Researchers have discovered that butyrate, a molecule with well-documented gut benefits, fights senescence in T cells. This research suggests a potential for intervention through diet or supplementation, but further testing is required. www.lifespan.io/news/high-fi... By: Josh Conway

🧠Directly reducing the production of reactive oxygen species (ROS) at their source in astrocytes improves neuronal health and significantly increases lifespan in a mouse model of Alzheimer’s, a study suggests. www.lifespan.io/news/mice-wi... By: @arkadimazin.bsky.social

A recent review discusses the harmful effects of EDA2R, a protein that affects three inflammation-related pathways and is associated with a wide range of age-related diseases. Targeting this protein directly is challenging, but diet and exercise appear to be effective www.lifespan.io/news/eda2r-m...

Researchers identified changes in the expression of genes in eggs and their surrounding cells, which contribute to the age-related decline in female fertility.♀️ 💊Rapamycin restored balance and increased fertility rates in human trials.👶 www.lifespan.io/news/rapamyc... By: @drangowskaway.bsky.social

A new study ties the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin. Boosting their function with a growth factor offers a possible avenue for anti-aging interventions. www.lifespan.io/news/skin-ag... By: @arkadimazin.bsky.social

The October Rejuvenation Roundup is here! Catch up on news about our campaign for public longevity, new organization: Alliance for Longevity Science, Arts & Entertainment (ALSAE), interviews with leaders in the longevity field & more! Learn more: www.lifespan.io/news/rejuven...

How much exercise🏃do you need to reduce cardiovascular heart disease risk? If you are a male♂️, you need to work twice as hard as a female♀️to achieve the same benefits, a new study suggests. www.lifespan.io/news/men-mig... By: @arkadimazin.bsky.social

Researchers have found that the efficiency of autophagy, a cellular maintenance process, doesn't decline in every aging cell. In some T cells derived from healthy older people, autophagy increases rather than decreases. www.lifespan.io/news/mainten... By: Josh Conway

A recent study discovered an association between visceral and hepatic fat with cardiovascular risk factors and carotid atherosclerosis. www.lifespan.io/news/organ-f... By: @drangowskaway.bsky.social

Some chronic infections, which linger in the body and are not cleared out by the immune system, can drive cellular senescence and aging. A recent review discusses various mechanisms behind this connection. www.lifespan.io/news/review-... By: @arkadimazin.bsky.social

A study investigated the impact of mechanical forces on cellular biology. The researcher found that the extracellular matrix (ECM) stiffness encourages cells to undergo senescence. www.lifespan.io/news/stiff-c... By: Josh Conway

🧠A study suggests that an unholy duo of two proteins, amyloid and fibrinogen, causes harm in much lower concentrations than either of them alone. This observation can offer new directions for the study of Alzheimer’s. www.lifespan.io/news/amyloid... By: @arkadimazin.bsky.social

What’s the biological age of your dog? 🐕 Researchers working with data from the Dog Aging Project found that some amino acids generated from protein metabolism are more common in older dogs and can help determine the biological ages of dogs. www.lifespan.io/news/measuri... By: Josh Conway

In our recent interview, Lifespan News talked with Dr. Andrea Maier, who has been working on bringing longevity medicine to the masses. We have discussed Andreas's work and the importance of training physicians in longevity medicine. www.lifespan.io/news/andrea-... By: @arkadimazin.bsky.social

Researchers demonstrated a proof-of-concept for turning lipid injection, directly into the retina, into a possible therapy for age-related vision decline.👀 In a new study such treatment partially reversed vision decline in mice. www.lifespan.io/news/address... By: @drangowskaway.bsky.social

🧠Scientists have developed a novel multicellular integrated brain model to study neurological diseases, incorporating all six major brain cell types derived from patient-specific induced pluripotent stem cells. www.lifespan.io/news/tiny-br... @alicestanton.bsky.social By: @arkadimazin.bsky.social

What experiments conducted in space🛰️tell us about stem cells? Researchers report positive results, e.g., some organoids grow much faster under microgravity conditions than on Earth, but there are also some negative effects. You can learn more from our recent piece👇 www.lifespan.io/news/how-bei...

Scientists have found that a gene on the X chromosome, 🧬which escapes silencing, promotes inflammation 🔥 and neurodegeneration 🧠in a mouse model of multiple sclerosis, but the effects can be reversed with metformin. 💊 www.lifespan.io/news/female-... By: @arkadimazin.bsky.social

Researchers have discovered that infrared lasers promote the clearance of toxic metabolites from the aged mice's brains, improving cognition. 🧠 Similar approaches have been previously used in humans with brain damage and have had positive results. www.lifespan.io/news/infrare... By: Josh Conway

A new report from the Interventions Testing Program adds three new compounds to the list of lifespan-extending compounds confirmed during their experiments. However, these compounds extend lifespan only in male ♂️ mice.🐁 www.lifespan.io/news/interve... By: @drangowskaway.bsky.social

Scientists have found that naked mole rats, a famously long-lived species, produce a unique (and apparently improved) version of a DNA 🧬 repair protein, which is boosting their DNA repair process. www.lifespan.io/news/why-nak... By: @arkadimazin.bsky.social

A new study described core genes🧬 that appear to be causal drivers of aging, providing a list of key targets for further studies. Those genes are consistently changed over various tissues and species, and inactivating them in adulthood extends lifespan in worms. www.lifespan.io/news/researc...

Scientists have created nanoparticles that latch onto a master regulator of amyloid-beta clearance, diverting it towards a more efficient route. The treatment: 🧠drained Aβ from mouse brains and 🧠restored cognition to near wild-type levels. www.lifespan.io/news/nanopar... By: @arkadimazin.bsky.social

A group of researchers recently showcased their creation of PASS GERO, a public-facing, free application that allows researchers to evaluate potential anti-aging compounds. www.lifespan.io/news/a-publi... By: Josh Conway

Plenty of preclinical studies investigated rapamycin and showed its benefits in model organisms. However, can rapamycin extend healthspan and lifespan in healthy humans? A review of clinical studies sheds light on that question. www.lifespan.io/news/impact-... By: @drangowskaway.bsky.social

A recent study explained how partial cellular reprogramming through the OSKM factors restores nerve repair ability in older animals. www.lifespan.io/news/partial... By: Josh Conway

Matter Bioworks has a bold vision of tackling one of the hallmarks of aging -DNA damage. Lifespan News talked to Sam Sharifi, Matter Bio’s Chief Scientific Officer, about the company’s philosophy, technology, research programs, and future. www.lifespan.io/news/sam-sha... By: @arkadimazin.bsky.social

Using an AI model, Retro Biosciences was able to tweak some of the existing reprogramming factors, greatly improving reprogramming efficiency. We talked to Joe Betts-Lacroix about this announcement and other exciting Retro-related topics. www.lifespan.io/news/joe-bet... By: @arkadimazin.bsky.social

A recent study reported that the effectiveness of the senotherapeutic drug ABT-263 💊 depends on the cellular division stage at which the cell became senescent. www.lifespan.io/news/cell-cy... By: @drangowskaway.bsky.social

The September Rejuvenation Roundup is here! Catch up on rejuvenation advocacy and rejuvenation advancements news, including our new Public Longevity Group initiative and our paper on Urolithin A being accepted into Aging Cell. Learn more: www.lifespan.io/news/rejuven...

Scientists have discovered a possible mechanism behind age-related inflammation. 🔥 It involves wrong building blocks being incorporated into mitochondrial DNA🧬 during replication and can be countered by adding the correct ones. www.lifespan.io/news/faulty-... By: @arkadimazin.bsky.social

A recent study reported that an old male♂️mouse given a combination of oxytocin and a TGF-β inhibitor lived considerably longer and had improved healthspan. ❌These benefits were not seen in female♀️mice. www.lifespan.io/news/a-combi... By: Josh Conway

Scientists have reported a breakthrough in treating solid tumor cancers using a Velcro-like tool that targets glycans, surface sugars especially abundant in cancer cells. www.lifespan.io/news/new-uni... By: @arkadimazin.bsky.social

In a recent study, the researchers showed that aged cells create more reactive platelets. Since platelets are involved in blood clot formation, it suggests those platelets can be a reason for age-related increase in clotting. www.lifespan.io/news/a-poten... @brycemanso.bsky.social By: Josh Conway

Personalized medicine strategies are entering the longevity field. A recent paper discusses the results of senolytics clinical trials and how senolytics might work better in people with higher senescent cell burdens. www.lifespan.io/news/persona... By: @drangowskaway.bsky.social

Scientists have discovered a pathway behind the known effect of exercise 🏃 suppressing appetite 🥪: a lactate-related metabolite that acts directly on certain neurons.🧠 www.lifespan.io/news/exercis... By: @arkadimazin.bsky.social

Scientists have created a GPT-based model that can predict the risk of more than a thousand diseases based on the previous medical history. www.lifespan.io/news/ai-mode... @moritzgerstung.bsky.social By: @arkadimazin.bsky.social

🧠 A new study showed that elevated lipid metabolism enzyme LPCAT2 levels are associated with cognitive decline in men without the Alzheimer's-related allele APOE4. www.lifespan.io/news/lipid-m... By: Josh Conway

The Lifespan team has been busy at work this past summer, launching new initiatives and a new website, updating the Rejuvenation Roadmap, and covering stories from the longevity community and science! Check out the summary of the past few months in our editorial. 👇 www.lifespan.io/news/looking...

Public support is essential to achieve rapid progress in longevity science. Public Longevity Group is building a data-driven cultural intelligence system for longevity to track public sentiment, test narratives, and reveal which messages resonate. Learn more👇 www.lifespan.io/news/lifespa...

A recent study showed that Yamanaka factors can partially reprogram gene expression patterns related to cellular identity, leading to rejuvenation in cells and tissues, independent of inducing pluripotency. www.lifespan.io/news/partial... By: @drangowskaway.bsky.social

Even two days on a Western-like high-fat diet 🍔negatively impacts the brain 🧠and causes memory problems in mice. The good news is that returning to a normal diet restores the lost ability. www.lifespan.io/news/a-short... By: @arkadimazin.bsky.social

Not all macrophages follow the same rules! Researchers have identified and categorized several macrophage subtypes, including a subtype that appears with aging and another that manages nerve function and obesity. www.lifespan.io/news/how-mac... By: Josh Conway

🧠Scientists have demonstrated that microplastic exposure causes Alzheimer’s-like effects in APOE4 mice. These effects were sex-specific, with males♂️ experiencing apathy and females♀️ experiencing memory loss, mirroring the disease in humans www.lifespan.io/news/micropl... By: @arkadimazin.bsky.social

The researchers have published their surprising findings that epigenetic clocks 🕰️ are not significantly related to most measurements of metabolic health after weight loss interventions. www.lifespan.io/news/epigene... By: Josh Conway

An analysis of UK Biobank data showed an association between regular glucosamine 💊 use and significantly lower risks of seven non-communicable chronic diseases.📉 www.lifespan.io/news/regular... By: @drangowskaway.bsky.social

A study has found that the local brain environment is the driver of microglial aging. After being transplanted into old brains, young cells adopted aged characteristics, but their susceptibility to these signals could be turned off. www.lifespan.io/news/microgl... By: @arkadimazin.bsky.social

Scientists have found a way to directly stimulate the assembly of Complex I in mitochondria, rescuing memory deficits in mouse models of Alzheimer’s and frontotemporal dementia.🧠 www.lifespan.io/news/study-b... By: @arkadimazin.bsky.social

Scientists have found a pathway that regulates protein aggregation, a cause of several age-related neurodegenerative diseases.🧠 www.lifespan.io/news/a-mecha... @thevilchezlab.bsky.social By: @arkadimazin.bsky.social

If you could live past 100 and be healthy, would you choose to do so? The authors of a paper published in Bioethics argue against it. They make a startling case for people to die at 100 years old rather than live as long as they might choose. www.lifespan.io/news/some-bi... By: Josh Conway