UBE2L3.

A labor of love :)

This little tweezer followed me since the first day of my PhD with Stefania Spano. After four brilliant years with the @fletcherlab.bsky.social, it’ll be coming with me to a new chapter! It’ll be weird not to be working on gentle giant #RNF213, but really cool stuff is brewing, so watch this space.

It’s a great pleasure to advertise the pre-print of Emma’s OAS2 story! doi.org/10.1101/2025... One gene, two transcripts, two antiviral molecules with different virus targets, using different antiviral mechanisms… a great place to release into the community! Well done Emma!

Is there any way stain nuclear envelope? As in the lipid bilayer of the nucleus not the proteins… Please retweet to widen the reach :)

Messages loud & clear: Chris & Alex designed destabilized MS2 and PP7 coat proteins, which are degraded in cells except when bound to their cognate RNA hairpins. We used these probes to image distinct single mRNAs simultaneously in live cells, 'background-free.' AddGene soon! tinyurl.com/27p7hyt9

To bless the new app, here is an IF image of #RNF213, amongst many other things, forming beautifully shaped lipid droplets.