📣 Upcoming Webinar Nov 14! 🔬Immunity and the Liver: A trio of interesting cases 🧐 ⭐️ Drs Emily Wilson & Jingmei Lin (Wake Forest), Joshua Wong & Sadhna Dhingra (Houston Methodist), and Julia Gallardo & James Mitchell (UT Southwestern) 📨 Check your email for registration info! #pathsky #liversky

⏰Today! 🫂Our collaborative course with the European Society of Pathology at #ESPCongress - Liver biopsy in non-neoplastic liver lesions, chaired by Drs Paradis and Allende, with talks from Drs Fiel, @dinatiniakos.bsky.social , Guindi, and Zen! 🤩 ecp2025.abstractserver.com/programme/#/...

We're so excited for our May 9, 12 pm EST, Webinar Western Regional Event! What a stacked line-up up 🤩 Check your email for registration info! #liversky #pathsky

Here's Dr Szczepanski with her excellent poster! #liversky #pathsky #USCAP2025

Please join us Tuesday March 25 for our second #USCAP2025 liver poster walk!🚶‍♂️🚶‍♀️ Meet Drs Isabel Fiel and Sadhna Dhingra at poster #94 at/around 930 am 📊👥 #pathsky

Are you ready? 🥳Reception with friends PB Path & GIPS Sun March 23, 1730-1930, OMNI hotel, Marquee Room #USCAP2025 #liversky #pathsky

Dr Alkhouri leaves us with some questions: #USCAP2025 #liversky #pathsky

Collaboration is key! We're thrilled to be a Companion Society of @uscap.org ! Today at our #USCAP2025 meeting, we also joined forces with friends @aasldnews.bsky.social -Dr Naim Alkhouri -and the European Society of Pathology -Dr Christine Sempoux! 💚💛 #liversky #pathsky

Welcome to our new members inducted at our business meeting today at #USCAP2025! Want to become a member (fyi, no dues pathologists-in-training)? #liversky #pathsky hanspopperhepatopathologysociety.org/membership-a...

Thank you, Dr Joseph Misdraji, for your excellent work as Chair of our Education Committee, 2023-6!

Thank you, Dr Ilke Nalbantoglu, for your great work as Chair of our Survey Committee, 2022-5!

Thank you, Dr John Hart, for your hard work as Chair of our Membership Committee from 2022-2025!

🥉TIE - Congratulations, Dr Xing Li, who won 3rd place at our ##USCAP2025 abstract award competition! Their work on lymphoid aggregates in HCC immunotherapy response and prognosis can be seen Wed, March 26 at the am poster session (#77). #liversky #pathsky

🥉TIE - Congratulations Dr Julianne Szczepansķi, our 3rd place #USCAP2025 abstract award winner! You can see her work on HCC mimic hepatoid intrahepatic cholangiocarcinoma at the Tuesday, March 25, am poster session (#102). #liversky #pathsky

🥈Congratulations, Dr Yulin Haw, who won 2nd place in our #USCAP2025 abstract award competition! You can catch their work on HCC with RB1 aberrations at the liver platforms on Monday, March 24, room 210C, 1115-1130. #liversky #pathsky

🥇Congratulations, Dr Mengxue Zhang, our 1st place #USCAP2025 abstract award winner! You can see her work on genetic predisposition to oxaliplatin-induced SOS on Monday, March 24 in the am poster session #147 and at the liver platform, 9-915 Room 210C! #liversky #pathsky

Congratulations to our 2025 Lifetime Achievement Award recipient, Dr David Kleiner! An exceptional pathologist, researcher, mentor, leader, teacher, and friend; extremely deserving! He couldn't be with us today, so please congratulate him! 🌟 #USCAP2025 #liversky #pathsky

@ihcguy.bsky.social Some super helpful slides independent of what tissue you look at #USCAP2025 #liversky #pathsky

@ihcguy.bsky.social BAP1 loss can be helpful in well-diff biliary lesions BRAF V600E uncommon in CCA, common in BDA CD56/NCAM stains normal small ducts/ductules and can be seen in small duct CCA too Ki67 can be helpful in biliary proliferations #USCAP2025 #liversky #pathsky

Molecular alterations in liver cancers: Some can be detected by IHC (bolded) #USCAP2025 #liversky #pathsky

@ihcguy.bsky.social HCA subtyping: H&E 🗝 Then IHC...especially B-catenin, GS Remember LFABP loss can be seen in HCC #USCAP2025 #liver

@ihcguy.bsky.social Is it HCC? Remember K7 and K19 are not cholangiocarcinoma-specific! #USCAP2025 #liversky #pathsky

@ihcguy.bsky.social HCA vs HCC can be hard on biopsy! But B-catenin mutated should be treated similar to HCC per guidelines #USCAP2025 #liversky #pathsky

@ihcguy.bsky.social 🩸CD34 can help you determine if you're in a lesion (usually increased) 🕸Retic, GS, and Glypican helpful for malignant vs not (mitoses, too) 🗺Map-like GS can be hard to interpret on biopsy! #USCAP2025 #liversky #pathsky

@ihcguy.bsky.social Things to know before you do IHC in liver lesions: #USCAP2025 #liversky #pathsky

@ihcguy.bsky.social Know your stain! Remember Arginase and HSA do not stain all hepatocellular neoplasm (even well-diff) #USCAP2025 #liversky #pathsky

@ihcguy.bsky.social Reminds us that clones are important! Liver examples: B-catenin, Ki67 #USCAP2025 #liversky #pathsky

@ihcguy.bsky.social The best IHC is ... 🥁 .... H&E! 💜💗 #USCAP2025 #liversky #pathsky

@ihcguy.bsky.social is super approachable! Reach out if you have questions! 🔑 Slide! #USCAP2025 #liversky #pathsky

Dr Christine Sempoux 🥼Studies needed! 🗨Communication between pathologists and hepatologists so important! #USCAP2025 #Liversky #pathsky

Dr Christine Sempoux 🗨PSVD is a term describing a pattern with multiple causes; is not synonymous with non-cirrhotic phtn! 🔬Histologic lesions described; standard terminology suggested ❔️We don't know significance of changes in absence of phtn #USCAP2025 #Liversky #pathsky

Dr Christine Sempoux How do biopsies usually come to us? #USCAP2025 #Liversky #pathsky

Dr Christine Sempoux 🧐More studies needed! ❔️We don't know the frequency ⚠️Overdiagnosis possible (remember that portal veins are not expected in all portal tracts) #USCAP2025 #Liversky ##pathsky

Dr Christine Sempoux All 5 features should be described in biopsies: portal vein sclerosis, portal/periportal vascular changes, NRH, architectural abnormalities, sinusoidal dilation Recent Gnomes editorial: pubmed.ncbi.nlm.nih.gov/39665793/ #USCAP2025 #Liversky ##pathsky

Dr Christine Sempoux The histology can be subtle! May need to use stains and IHC to help highlight the normal structures. #USCAP2025 #Liversky ##pathsky

Dr Christine Sempoux What is recommended now for histologic terminology? pubmed.ncbi.nlm.nih.gov/30129657/ In: portal vein stenosis Out: obliterative portal venopathy 👀Trichrome and elastics can help you see #USCAP2025 #Liversky ##pathsky

Dr Christine Sempoux Histology of these vascular changes highlighted in this great paper: pubmed.ncbi.nlm.nih.gov/29644430/ #USCAP2025 #Liversky ##pathsky

Dr Christine Sempoux Clinical folks use different terms Histology varies, may or may not have portal hypertension! Confused? #USCAP2025 #Liversky ##pathsky

Dr Christine Sempoux suggests this paper on the how we got here: pubmed.ncbi.nlm.nih.gov/38881719/ #USCAP2025 #Liversky ##pathsky

Dr Christine Sempoux about to tackle a challenging topic! #USCAP2025 #Liversky ##pathsky

In the Q&A, excellent points: 💉More EUS biopsies being done, often thin, fragmented - should we recommend or standardize methods? 🤖Pathologists must be involved in AI development, training, testing! #USCAP2025 #liversky #pathsky

Dr Allende Where are we going? 💉Biopsies still important! 🤖AI and other technologies coming, but have some limitations vs pathologists #USCAP2025 #liversky #pathsky

Dr Allende Regression can be seen post-treatment Regression vs progression still being studied; ex. Type 2 pediatric pattern can mimic regression! pubmed.ncbi.nlm.nih.gov/11079009/ #USCAP2025 #Liversky ##pathsky

Dr Allende Staging difficulties: Poor trichrome stains Trichrome staining other things (retic, histiocytes) blue Thin and fragmented biopsies #USCAP2025 #liversky ##pathsky

Dr Allende 🔬Our diagnoses are still steatosis, steatohepatitis 🍸EtOH more likely if well-formed Mallory-Denk, neutrophils 🧐How much portal inflam is too much? Most have (also usually mild interface activity)! May be a marker of aggression. #USCAP2025 #liversky ##pathsky

Dr Allende 🟣Glycogenosis common, be careful not to mistake for ballooning 🧬More glycogenosis may be associated with certain genetic mutations, could be protective vs HCC and more #USCAP2025 #liversky #pathsky

Dr Allende 🪜Stage 1c - a big portal tracts not enough, pericellular periportal helpful ⚪️Microvesicular steatosis doesn't count toward total steatotic % 🔬Lipogranulomas not counted toward inflammatory foci #USCAP2025 #liversky #pathsky

Dr Allende Helpful paper on various appearances of ballooning: journals.lww.com/hepcomm/full... #USCAP2025 #liversky #pathsky

Dr Allende_ 👏🏻Gives us some history and highlights the amazing 20 year work done by the NASH CRN! 🔬Reproducility good within NASH CRN group #USCAP2025 #liversky #pathsky