Reuben B. Leveson-Gower (@reubenlg.bsky.social)

Very happy to see that our latest paper just appeared online in ACS Catalysis. Two directed evolution campaigns of an artificial enzyme from @roelfesgroup.bsky.social found that just 3 mutations could specialise it towards each of its promiscuous activities. pubs.acs.org/doi/10.1021/acscatal.4c06409

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Evolutionary Specialization of a Promiscuous Designer Enzyme The evolution of a promiscuous enzyme for its various activities often results in catalytically specialized variants. This is an important natural mechanism to ensure the proper functioning of natural... https://pubs.acs.org/doi/10.1021/acscatal.4c06409

11 months ago