As a rare autosomal recessive disorder, primary hyperoxaluria type 3 (PH3) presents diagnostic challenges. Read this Original Article comparing clinical characteristics of Chinese children w/PH3 and non-PH. link.springer.com/article/10.1...

The renin–angiotensin–aldosterone system is essential for BP regulation, & its absence in children w/bilateral kidney loss predisposes them to hypotension. Read this Original Article on prolonged hypotension in children w/bilateral kidney absence. link.springer.com/article/10.1...

Urinary pH influence solubility & excretion of lithogenic substances, yet its relationship w/other metabolic parameters is underexplored. Read this Original Article on impact of urine pH on lithogenic risk profile in children w/urolithiasis. Open Access link.springer.com/article/10.1...

Neonatal AKI affects approx 1/3 of newborns admitted to neonatal ICUs & is associated w/increased morbidity & mortality. Read this Review of neonatal AKI: where are we now? link.springer.com/article/10.1...

Pediatric AKI is commonly staged by pRIFLE, which uses estimated glomerular filtration rate from creatinine & cystatin C. Read this Research Letter on biomarker kinetics & early underestimation of AKI severity by pRIFLE. link.springer.com/article/10.1...

Varicella zoster (VZV) vaccination pre-kidney transplant (Tx) can help prevent severe disseminated VZV in immunosuppressed recipients. Read this Original Article on risk factors for loss of Varicella immunity after pediatric Tx. Open Access link.springer.com/article/10.1...

Pediatric nephrolithiasis is increasing globally, w/hematuria being one of its most frequent diagnostic markers. Read this Original Article on hematuria as a diagnostic marker in pediatric nephrolithiasis w/o acute obstruction or infection. link.springer.com/article/10.1...

IgA nephropathy (IgAN) is a common glomerular disease in children that may progress to CKD & kidney failure. Read this Original Article on prognosis & predictive factors in pediatric IgAN. Open Access link.springer.com/article/10.1...

Congenital lower urinary tract obstruction (cLUTO) describes a heterogeneous spectrum of congenital lower urinary tract defects w/variable postnatal outcomes. Read this Review of early diagnosis & intervention in cLUTO. Open Access link.springer.com/article/10.1...

Read this Original Article on changes in maintenance immunosuppression after pediatric kidney transplantation: a report from the Nordic pediatric kidney transplantation registry. Open Access link.springer.com/article/10.1...

CKD has unique clinical characteristics in the pediatric population, including growth disturbances & alterations in neurocognitive development. Read this Systematic Review /Meta-analysis of association between CKD & neurodevelopmental outcomes in childhood. link.springer.com/article/10.1...

There are few reports on complications of pediatric kidney biopsy, & no comparative studies between open kidney biopsy (OB) & percutaneous needle kidney biopsy in pediatric populations. Read this Original Article on safety & utility of OB in children. link.springer.com/article/10.1...

Recent studies indicate that telitacicept significantly diminishes proteinuria levels in adult patients diagnosed w/IgA nephropathy (IgAN). Read this Original Article on efficacy & safety of telitacicept in treating pediatric IgAN. link.springer.com/article/10.1...

GFR can be measured directly, or estimated from biomarkers like serum creatinine & cystatin C, or both. Measuring GFR in children is cumbersome. Read this Review of measuring & estimating GFR in children: state of the art in 2025. Free access this month. bit.ly/47meymz

Nephrotoxic medication (NTMx) exposure can cause hospital-acquired AKI in non-critically ill, hospitalized children. Read this Original Article on differences in NTMx exposure & AKI in pediatric bone marrow transplant, oncology, & pulmonary service lines. link.springer.com/article/10.1...

Autosomal dominant tubulointerstitial kidney disease (ADTKD-UMOD) typically presents w/elevated serum creatinine & gout between the 2nd & 4th decades of life. Read these Clinical Insights into UMOD-associated AKTKD-UMOD in a pediatric patient. Open Access link.springer.com/article/10.1...

Renal tubular dysgenesis is characterized by impaired development of the proximal tubules & kidney dysfunction. Read these Clinical Insights into long-term kidney function stabilization w/fludrocortisone in autosomal recessive renal tubular dysgenesis. link.springer.com/article/10.1...

Immunosuppressive drugs are required for childhood FRNS, SDNS, & SRNS. Read this Original Article on remission rates & long-term outcomes of relapsed pediatric NS: cyclophosphamide vs. cyclosporin A. link.springer.com/article/10.1...

Pediatric solid organ transplantation recipients are at increased risk of diarrhea due to immunosuppression & epidemiological risk factors. Read this Research Letter re oral immunoglobulin for norovirus diarrhea in pediatric kidney transplant recipients. link.springer.com/article/10.1...

Nephrolithiasis (NL) & nephrocalcinosis (NC) are common pediatric kidney conditions globally. Read this Original Article on genetic causes of NL & NC in a pediatric population in Saudi Arabia. Open Access link.springer.com/article/10.1...

Rituximab is a therapeutic option in children w/refractory nephrotic syndrome (RNS), but the efficacy & safety of rituximab treatment remain unclear. Read this Systematic Review /Meta-analysis of rituximab efficacy in pediatric RNS. Open Access link.springer.com/article/10.1...

Hypernatremia is a challenging condition. A rapid increase in blood sodium can draw water out of brain cells. A rapid correction to a slow increase can cause cerebral swelling. Read this Editorial Commentary on thirst, sodium & the hospitalized child. link.springer.com/article/10.1...

CKD is in WHO’s noncommunicable diseases prevention program to reduce premature mortality by 33% by 2030. There are stark regional differences in CKD burden that disproportionally affects low-income countries. Read this Editorial Commentary on CKDu in children. link.springer.com/article/10.1...

Read this Editorial Commentary on improvisation, innovation, & inequity: peritoneal dialysis in low-resource settings. link.springer.com/article/10.1...

BK virus is a polyoma virus associated w/impaired graft function in kidney transplant recipients. After primary infection, the virus becomes latent in the renal/urinary epithelium. Read these Clinical Insights into BK virus nephropathy in a native kidney. link.springer.com/article/10.1...

GFR can be measured directly, or estimated from biomarkers like serum creatinine & cystatin C, or both. Measuring GFR in children is cumbersome. Read this Review of measuring & estimating GFR in children: state of the art in 2025. Free access this month. bit.ly/47meymz

Albuminuria is a sensitive marker of early kidney injury & serves as a key indicator for the diagnosis of CKD. Read this Original Article on excessive screen time re albuminuria in adolescents: a finding from the China Nutrition and Health Surveillance. link.springer.com/article/10.1...

Read this Review of 2 of the more commonly used AI methods encountered in nephrology publications: machine vision based on convolutional neural networks (CNNs) & chatbots, such as ChatGPT, based on large language models. Open Access link.springer.com/article/10.1...

AKI is an important complication in neonates w/hypoxic ischemic encephalopathy (HIE). Read this Original Article on the association between early lactate elimination trend & AKI in neonates w/HIE receiving therapeutic hypothermia. link.springer.com/article/10.1...

Acute kidney disease (AKD) is kidney dysfunction lasting 7–90 days after AKI onset. Read this Original Article on neonatal AKD in the National Center for Child Health & Development (NCCHD)-neoAKI cohort in Japan. Topical Collection: Advances in Neonatal Nephrology. link.springer.com/article/10.1...

Energy requirements of renal proximal tubular cells depend on mitochondrial fatty acid β-oxidation. Read these Clinical Insights on long-standing low-molecular-weight proteinuria: A proximal tubular mitochondrial enzyme impairment & EHHADH mutation. link.springer.com/article/10.1...

CKD of unknown etiology (CKDu) disproportionately affects young agricultural workers in Mesoamerica & South Asia who lack traditional risk factors for kidney disease. Read this Systematic Review/ Meta-analysis of outcomes in communities impacted by CKDu. link.springer.com/article/10.1...

Advancements in pediatric cancer treatment have improved long-term survival. In childhood cancer survivors w/kidney failure, kidney transplant can be life-prolonging. Read this Educ Review of kidney disease & transplantation in childhood. Open Access. link.springer.com/article/10.1...

With the advancement of large language models (LLMs), artificial intelligence has entered society & medicine. Read this Research Letter comparing German medical guidelines w/recommendations by LLMS using the example of hemolytic uremic syndrome. link.springer.com/article/10.1...

Read Abstracts from the European Society for Paediatric Nephrology (ESPN) Congress in Athens, Greece, Oct. 13-18, 2025. link.springer.com/article/10.1...

Peritoneal dialysis (PD) sustains children w/CKD5 but promotes peritoneal membrane remodeling. Read this Original Article: Neutrophil extracellular traps drive peritoneal inflammation & tissue remodeling in pediatric PD. Open Access. link.springer.com/article/10.1...

Kidney replacement therapy (KRT) is used to treat critically ill children for many reasons, including hyperammonemia. KRT mgmt in children w/hyperammonemia not due to inborn errors of metabolism is challenging. Read this Management Dilemma for more. Open Access. link.springer.com/article/10.1...

Children on hemodialysis are vulnerable to musculoskeletal (MSK) abnormalities, which can lead to functional impairments & diminished health-related quality of life. Read this Original Article on MSK pain among children on hemodialysis. Open Access. link.springer.com/article/10.1...

Serum creatinine (SCr), a biomarker used to evaluate glomerular filtration rate (GFR), might be inaccurate in children w/sickle cell anemia (SCA). Read this Original Article on SCr- & cystatin C-based estimated GFR equations in African children w/SCA. link.springer.com/article/10.1...

Automated peritoneal dialysis consists of dwells w/the same dwell volume & time. Read this Original Article comparing double mini-peritoneal equilibration tests w/standard vs adapted dwell volumes & dwell times in children on chronic peritoneal dialysis. link.springer.com/article/10.1...

Torsemide is preferred to furosemide in adults w/heart failure for its higher bioavailability & longer half-life. Read this Original Article on efficacy & safety of torsemide vs furosemide in pediatric patients w/nephrotic syndrome. link.springer.com/article/10.1...

Few randomized controlled trials are conducted in childhood nephrotic syndrome & global practice variation exists. Read this Original Article on childhood steroid sensitive nephrotic syndrome clinical trials: results from a Delphi consensus process. link.springer.com/article/10.1...

With limited donor availability & long wait times for deceased donor transplantation, ABO-incompatible kidney transplantation (ABOiKT) offers hope to children w/kidney failure. Read this Educ Review of the history & future landscape for pediatric ABOiKT. link.springer.com/article/10.1...

Elevated serum uric acid levels are common in CKD & are associated w/cardiovascular disease. Read this Original Article on factors influencing serum uric acid levels & their impact on cardiovascular risk in patients w/pediatric CKD. link.springer.com/article/10.1...

Hyperuricemia is a common finding in kidney transplant recipients. Read these Clinical Insights into hyperuricemia & AKI associated w/use of cimetidine for treatment of mosaic warts in a pediatric kidney transplant patient. Open Access. link.springer.com/article/10.1...

Hypertension is an important risk factor in patients w/congenital anomalies of the kidney and urinary tract (CAKUT). Read this Original Article on ambulatory blood pressure in children w/CAKUT: distinctive profiles in the cystic dysplasia subgroup. link.springer.com/article/10.1...

Patients w/kidney failure require dialysis or kidney transplantation. Transplantation is often not possible due to a shortage of donor organs. Read this Review of xenotransplantation & its application to pediatric kidney disease. Free access this month. bit.ly/4nxY1BG

Pathophysiology of hypervolemia in CKD involves multiple mechanisms. Read this Original Article on the relationship between serum copeptin levels, peritoneal transport parameters & bioimpedance markers in pediatric patients undergoing peritoneal dialysis. link.springer.com/article/10.1...

CKD is relatively uncommon in children. Read this Original Article on the impact of nutritional management on growth & nutritional status of children on regular hemodialysis. Open Access. link.springer.com/article/10.1...

Although therapeutic advances have improved the life expectancy of children w/cancer, the late complication of CKD represents a challenge. Read this Original Article on incidence of & risk factors for CKD in childhood cancer survivors. link.springer.com/article/10.1...