Heuer-Jungemann lab (@ameliehj.bsky.social)

⚠️ New Paper Alert ⚠️ We showed that penetration of DNA origami structures 🧬 into cancer spheroids depends mostly on size, BUT, their ability to fully eradicate ALL viable cells in the tumoroid, depends on the way ligands are attached 😱 Wanna know more? --> onlinelibrary.wiley.com/doi/10.1002/...

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Effects of DNA Origami‐Based Nanoagent Design on Apoptosis Induction in a Large 3D Cancer Spheroid Model The ability of DNA origami to penetrate through spheroid tissue and to induce cell death via the extrinsic apoptosis pathway is examined. Both structure of the DNA origami and the attachment of the a... https://onlinelibrary.wiley.com/doi/10.1002/smll.202502490