New research by Samuel Frey et al. evaluates post‑operative MACEs & cardiac mortality in patients following total thyroidectomy for amiodarone‑induced thyrotoxicosis, comparing pre-operative left ventricular ejection fraction impairment & risk factors. 🔗 doi.org/10.1530/ETJ-25-0292

🤖 How reliable are AI chatbots when multiple management options are clinically reasonable? A study by Grigoris Effraimidis et al. compared endocrinologists' answers to clinical scenarios with outputs from 4 conversational AI models. Read the full article #OpenAccess: doi.org/10.1530/ETJ-25-0385

A new article by Joëlle Wiersema et al. reports on a global effort involving 2 rounds of quality‑control exchange among 5 labs with extensive experience in performing deiodinase assays, with the aim of improving the comparability of assay results across labs. 🔗 doi.org/10.1530/ETJ-26-0041

New research investigates the interference frequency affecting free thyroid hormone & TSH measurements using the Roche ECLIA, along with characterizing clinical features with various interference types, emphasising the importance of recognising interference patterns. 🔗 doi.org/10.1530/ETJ-25-0396

Amiodarone‑induced thyrotoxicosis (AIT) can be difficult to manage when standard therapies fail. A new case series reports four severe refractory AIT cases where therapeutic plasma exchange aided preparation for thyroidectomy, which restored euthyroidism. 🔗 doi.org/10.1530/ETJ-25-0351 #OpenAccess

🧠 Fatigue is a disabling symptom in Graves’ disease. A new article proposes that autoimmune‑driven inflammation may disrupt astrocyte function and neuronal signalling, contributing to the profound “brain fatigue” many patients report. Read more: doi.org/10.1530/ETJ-25-0172

Daniele Ceruti et al. evaluates 2 reference cohorts of patients with sporadic MTC treated at tertiary referral centres in 2 European countries - Italy, where routine CT measurement is included in diagnostic work‑up, & the Netherlands, where it's not. 🔗 doi.org/10.1530/ETJ-25-0381

A new review highlights the significant progress that has been made in the management of thyroid eye disease, attributed to the elucidation of important pathogenic mechanisms and the development of new therapeutics validated in randomised clinical trials. doi.org/10.1530/ETJ-25-0363

An expert commentary by Leonidas H Duntas explores the findings of the GRASS trial - a randomized, double-blind, placebo-controlled, multicenter study evaluating selenium's impact on remission rates and quality of life in patients with Graves’ disease. Read the research: doi.org/10.1530/ETJ-26-0009

Jiao Wang et al. use network toxicology to predict molecular initiators involved in monoethyl phthalate-induced thyroid cancer. The full integrated analysis uncovered new insights into the potential mechanistic link between monoehyl phthalate and thyroid cancer. 🔗 doi.org/10.1530/ETJ-25-0198

Our new special collection aims to highlight the current state, future directions & challenges of de-escalation strategies in thyroid cancer management. We invite high-quality reviews & original research articles that build on this evolving field. 📧 Submit your proposal to: [email protected]

New research by Jinyoung Kim et al. evaluates the clinical applicability of an AI model, AI‑Thyroid, for thyroid nodules with atypia of undetermined significance (AUS) cytology. doi.org/10.1530/ETJ-25-0268

In a new multi‑institutional study, Sule Canberk et al. analyse 363 patients aged 0–25 years to assess the independent association between canonical somatic driver alterations and disease status at last clinical follow-up. Read the full research #OpenAccess: doi.org/10.1530/ETJ-25-0310

New research shows that EU‑TIRADS 4 nodules w back‑wall cystic figures (BWCF) have a lower malignancy risk than EU‑TIRADS 4 nodules w/out BWCF, reinforcing the importance of distinguishing BWCF from other hyperechoic foci to improve risk stratification. Read the article: doi.org/10.1530/ETJ-25-0243

How valuable is mir‑THYpe full in improving diagnosis & avoiding unnecessary thyroid surgeries? Eduarda Gregorio Arnaut Lima et al. conducts the first external, independent, real‑world validation of this microRNA classifier. Discover the results: doi.org/10.1530/ETJ-25-0105

💫 Prof. van Santen, leading paediatric endocrinologist, specialises in endocrine effects of childhood cancer & paediatric thyroid cancer. We're delighted to have her as a Collection Editor on our latest collection. ⏰There's still time to contribute: etj.bioscientifica.com/page/paediat...

How valuable is BRAF V600E as an independent prognostic marker? A new review by Garcilaso Riesco‑Eizaguirre concludes that BRAF V600E remains a cornerstone, but its optimal clinical value will be realised within a precision‑oncology framework. doi.org/10.1530/ETJ-25-0225

A new systematic review by Natasha Dowell et al. evaluates the diagnostic test accuracy of the Afirma GSC & ThyroSeq v3 molecular tests in cytologically indeterminate thyroid nodules. Read the article: doi.org/10.1530/ETJ-25-0296

💙 Uniting for thyroid health in Africa After the International Round Table - Global Challenges in Thyroid Health at the International Thyroid Congress, an editorial calls for collaboration among continental thyroid societies to strengthen clinical practice & advocacy. doi.org/10.1530/ETJ-25-0374

A new review by Bernard Rees Smith, Ricardo Núñez Miguel & Jane Sanders explores the full-length human TSH receptor (TSHR) and how monoclonal autoantibodies activate or inhibit its function. 👉 Read the article: doi.org/10.1530/ETJ-25-0261

Prof. Marek Niedziela, leading expert in paediatric thyroid diseases, is a Collection Editor for our latest Special Collection. 📢 Amplify your work - learn more: etj.bioscientifica.com/page/paediatric-thyroid-carcinoma/current-approaches-and-challenging-issues-in-paediatric-thyroid-carcinoma

A new report by Ferdy S van Geest et al. describes a novel 8‑base‑pair duplication in THRB (c.1305_1312dup; (p.R438Lfs445X)) identified in a mosaic pattern in a patient with severe thyroid hormone β (RTHβ), resulting in a distinctive developmental & thyrotoxic phenotype. doi.org/10.1530/ETJ-25-0092

🧬 Discover the emerging roles of DICER1 & DGCR8 in thyroid tumorigenesis and their impact on miRNA biogenesis and histopathologic diversity. New open-access review by Lia Rodrigues et al. synthesises the latest evidence on miRNA biogenesis & histopathologic diversity: doi.org/10.1530/ETJ-25-0188

📢 Call for Papers: Paediatric Thyroid Carcinoma – Current Approaches & Challenges Our latest special collection is led by international experts in the fields of paediatrics and endocrinology with a specialised interest in paediatric thyroid cancer. Submit: [email protected] 🔗 bit.ly/4846F5v

A new comprehensive review by Giulia Calafato et al. outlines the main somatic genetic and molecular alterations in thyroid tumors of follicular cells which drive tumour development and progression. Read the review: doi.org/10.1530/ETJ-25-0104

🌐New research by Gloria Hoi-Yee Li introduces a novel algorithm & an electronic medical database from Hong Kong to establish the first large-scale registry of thyrotoxic periodic paralysis. 🔗Read the full study #OpenAccess: doi.org/10.1530/ETJ-25-0220

🧬 Could a more systematic search for NUTM1 fusions improve the identification of poorly differentiated & anaplastic thyroid cancers? Explore the article that supports the inclusion of NUTM1 fusions in RNA sequencing panels for advanced & refractory thyroid cancers. doi.org/10.1530/ETJ-25-0100

New research by Hiroshi Katoh et al. suggests lenvatinib may help rapidly relieve airway obstruction in thyroid cancer with tracheal invasion, and could serve as a bridging therapy during genetic testing in anaplastic thyroid cancer. 📖 Full research: doi.org/10.1530/ETJ-25-0212

Latest research by Virginia Cappagli et al. assesses the prevalence of multifocality in MTC & aims to provide proof of concept that lobectomy can be safely performed. Their findings support the more conservative surgical option for certain patients with sporadic MTC. 👉 doi.org/10.1530/ETJ-25-0074

Hemithyroidectomy is chosen for low-risk DTC to preserve thyroid function, but the benefits in practice are lower than expected. Tina Toft Kristensen et al. examine outcomes for patients managed under Danish guidelines, allowing TSH up to 4 mIU/L before LT4. 👉 doi.org/10.1530/ETJ-24-0282

Trailblazing research by Eline C Jager et al. has successfully cultured organoids from medullary thyroid carcinoma biopsies, offering a novel in vitro model for physiological studies, drug discovery, tracer testing and drug screening. 📖Read the full research #OpenAccess: doi.org/10.1530/ETJ-...

📈Paediatric thyroid cancer is rising, calling for advances in clinical practice. This timely collection will explore the new WHO classification, Bethesda system alongside the challenges in evaluation & treatment. Contribute today: [email protected] 🔗 bit.ly/4gjkdMQ

Therapeutics in Graves’ disease are rapidly evolving 🚀 Marius N. Stan @mayoclinic.org & Chrysoula Dosiou @stanford.edu explore how practices have shifted over time & the direction of future patient care. 👉 Read the full review: doi.org/10.1530/ETJ-25-0078 #GravesDisease #OpenAccess

Organoid technology at the forefront of thyroid cancer research. New review by Eduardo Rios-Morris et al. @iribhm.bsky.social explores how patient- and stem-cell-derived models are transforming our understanding of complex molecular mechanisms & personalised medicine. doi.org/10.1530/ETJ-24-0392

[1/n] We've put together what I think is going to be a very good series of review articles on advanced thyroid cancer 📃 Mark this thread, I'll be posting articles as soon as they are released 📎 Published at the European Thyroid Journal 🦋 #OpenAccess etj.bioscientifica.com/page/advance...

🆕Research by Lydia B Zablotska et al. defines thyroid ultrasound volume norms for an iodine-deficient population exposed to environmental radiation. The studied Chernobyl cohort demonstrated substantial differences from MOH norms and WHO standards. Open Access: doi.org/10.1530/ETJ-25-0085

Do you want to help shape the field of #thyroidology? Join the European Thyroid Journal as a reviewer! ✅Complete 3 quality reviews in 12 months 🎉Get 25% off the APC on your next article 🔗Find out more: etj.bioscientifica.com/page/charges... 📨Any queries, please reach out: [email protected]

✨Check out the newly published expert opinion article by Aleš Ryška et al. which outlines consensus testing algorithms for differentiated, medullary and anaplastic thyroid cancer to provide standardised recommendations for treating patients with advanced #ThyroidCancer. 👉 doi.org/10.1530/ETJ-...

Could mesenchymal stem cells offer a new opportunity to improve autoimmune thyroiditis? Xun Liu et al. investigate the potential of MSCs in Hashimoto’s thyroiditis treatments. 🔗Read the full article to learn more: doi.org/10.1530/ETJ-... #Thyroid #Hashimotos

🎉Thrilled to join the @bsky.app community! We're here to share the latest research, updates and discussion on all aspects of basic, translational and clinical thyroidology. Follow us for article highlights, themed collections and developments in the field. 👉 Explore more: etj.bioscientifica.com