📣 New issue online with a beautiful cover by B. Angi & F. Caicci! ➡️ www.embopress.org/toc/17574684... It highlights the study by I. Szabo & colleagues at U. of Padova "Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo" 🗞️ www.embopress.org/doi/full/10....

New paper alert!🚨CMA is selectively impaired in the RPE of AMD patients, leading to the accumulation of undegraded substrate proteins and increased vulnerability. But it can be targeted pharmacologically!💊 @cib-csic.bsky.social @dgsomucla.bsky.social

Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....

New resource online! 🐖 Benchmarking porcine #PancreaticDuctalOrganoids for #DrugScreening applications by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social 🗞️ doi.org/10.1038/s443...

#MitochondrialDamage drives #Tcell immunometabolic paralysis after major surgery By S. Hirschberger, S. Kreth, M. Hübner and colleagues at Ludwig-Maximilian-University 🗞️ doi.org/10.1038/s443...

ENOblock synergizes with colistin to treat #AcinetobacterBaumannii infections By I. Molina Panadero, Y. Smani and colleagues @pablodeolavide.upo.es 🗞️ doi.org/10.1038/s443...

A heterozygous post-zygotic ZNF334 truncation mutation in #monocytes was identified as a cause of late-onset cold-induced #AutoinflammatoryDisease ➡️ doi.org/10.1038/s443... By JL Lan, CA Yang and colleagues at China Medical University Taichung

Defective #ChaperoneMediatedAutophagy in the retinal pigment epithelium of #AgeRelatedMacularDegeneration patients By JI Jiménez-Loygorri, D. Ferrington, P. Boya & colleagues at CNIO, Friburg University & UCLA 👉 doi.org/10.1038/s443...

A 6-metabolite plasma panel was developed & validated for #GastricCancer diagnosis, revealing diagnostic potential and a mechanistic role for isovalerylcarnitine 👉 doi.org/10.1038/s443... By Yongjie Xu, Lingbin Du, Xiangdong Cheng & colleagues at Hangzhou Institute of Medicine

Don’t miss ➡️ #InSilicoModeling guides identification of novel #JAK1 variants associated with #ImmuneDysregulation By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social 🗞️ doi.org/10.1038/s443...

3D human microvessel model shows how malaria parasite Plasmodium falciparum disrupts the brain's tiny blood vessels & affects pericytes 📷 Rory K M Long et al, @embl.org Barcelona in @embomolmed.org ➡️ bpod.org.uk/archive/2025...

Online today! #CARD14 signaling in intestinal epithelial cells induces #IntestinalInflammation and intestinal transit delay By A. Aidarova, R. Beyaert, I. Afonina & colleagues @viblifesciences.bsky.social UGent ➡️ doi.org/10.1038/s443...

Proud to share our contribution with Prof. Gabbiani and Prof. De Meyer on #SMAD7 regulation in cardiac and skeletal tissue resolution, featured in @embomolmed.org (Vol. 17, No. 9 (Sep/ 2025) #CardioSky #fibrosis #muscle #vascular #inflammation

Interesting knockout phenotype on intestinal stem cell regeneration. @embomolmed.org www.embopress.org/doi/full/10....

📣 Our October issue is online! www.embopress.org/toc/17574684... This month's cover highlights the article by C. Zhu, M. Kong et al (www.embopress.org/doi/full/10....) that uncovers a new mechanism underlying #MyocardialFibrosis with druggable targets. Scientific illustration by the authors

Brown remodeling of #WhiteAdiposeTissue protects against #AbdominalAorticAneurysm via batokine FSTL1 By C. Huang, Y. Huang, B. Huang, L. Yao, J. Wang, Y. Chen, Z. Liu and colleagues at Sun Yat-Sen University ➡️ doi.org/10.1038/s443...

#AI -identified #CD133 -targeting natural compounds demonstrate differential anti-tumor effects and mechanisms in pan-cancer models By Y. Hou, Z. Wang, W. Wang, Y. Zhang, X. Dai, S. Ma & colleagues 🗞️ doi.org/10.1038/s443...

A neuroprotective tetrapeptide for treatment of #AcuteTraumaticBrainInjury By A. Mann, S. Hussain, E. Ruoslahti & colleagues @sbpdiscovery.bsky.social ➡️ doi.org/10.1038/s443...

Complete attenuation of #PlasmodiumFalciparum sporozoites by atovaquone–proguanil 👉 doi.org/10.1038/s443... By S Borrmann, Z Sulyok, K Müller, R Fendel, S Hoffman, P Kremsner, K Matuschewski, B Mordmüller & colleagues Read also related N&V by G Rochfort Peters & J Baum 👉 doi.org/10.1038/s443...

New method ➡️ Domain-substituted IGF2 tag modulates targeting of lentiviral #GeneTherapy for #HunterSyndrome By F. Catalano, WWMP Pijnappel & colleagues @erasmusmc.bsky.social 🗞️ doi.org/10.1038/s443...

📣 Metabolic #cardiomyopathies: untangling clinical heterogeneity with human #StemCell derived models By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam ➡️ doi.org/10.1038/s443...

Impaired migration and #LungInvasion of human #melanoma by a novel small molecule targeting the transmembrane domain of death receptor #p75NTR by V. Lopes-Rodrigues, C. Ibanez & colleagues doi.org/10.1038/s443...

Bead-based plasma #proteomics workflows boost proteome coverage but are vulnerable to cellular contamination, highlighting the need for contamination-aware quality control in #biomarker discovery. K. Korff, M. Mann, P. Geyer & colleagues @mpibiochem.bsky.social 🗞️ doi.org/10.1038/s443...

Glycans on non-structural protein 1 prevent premature #Tcell mediated #DengueVirus clearance By F. Idris, S. Alonso & colleagues at National Centre for Infectious Diseases Singapore 🗞️ doi.org/10.1038/s443...

Dietary supplementation of #ArachidonicAcid promotes #HumoralImmunity By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University ➡️ doi.org/10.1038/s443...

Bead-based plasma #proteomics workflows boost proteome coverage but are vulnerable to cellular contamination, highlighting the need for contamination-aware quality control in #biomarker discovery. K. Korff, M. Mann, P. Geyer & colleagues @mpibiochem.bsky.social 🗞️ doi.org/10.1038/s443...

Anti-M1R/B6R antibody characterization & bispecific design for enhanced #orthopoxvirus protection. 🗞 doi.org/10.1038/s443... by R. Zhao, L. Wu, Y. Zhang, J. Ma, J. Xue, Q. Wang & colleagues at Chinese Academy of Medical Sciences

CETN3 deficiency induces #microcephaly by disrupting neural stem/progenitor cell fate through impaired #CentrosomeAssembly and #RNAsplicing 👉 doi.org/10.1038/s443... by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University

Our September issue is online! www.embopress.org/toc/17574684... On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443... Scientific image: R. Hahn & K. Avraham, at Tel Aviv University

Identification of #p38 MAPK inhibition as a neuroprotective strategy for combinatorial #SpinalMuscularAtrophy therapy By M. Carlini, L. Pellizzoni & colleagues @columbiauniversity.bsky.social ➡️ doi.org/10.1038/s443...

Novel #Zika vaccine platform designed by disrupting viral #RNATertiaryStructure achieves tissue-specific attenuation & protection, reducing vertical transmission in animal models. X. Chen, ML Cheng, XY Huang, MX Sun, RT Li, CF Qin at Chinese Academy of Medical Sciences doi.org/10.1038/s443...

#TET3 is a regulator and can be targeted for the intervention of #MyocardialFibrosis By C. Zhu, W. Hong, Y. Zhu, D. Jiang, Y. Xu, M. Kong and colleagues at Nanjing Medical University 🗞️ doi.org/10.1038/s443...

New study by K. Avraham & colleagues ➡️ AAV #GeneTherapy rescues #hearing and #balance in a model of CLIC5 deafness 🗞️ doi.org/10.1038/s443...

EMT-ciliary signaling in quasi-mesenchymal-stem-like cells drives #TherapeuticResistance & is a druggable vulnerability in #TNBC By C Tessier, J Derrien, V Guen & al @inserm.fr @cnrs.fr 🗞️ doi.org/10.1038/s443... 👉N&V by AP Morel and @mariaouzounova.bsky.social doi.org/10.1038/s443...

Pyrin #inflammasome -driven #ErosiveArthritis caused by unprenylated RHO GTPase signaling By M. Akula, G. van Loo & colleagues at VIB Ghent 🗞️ doi.org/10.1038/s443...

🎉Congratulations to Yibing Wang at Inst Genet Dev Biol, Beijing, for winning the @embomolmed.org poster award at #OsakaMito2025!

CMG2 (alias the anthrax toxin receptor) on gut cells is vital for replenishing intestinal stem cells – insights into genetic disorder hyaline fibromatosis syndrome 📷 Lucie Bracq et al EPFL (Swiss Federal Technology Institute of Lausanne) in @embomolmed.org ➡️ bpod.org.uk/archive/2025...

🔎 Spotted in @embomolmed.org! Researchers from #KyotoUniversity, among others, used DSHB's anti-PAX7 mAb in a study on miR-33 inhibition in muscular dystrophy, revealing increased satellite cell activity and better muscle recovery. 📄 tinyurl.com/4vv6z783 🧫 dshb.biology.uiowa.edu/PAX7

Don’t miss the article by A. Caplan, F. Pasadyn and N. Mamo published in this issue of @emboreports.org ➡️ "Fool’s-gold science: The ethical and scientific perils of testing most #vaccines using placebo-controlled randomized trials" 🗞️ doi.org/10.1038/s443...

Now published in @embomolmed.org 🥳🎉 Protein-based tools for detection and characterisation of #Oropouche virus infection... See the final paper at doi.org/10.1038/s443... and read the bluetorial 👇

August issue now online! ➡️ www.embopress.org/toc/17574684... The cover highlights the study by X Qiao, J Routila, J Westermarck, S Ventelä & al @westermarcklab.bsky.social showing that LIMA1 detection can be used for #HNSCC patients stratification Scientific image by M. Peltola, Thestra Oy, Turku

A fetal oncogene NUAK2 is an emerging therapeutic target in #glioblastoma By H. Jo, S. Munoz, S. Glasgow & colleagues @ucsandiego.bsky.social 🗞️ doi.org/10.1038/s443...

Online today: Convergent activation of the #IntegratedStressResponse and ER–mitochondria uncoupling in VAPB-associated #AmyotrophicLateralSclerosis By C. Landry, H. Miranda & colleagues at Case Western Reserve University ➡️ doi.org/10.1038/s443...

Check this nice Resource by B. Hunter, J. O’Sullivan, J. Yang, S. Lal & colleagues at University of Sidney 👉 doi.org/10.1038/s443... "Left ventricular myocardial molecular profile of human diabetic #IschaemicCardiomyopathy"

📣Don’t miss this review on the current treatment framework in #ProstateCancer & novel approaches and targets that are set to transform clinical care => doi.org/10.1038/s443... by S. Nouruzi, A. Zoubeidi and colleagues at Vancouver Prostate Centre

Deadlines are approaching for @keystonesymposia.bsky.social Predicting & Responding to Emerging #Virus Infections, this October in Geneva! Our @embomolmed.org editor Zeljko Durdevic will attend. Poster abstract and registration dates => keysym.us/KSEmergingVirus26 #KSEmergingVirus26

Also online today 👉 Perspective by V. Katanaev and G. Solis at University of Geneva on #GaMutations associated with rare diseases 🗞️ doi.org/10.1038/s443...

Read this Perspective by L Martin, G Gabbiani & GRY De Meyer at University of Antwerp on the role of #SMAD7 in cardiac, skeletal muscle, and vascular tissues. 🗞️ doi.org/10.1038/s443...

De novo pyrimidine synthesis is a collateral #MetabolicVulnerability in NF2-deficient #mesothelioma 👉 doi.org/10.1038/s443... By D Xu, Y Gao, RW Peng, Y Shu et al. at University of Bern Read also N&V by J Jia & G Stathopoulos @ucy1.bsky.social @www.helmholtz-munich.de 👉 doi.org/10.1038/s443...