A novel strategy for improving our understanding of, and ability to utilise, nitrosation as a post-translational modification by a covalent binder strategy. Published in JACS by Jiangbing Wu and Zhangjian Huang. pubs.acs.org/doi/10.1021/...

Ich arbeite im selben Gebäude, in dem vor über hundert Jahren schon Wilhelm Ostwald und Ernst Beckmann gearbeitet haben, zwei große Namen der Chemie 🧑‍🔬 Deshalb war ich neugierig und habe mal ein wenig über die beiden recherchiert. Fangen wir mit Wilhelm Ostwald an 🧵

Diene-En Ring-Closing Metathesis has regioselectivity and cis/trans selectivity challenges. Jin-Ming Gao and colleagues from Northwest A&F #University showed it can be effective with their #totalsynthesis of ansatrienol K in the Journal of Organic Chemistry. pubs.acs.org/doi/full/10.... #chemistry

Yong-Qiang Tu’s team (Lanzhou) developed a highly enantioselective method to access α-ethynylated 3-substituted oxindoles using a hypervalent iodine reagent and triazolium catalyst. This unlocks key interm for alkaloid synthesis - demonstrated in Angew. Chem. onlinelibrary.wiley.com/doi/10.1002/...

German researchers isolated saarvienin A, a novel glycopeptide #antibiotic from Amycolatopsis. Reported by Rolf Müller in @angewandtechemie.bsky.social it overcomes vancomycin resistance in Gram-positive bacteria but also shows eukaryotic cytotoxicity. onlinelibrary.wiley.com/doi/10.1002/...

A synthetic methodology developed by chemists in India can obtain complex caged amines from readily attainable azolium bromide salts through a cascade of annulation reactions.

While disease treatments often inhibit proteins, #PROTAC degrade them via ubiquitinase-protease recruitment. Darci Trader @ucirvine.bsky.social now show in J Med Cem proteases can be recruitet without ubiquitinases — a still less potent but interesting alternative. pubs.acs.org/doi/10.1021/...

When you think of a reaction between an acid and an alcohol, you think of an ester as the product. David MacMillan and co-workers have now described a different pathway: Selective decarbonylative C-C coupling via a metal-catalyzed photoredox reaction. #chemistry pubs.acs.org/doi/10.1021/...

Luo et al. from Tsinghua University #China report in #JACS a novel method to create enantioenriched α-amino aldehydes using photocatalysis. Through this strategy α-amino aldehydes with up to 93% ee could be synthesised. me.organicchemistry.eu/post/deracem... #Chemistry #Research

J Tuccinardi and J Wood from Baylor University ( #USA), introduced a strategy to synthesize the core of aleutianamine. Their study in #JACS involved a vinylogous Mukaiyama-Michael reaction cascade using two previously unknown coupling partners. #chemistry me.organicchemistry.eu/post/aleutia...

Marburg, an RNA virus that belongs to the family of filoviruses, is causing an outbreak in Tanzania. No approved vaccines or therapeutics for Marburg virus disease exist. cen.acs.org/biological-c... 🧪 #scinews #biosky

Computer-aided synthesis: R. Shenvi (@shenvi.bsky.social) and C. Li published in #Nature the synthesis of 25 picrotoxanes. Their 1,5-HAT key reaction was challenged by β-scission, therefore DFT based calculations helped to design usable intermediates. Read more me.organicchemistry.eu/post/picroto...

Early this year Mingji Dai and his lab described the total synthesis of heilonine in #JACS (10.1021/jacs.3c13492). It is short and elegant, using multiple C-H functionalisations and a Nazarov cyclisation. Read more: www.organicchemistry.eu/books/total-... #chemistry #science #totalsynthesis

The most recent publication from our very productive collaboration with the flow chemistry experts at University Graz is now in print in Angewandte Chemie. Shown applications have high relevance for medicinal chemistry, especially in the #TPD space. onlinelibrary.wiley.com/doi/full/10....

Total Synthesis papers are amongst the most downloaded, which is a measure of importance & broad interest. Yet it’s not uncommon to have >10,000 downloads with <50 citations. If I were obsessed with my h-factor, I’d stop publishing total syntheses now. But you gotta what you truly love doing!

Synthetic chemists! If you haven’t discovered chemdle yet, you are missing out big time! Synthesis meets wordle! www.chemdle.com

New paper: I love this project because it spans three dissertations (Sam, Steven, and Tahoe) and because it gives me the opportunity to remind folks that the di-pi-methane reaction should by all rights be called the Zimmerman rearrangement. pubs.acs.org/doi/10.1021/...

Muscarine is a well-known toxin in mushrooms. Despite its importance in deadly poisoning, it's metabolic profile is poorly understood. In a new study published in Angewandte Chemie, researchers from the Leibniz HKI have identified a novel metabolite. onlinelibrary.wiley.com/doi/10.1002/...

Pleurotin is a benzoquinone meroterpenoid that was first isolated in the late 1940s. Recently, Ya-Qiu Long and his team from Soochow University (#China) published a novel synthetic route in the journal JACS Au. Read more here: www.organicchemistry.eu/books/total-... #chemistry

Efficient Synthesis of ProTide antivirals: A team from from #Fudan University and #Shanghai Jiao Tong University reporting a copper-catalyzed method for synthesizing chiral phosphates in #JACS. Read more: doi.org/10.1021/jacs.4c12920 #MedChem #Antivirals #Research #Science #Chemistry

Every student in #chemistry will encounter the Bredt rule at least once in their studies. Recently, a research team led by Neil K. Garg from the University of California (USA) published findings on access to anti-Bredt type olefins as intermediates in #Science. www.science.org/doi/10.1126/...

Hi, I am going to give this platform a try. My main account is on Mastodon but I feel there is a bit more conversation going on here. Let's find out. From time to time I will share some interesting research in #chemistry, #medicinalchemistry, #totalsynthesis and #organicchemistry.