Hot off the press! We found that electroconvulsive therapy (ECT) induces a previously undescribed, second brain event after seizure, called cortical spreading depolarization (CSD), using optical neuroimaging in both a mouse model to human patients. 🧵 below! doi.org/10.1038/s414...

I don’t know if Charlie Kellner has a BlueSky, but if you don’t follow his ECT Blog, you should! He finds interesting articles and includes his own commentary on the value of the paper: ectpsych.blogspot.com/2025/02/use-...

Mystery Medicine Monday (best I could come up with): Propylene glycol toxicity always comes up as a concern with high dose parenteral Ativan, has anyone experienced this in clinical practice? I have given large doses of Ativan and have yet to encounter a case.

www.sciencedirect.com/science/arti... This is an important and excellent study on one of the major concerns with ECT in regards to cognitive outcomes. It sheds light on a few important points: 1) persistent depressive symptoms are deleterious to cognitive function and 2)