💭@neerajagarwal.bsky.social shares insights on pairing targeted treatments.
In mCRPC, BRCA1/2-altered tumors show maximum benefit from PARPi monotherapy. But combo therapy (PARPi + ARPI) may extend benefit to CDK12, PALB2, ATM, though trials weren’t powered for subset analysis
#ESMO25 #MedSky
29 days ago