Xinming Tu (@xinmingtu.bsky.social)

1/ DNA sequence models like Borzoi predict gene expression and variant effects across tissues — but how can someone adapt the model to a custom experiment? @drkbio.bsky.social, Johannes Linder and I propose a solution via parameter-efficient fine-tuning (PEFT). www.biorxiv.org/content/10.1...

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Parameter-Efficient Fine-Tuning of a Supervised Regulatory Sequence Model DNA sequence deep learning models accurately predict epigenetic and transcriptional profiles, enabling analysis of gene regulation and genetic variant effects. While large-scale training models like E... https://www.biorxiv.org/content/10.1101/2025.05.26.656171v2