As you might well imagine, the brains of those getting around 150 minutes of weekly moderate-to-vigorous exercise appeared biologically younger in MRI scans in new research. https://www.sciencealert.com/exercise-can-actually-make-your-brain-look-younger-mri-scans-reveal

Obesity and high blood pressure can directly cause dementia, not just increase the risk, according to new research. Higher body weight, particularly when it led to elevated blood pressure, actually harmed brain health. https://sciencedaily.com/releases/2026/01/260126231847.htm

Alzheimer's disease blood biomarkers rose much more quickly in obese individuals, showing obesity is a modifiable risk, according to research from our colleague Cyrus Raji. https://sciencedaily.com/releases/2025/12/251210092019.htm

The Randomized Control Trial isn’t just the most successful Alzheimer’s trial ever, it’s a building block for even more future success. Read more about what’s ahead in my new blog for Apollo Health. https://www.apollohealthco.com/archimedes-alzheimer-and-trials-a-place-to-stand/

Even after years of warnings, millions with dementia are still prescribed drugs linked to falls and confusion. Do not wait for the medical establishment to catch up to the science—take steps now to prevent and reverse cognitive decline. https://sciencedaily.com/releases/2026/01/260113220915.htm

On January 23rd at 2pm PT, Dr. Craig Tanio, one of the key trial investigators, will describe enhancements to the ReCODE protocol. To register for the webinar, click here: https://us02web.zoom.us/webinar/register/WN_-ROlIql_QtqcawMw_bIEhw#/registration

Arginine can help reduce the risk of tooth decay, shifts the oral microbiome, and reduces acid formation in the mouth. Given the mouth-brain connection, could an arginine oral rinse be neuroprotective? https://scitechdaily.com/goodbye-cavities-this-natural-amino-acid-helps-teeth-fight-sugar/

This is an important chart from our recent preprint of the Evanthea trial, which was based on ReCODE. You don’t need to accept the standard of care or settle for a reduced rate of decline - it is possible to reverse the symptoms of Alzheimer’s: https://www.apollohealthco.com/evanthea-trial/

The Evanthea randomized clinical trial has concluded, and the cognitive improvements exceed anything previously published. Join Dr. Bredesen on Friday, January 9th at 2 PM PT to discuss: https://us02web.zoom.us/webinar/register/WN_dMG3GyFlSLigtQoSanuUQA#/registration

Your body’s natural cleaning crew, mononuclear phagocytes, do less cleaning as they age. By developing “young” phagocytes using stem cells, researchers improved memory and created healthier microglia in mice. https://www.sciencealert.com/young-immune-cells-partly-reverse-alzheimers-symptoms-in-mice

Happy New Year to all, and I hope that everyone is enjoying time with loved ones. Meanwhile, we have very exciting results from our randomized controlled trial, and these have just been posted as a preprint: https://www.preprints.org/frontend/manuscript/8118568f183e2ba91ec2a1d3b3d08fb9/download_pub

Breakthroughs in medical research are addressing 4 of the world's most serious health problems: Alzheimer's, cancer, pandemics, & antibiotic resistance. Learn about advances provided by 21st-Century medicine in my new blog. https://www.apollohealthco.com/solving-four-of-the-worlds-health-problems/

Free radicals generated in non-neuronal brain cells promote dementia, according to researchers. Their study suggests that blocking this activity can protect the brain. https://news.weill.cornell.edu/news/2025/11/study-pinpoints-source-of-free-radicals-in-the-brain-that-may-fuel-dementia

A longitudinal study found that those with moderate to severe obstructive sleep apnea were far more likely to have visible cerebral microbleeds on MRIs. Identifying yet another way that sleep apnea could contribute to cognitive decline. https://www.medpagetoday.com/pulmonology/sleepdisorders/118302

Those brief bouts of attention wandering may actually be moments of brain maintenance! Attentional failures, particularly after sleep deprivation, could be the result of your brain working to remove waste. https://www.sciencealert.com/zoning-out-may-be-your-brains-rinse-cycle-study-finds

In an observational study, teens who took the antibiotic doxycycline, which is a common prescription for acne, had a reduced risk of developing schizophrenia. https://www.sciencealert.com/common-acne-medication-linked-with-30-lower-schizophrenia-risk

Tooth infections can lead to bacteria in the bloodstream, inflammation, and impaired blood sugar control. But root canals can lower blood sugar levels. https://www.theguardian.com/science/2025/nov/18/root-canal-treatment-could-significantly-lower-blood-sugar-levels-study-suggests

Neuronic is finalizing a study on light therapy. We should wait for the final results, but it's good to see improvements in sleep, quality-of-life, hand-eye coordination, recognition, & auditory perception. https://www.neuronic.online/blog/can-light-therapy-help-with-memory-what-our-study-revealed

An analysis of studies found that nitrous oxide can provide rapid improvements and also sustained benefits after repeat treatments for those with depression, especially for those who haven't responded to other treatments. https://sciencedaily.com/releases/2025/12/251202052213.htm

Clearing beta-amyloid plaques does not repair key brain functions, according to new research on the drug lecanemab. The researchers are, unfortunately, just catching up to what we’ve all known. http://sciencealert.com/one-of-our-biggest-hopes-for-alzheimers-treatment-doesnt-seem-to-work

A research team “rebalanced the activity” of a specific set of overactive neurons in the amygdala of mice and found that they reversed the symptoms of anxiety. https://www.sciencedaily.com/releases/2025/11/251104013004.htm

Walnuts, which are high in omega-3 fatty acids, polyphenols, flavonoids, and antioxidants, supported focus and memory and improved cognitive function in a new study. For max benefit, consume raw to protect the omega-3 fatty acids. https://foodandwine.com/walnuts-breakfast-brain-health-study-11840393

Frequent consumption of ultra-processed foods was associated with altered brain structure, and those differences could be part of a feedback loop promoting overeating, according to a study of 30,000 participants. https://sciencedaily.com/releases/2025/10/251020092824.htm

A new device is helping those with advanced age-related macular degeneration see again, and likely provides cognitive protection by supporting brain stimulation. https://www.nbcnews.com/health/health-news/tiny-eye-implant-special-glasses-legally-blind-patients-can-read-rcna238488

Live from Palm Springs at the California Assisted Living Association Conference! 🌴 Discussing how The Vineyards translates our research into real-life programs for their residents. Learn more about our partnership here: https://lifeatthevineyards.org/cognitive-care

Join Dr. Dale Bredesen and Judy Benjamin this Tuesday, October 28th at 3:00pm PT / 6:00pm ET as we go LIVE to talk about the final stretch of her historic walk across America. To sign up for the webinar, click here: https://us02web.zoom.us/webinar/register/WN_8GTSk8TTRnO8Obn9QN8LhQ

Flavanols, found in green tea, berries, broccoli, and other foods, have long been found to reduce cardiovascular disease risk. Now, a study shows flavanol-rich supplements reduced age-related inflammation, likely promoting cognitive health as well. https://doi.org/10.1093/ageing/afaf269

99% of heart attacks and strokes were preceded by at least one of just four risk factors. Unsurprisingly, they are all also connected with cognitive decline. https://www.sciencealert.com/huge-study-links-99-of-heart-attacks-and-strokes-with-four-risk-factors

Tiny protein clusters, called alpha-synuclein oligomers, anti-microbial proteins that may be very early triggers of Parkinson’s disease, have been directly visualized for the first time. https://www.sciencefocus.com/news/hidden-trigger-parkinsons

Three researchers won the Nobel Prize for their work on regulatory T cells (Tregs), unraveling how the immune system knows to attack foreign entities and not our own cells. https://www.cnn.com/2025/10/06/science/nobel-prize-medicine-brunkow-ramsdell-sakaguchi-immune-system-intl

Those who ate the most riboflavin (vitamin B2) cut their dementia risk in half compared to those who ate the least in a new longitudinal study. Folate (B9) and vitamin B6 also reduced risk. https://www.eatingwell.com/riboflavin-for-lower-dementia-risk-study-11824281

Increasing daytime sleepiness and worsening circadian rest-activity rhythms were associated with a higher risk of dementia. This tiredness could be a symptom of an energy imbalance, where your brain demands more than it is being supplied. https://www.neurology.org/doi/10.1212/WNL.0000000000213403

Women are more likely to develop Alzheimer’s-related dementia than men, but a new study has found that men have higher hospitalization and mortality rates than women following a dementia diagnosis, even after adjusting for age and comorbidities. https://www.medpagetoday.com/neurology/dementia/116964

A precise, personalized brain stimulation was found to ease depression rapidly, and even reduced anxiety. The connection between mental health and dementia means this research is worth following. https://newatlas.com/mental-health/hd-tdcs-brain-stimulation-precise-depression/

In a new preprint, Dr. Ram Rao found that the ReCODE protocol significantly reduced depression scores in patients with cognitive impairment. Read on to learn why ReCODE helps: https://www.apollohealthco.com/precision-medicine-protocol-shows-dual-benefits-improved-cognition-and-reduced-depression/

A recent study has found that high sugar intake can increase your risk of dementia by as much as 43%. Researchers also found that genetics can influence these numbers even further. But we already knew that, didn’t we? https://www.eatingwell.com/sugar-dementia-risk-study-11787744

We’ve highlighted the link between pollution/toxins and Alzheimer’s for years. Please take precautions, avoid polluted air when possible, use HEPA filters (or similar) in your home, and detox when air quality is low. https://jamanetwork.com/journals/jamaneurology/article-abstract/2838665

An antiparasitic used to treat pinworm can help lower the tau levels in mice. The drug targets misshapen nuclear speckles and restores their shape, reducing tau levels without causing cellular stress. https://today.ucsd.edu/story/antiparasitic-drug-shows-power-against-alzheimers-and-dementia

Join Judy Benjamin and me this Monday, September 29th at 11:00 am PT as we go LIVE to celebrate Judy’s incredible 2,000-mile milestone on her walk across America. To sign up for the webinar, click here: https://us02web.zoom.us/webinar/register/WN_UsefeGqwRTu1XnlFUw905Q#/registration

Recent research from Brazil showed those consuming the greatest amount of these sweeteners experienced a 62% faster cognitive decline. https://www.medscape.com/viewarticle/sugar-substitutes-not-so-sweet-brain-health-2025a1000nes

Can exercise prevent or help treat cancer? According to new research, yes. The study found that a single exercise session of resistance or high-intensity interval training increased anti-cancer myokines and reduced the growth of cancer cells. Wow. https://pmc.ncbi.nlm.nih.gov/articles/PMC12259798/

According to Dariush Mozaffarian, the best vegetable (or really, fruit) for heart health is the avocado. It can help lower LDL cholesterol, and provides healthy fiber, potassium, & antioxidants. https://www.realsimple.com/the-one-vegetable-for-better-heart-health-according-to-a-cardiologist-11774184

Looking for a way to put all of your dementia-fighting skills to work? Visiting new locations stimulates your brain, gets you moving, and helps keep you social, helping to keep your brain sharp. https://nypost.com/2025/08/12/health/your-summer-travel-could-be-helping-you-prevent-dementia-heres-how/

A new analysis of the efficacy of lecanemab and donanemab found a high likelihood that the antibodies had no effect for those with 2 copies of APOE4. Given the higher risk of side effects, they recommend these individuals should not receive the treatment. https://pubmed.ncbi.nlm.nih.gov/40225236/

Herpes simplex virus type 1 is becoming an established risk factor for dementia, and evidence is building that treatment with antivirals for various infections may reduce dementia risk. https://www.medscape.com/viewarticle/can-preventing-treating-herpes-reduce-dementia-risk-2025a1000kna

A heart drug slowed accumulation of phosphorylated tau protein-217 (p-Tau 217) in those with cardiovascular disease in a new trial. While the drug targets cholesterol, much of the benefit may simply come from improved cardiovascular health. https://www.medpagetoday.com/meetingcoverage/aaic/116765

A combination of epigallocatechin gallate and nicotinamide can increase clearance of amyloid beta, improve energy metabolism, and reduce oxidative stress. https://news.uci.edu/2025/08/06/uc-irvine-researchers-find-combination-of-natural-compounds-for-brain-cleaning/

A decades-long study has found that superagers can have brains similar to those of people 30 years younger. The thing they seemed to have in common was active social lives (another recommendation of our protocol). https://www.popularmechanics.com/science/health/a65632918/superagers-brains/

Surprisingly, nighttime light doesn’t just ruin your sleep - it can disrupt your body in many other ways that also increase your risk of cognitive decline and dementia. https://scitechdaily.com/the-surprising-ways-nighttime-light-wrecks-your-brain-and-body/

We’ve long documented that reducing stress has cognitive benefits, but how do you actually do it? The Independent documents four easy techniques that are worth a try. https://www.independent.co.uk/health-and-fitness/four-brain-hacks-stress-reduction-vagus-reset-b2806735.html